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two adjacent enhancers inside the first intron of the neighboring (1.4 kb downstream) ATPase gene (ATP6V0D1) modulate the human AgRP (show AGRP Proteins) promoter with profound spatiotemporal variation
Comparison of the kinetics of V-ATPase (show ATP6V1H Proteins) complexes containing Vma6p and d1 demonstrate that although the Km for ATP hydrolysis is similar, the coupling ratio is approximately 3-6-fold higher for d1-containing complexes than for Vma6p-containing complexes.
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is known as the D subunit and is found ubiquitously.
32 kDa accessory protein
, ATPase, H+ transporting, lysosomal (vacuolar proton pump), member D
, H(+)-transporting two-sector ATPase, subunit D
, V-ATPase 40 KDa accessory protein
, V-ATPase AC39 subunit
, V-ATPase subunit d 1
, V-ATPase, subunit D
, V-type proton ATPase subunit d 1
, vacuolar proton pump subunit d 1
, ATPase, H+ transporting, lysosomal, V0 subunit d1
, V-ATPase 40 kDa accessory protein
, vacuolar proton-ATPase, subunit D; V-ATPase, subunit D
, Vacuolar ATP proton pump d 1
, ATPase, H+ transporting, V0 subunit D
, ATPase, H+ transporting, lysosomal (vacuolar proton pump), 42 kDa
, ATPase, H+ transporting, lysosomal 38kDa, V0 subunit D
, lysosomal 38kDa