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As previously reported, homozygous loss of the Fth allele on a wild-type Ftl (show FTL ELISA Kits) background was embryonic lethal. expression of the H subunit can rescue the loss of the L subunit and that H ferritin homopolymers have the capacity to sequester iron in vivo
provide a new mechanism for selective autophagy of ferritin (show FTL ELISA Kits) and reveal a previously unappreciated role for autophagy and NCOA4 (show NCOA4 ELISA Kits) in the control of iron homeostasis in vivo
Our data show that ferritin H (show FTMT ELISA Kits) is required for B and T cell survival by actively reducing the labile iron pool.
Ferritin H (show FTMT ELISA Kits) deficiency in most cells of the forebrain including cells of the choroid plexus caused accumulation of cerebrospinal fluid in the lateral ventricles and the subarachnoid space
Mycobacterium avium infection induces H-ferritin expression in mouse primary macrophages by activating Toll-like receptor 2 (show TLR2 ELISA Kits).
3-Hydroxybutyrate dehydrogenase (show BDH1 ELISA Kits)-2 and ferritin-H (show FTMT ELISA Kits) synergistically regulate intracellular iron.
Fth plays a critical protective role during acute kidney injury.
FtH provides metabolic adaptation to tissue Fe overload, conferring tolerance to malaria
The delivery of iron to oligodendrocytes via H-ferritin is a biologically relevant delivery system, given that ferritin (show FTL ELISA Kits)--not transferrin (show Tf ELISA Kits)--receptors can be demonstrated on oligodendrocytes in vivo.
HFt taken up by TIM-2 positive cells transited through the endosome and eventually entered a lysosomal compartment, distinguishing the HFt pathway from that of transferrin (show Tf ELISA Kits)
Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney.
, ferritin H subunit
, ferritin heavy chain