Browse our anti-HFE2 (HFE2) Antibodies

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anti-Hemochromatosis Type 2 (Juvenile) Antibodies (HFE2)
On are 100 Hemochromatosis Type 2 (Juvenile) (HFE2) Antibodies from 17 different suppliers available. Additionally we are shipping HFE2 Kits (64) and HFE2 Proteins (14) and many more products for this protein. A total of 186 HFE2 products are currently listed.
2310035L15Rik, 5230400G09Rik, AI414844, AI789733, DKFZp468F2322, DL-M, hemojuvelin, HFE2, HFE2A, HJV, JH, Rgmc
list all antibodies Gene Name GeneID UniProt
HFE2 148738 Q6ZVN8
HFE2 310681  
HFE2 69585 Q7TQ32

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anti-Rat (Rattus) HFE2 Antibodies:

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Top referenced anti-HFE2 Antibodies

  1. Human Polyclonal HFE2 Primary Antibody for IHC (p), WB - ABIN952727 : Zhu, Feng, Li, Lu, Elston: Detecting rare variants for complex traits using family and unrelated data. in Genetic epidemiology 2010 (PubMed)
    Show all 3 references for 952727

  2. Human Polyclonal HFE2 Primary Antibody for EIA, FACS - ABIN952726 : Zhang, Yang, Wang, Tsukamoto, Enns: Hemojuvelin-neogenin interaction is required for bone morphogenic protein-4-induced hepcidin expression. in The Journal of biological chemistry 2009 (PubMed)
    Show all 3 references for 952726

  3. Human Polyclonal HFE2 Primary Antibody for ELISA, WB - ABIN566853 : Lakhal, Schödel, Townsend, Pugh, Ratcliffe, Mole: Regulation of type II transmembrane serine proteinase TMPRSS6 by hypoxia-inducible factors: new link between hypoxia signaling and iron homeostasis. in The Journal of biological chemistry 2011 (PubMed)

More Antibodies against HFE2 Interaction Partners

Human Hemochromatosis Type 2 (Juvenile) (HFE2) interaction partners

  1. A novel homozygous mutation in HJV gene identified in an Arab patient with juvenile hemochromatosis (show HFE Antibodies) and hepatocellular carcinoma.

  2. study shows that patients with CRA (show MTMR11 Antibodies) had high expression of BMP6 (show BMP6 Antibodies) and hepcidin (show HAMP Antibodies) and low expression of s-HJV. BMP6 (show BMP6 Antibodies) was found to be negatively correlated with s-HJV; both regulate hepcidin (show HAMP Antibodies) expression and play important roles in the development of anemia.

  3. HJV levels are low in NAFLD (show TSC2 Antibodies) and even lower in iron overloaded NAFLD (show TSC2 Antibodies).

  4. Data show that transmembrane serine protease (show F2 Antibodies) TMPRSS6 (show TMPRSS6 Antibodies) cleaves both the heterodimeric and the full-length mutant hemojuvelin (m-HJV).

  5. Hereditary haemochromatosis caused by homozygous HJV mutation evolved through paternal disomy.

  6. The study demonstrates that the two upstream open reading frames (with 28 and 19 codons) present in the 5' UTR (show UTS2R Antibodies) of the human HJV mRNA have the ability to significantly decrease translational efficiency under normal conditions.

  7. Case Reports: juvenile hemochromatosis (show HFE Antibodies) associated with simple heterozygosity for novel HJV mutations and unknown genetic factors.

  8. suggesting that the homozygous mutation p.C321X in HJV is causative in the patient with hemochromatosis (show HFE Antibodies)

  9. In dialysis patients, hemojuvelin levels are significantly increased but obesity does not have an additional impact.

  10. Membrane bound hemojuvelin (HJV) is associated with decreasing total kidney iron, secreting hepcidin (show HAMP Antibodies), and promoting the degradation of ferroportin (show SLC40A1 Antibodies) during acute kidney injury, whereas soluble HJV does the opposite.

Mouse (Murine) Hemochromatosis Type 2 (Juvenile) (HFE2) interaction partners

  1. Hjv (--) and Hfe (show HFE Antibodies) (C282YC282Y) transgenic mice displayed enhanced colonization of deep tissues by Yersinia pseudotuberculosis following oral inoculation, recapitulating enhanced susceptibility of humans with hemochromatosis (show HFE Antibodies) to disseminated infection with enteropathogenic Yersinia.

  2. The data demonstrate that endothelial cells are the predominant source of BMP6 (show BMP6 Antibodies) in the liver and support a model in which endothelial cells BMP6 (show BMP6 Antibodies) has paracrine actions on hepatocyte hemojuvelin to regulate hepcidin (show HAMP Antibodies) transcription and maintain systemic iron homeostasis.

  3. The minor variant of the HJV polymorphic site rs16827043 is a significant factor associated with hypertension among 50 year-old individuals compared with the AA genotype carriers. For the other polymorphic variant rs7536827, association with hypertension was found only among normal or slightly overweight A-allele carriers. In conclusion, HJV genetic variants were associated with essential hypertension in Finnish subjects.

  4. Results indicate that an efficient induction of hepcidin (show HAMP Antibodies) expression by hemojuvelin (HJV) requires its interaction with neogenin (show NEO1 Antibodies).

  5. Single Hjv(-)/(-) and double Hfe (show HFE Antibodies)(-)/(-)Hjv(-)/(-) mice exhibit comparable iron overload. Hfe (show HFE Antibodies) and Hjv regulate hepcidin (show HAMP Antibodies) via the same pathway.

  6. Results show that HFE (show HFE Antibodies) may depend on HJV for hepcidin (show HAMP Antibodies) regulation. Residual hepcidin (show HAMP Antibodies) in the absence of HFE (show HFE Antibodies) suggests either the presence of an unknown regulator synergistic with HJV or that HJV is sufficient to maintain basal levels of hepcidin (show HAMP Antibodies).

  7. Parenchymal hepatic iron overload does not suffice to trigger progression of liver steatosis to steatohepatitis or fibrosis in Hjv knockout C57BL/6 mice.

  8. Hjv is not required for sensing of body iron levels and merely functions as an enhancer for iron signaling to hepcidin (show HAMP Antibodies).

  9. Deletion of Hjv in mice leads to abnormal retinal angiogenesis/vasculogenesis, with proliferation of new, leaky blood vessels in the vitreous.

  10. Loss of matriptase-2 (show TMPRSS6 Antibodies) increases bone morphogenetic protein-dependent signaling, while paradoxically decreasing liver hemojuvelin protein content.

HFE2 Antigen Profile

Antigen Summary

The product of this gene is involved in iron metabolism. It may be a component of the signaling pathway which activates hepcidin or it may act as a modulator of hepcidin expression. It could also represent the cellular receptor for hepcidin. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Defects in this gene are the cause of hemochromatosis type 2A, also called juvenile hemochromatosis (JH). JH is an early-onset autosomal recessive disorder due to severe iron overload resulting in hypogonadotrophic hypogonadism, hepatic fibrosis or cirrhosis and cardiomyopathy, occurring typically before age of 30.

Alternative names and synonyms associated with HFE2

  • hemochromatosis type 2 (juvenile) (HFE2) antibody
  • hemochromatosis type 2 (juvenile) (Hfe2) antibody
  • hemochromatosis type 2 (juvenile) (human homolog) (Hfe2) antibody
  • hemojuvelin (LOC100355707) antibody
  • 2310035L15Rik antibody
  • 5230400G09Rik antibody
  • AI414844 antibody
  • AI789733 antibody
  • DKFZp468F2322 antibody
  • DL-M antibody
  • hemojuvelin antibody
  • HFE2 antibody
  • HFE2A antibody
  • HJV antibody
  • JH antibody
  • Rgmc antibody

Protein level used designations for HFE2

hemochromatosis type 2 (juvenile) , RGM domain family member C , haemojuvelin , hemochromatosis type 2 protein , hemojuvelin , repulsive guidance molecule c , hemochromatosis type 2 (juvenile) (human homolog) , hemochromatosis type 2 protein homolog , repulsive guidance molecule C

475830 Canis lupus familiaris
698805 Macaca mulatta
743630 Pan troglodytes
746490 Pan troglodytes
100174250 Pongo abelii
100594831 Nomascus leucogenys
148738 Homo sapiens
310681 Rattus norvegicus
100733082 Cavia porcellus
100155778 Sus scrofa
100335368 Bos taurus
101114997 Ovis aries
69585 Mus musculus
100355707 Oryctolagus cuniculus
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