Browse our MCOLN1 Proteins (MCOLN1)

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Mucolipin 1 Proteins (MCOLN1)
On www.antibodies-online.com are 3 Mucolipin 1 (MCOLN1) Proteins from 2 different suppliers available. Additionally we are shipping MCOLN1 Antibodies (48) and MCOLN1 Kits (2) and many more products for this protein. A total of 60 MCOLN1 products are currently listed.
Synonyms:
2210015I05Rik, MCOLN1, mcoln1.1, MG-2, ML4, MLIV, mln1, MST080, mucolipidin, mucolipin-1, TRP-ML1, TRPM-L1, TRPML1, zgc:63619
list all proteins Gene Name GeneID UniProt
MCOLN1 57192 Q9GZU1
MCOLN1 94178 Q99J21
Rat MCOLN1 MCOLN1 288371  

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MCOLN1 Proteins (MCOLN1) by Origin

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Zebrafish Mucolipin 1 (MCOLN1) interaction partners

  1. study characterized mcoln1.1 and mcoln1.2, the putative co-orthologs of human MCOLN1 gene

Human Mucolipin 1 (MCOLN1) interaction partners

  1. TRPML1 supports both Ca(2 (show CA2 Proteins)+) release and Ca(2 (show CA2 Proteins)+) entry.

  2. These data suggest that lysosomal adenosine accumulation impairs lysosome function by inhibiting TRPML1 and subsequently leads to cell death in B-lymphocytes.

  3. Here we identify the lipid kinase PIKfyve (show PIKFYVE Proteins) as a regulator of an alternative pathway that distributes engulfed contents in support of intracellular macromolecular synthesis during macropinocytosis, entosis, and phagocytosis. We find that PIKfyve (show PIKFYVE Proteins) regulates vacuole size in part through its downstream effector, the cationic transporter TRPML1

  4. findings suggest that TRPML1 may function as a key lysosomal Ca(2 (show CA2 Proteins)+) channel controlling both lysosome biogenesis and reformat

  5. This review summarizes the current understanding of TRPML1 activation and regulation

  6. target of rapamycin (TOR), a nutrient-sensitive protein kinase that negatively regulates autophagy, directly targets and inactivates the TRPML1 channel and thereby functional autophagy, through phosphorylation

  7. lysosomal adaptation to environmental cues such as nutrient levels requires mTOR (show FRAP1 Proteins)/TFEB (show TFEB Proteins)-dependent, lysosome-to-nucleus regulation of lysosomal ML1 channels and Ca(2 (show CA2 Proteins)+) signaling.

  8. TRPML1 has a novel role in protecting against lysosomotropic amine toxicity.

  9. Retinal pigmented epithelial cells develop a punctate phenotype within 48 hours of small interfering (si)RNA-induced TRPML1-knockdown.

  10. Data identified proteins as candidate TRPML1 interactors, and some false-positive interactors.

Cow (Bovine) Mucolipin 1 (MCOLN1) interaction partners

  1. an NAADP-sensitive Ca(2 (show CA2 Proteins)+) release channel is characteristic of TRP-ML1 channels

Mouse (Murine) Mucolipin 1 (MCOLN1) interaction partners

  1. Deletion of TRPML1 increases secretory organelle size by fusion with lysosomes. Enhanced exocytosis that was rescued by re-expression of TRPML1 in neurons.

  2. Silencing of TRPML1 hindered phagosome fusion with lysosomes.

  3. These results demonstrate that the PtdIns(3,5)P2-Mcoln1 axis has an important role in ssRNA transportation into lysosomes in DCs.

  4. ML1-null mice develop a primary, early-onset muscular dystrophy independent of neural degeneration. Dystrophin-glycoprotein complex and known membrane repair proteins are expressed normally, but membrane resealing was defective in ML1-null muscle fibers.

  5. Data identified proteins as candidate TRPML1 interactors, and some false-positive interactors.

  6. Transfection of CAMs with plasmids containing a full-length TRP-ML1 gene enhanced FasL (show FASL Proteins)-induced two-phase Ca2 (show CA2 Proteins)+ release.

  7. Loss of Trpml1 causes reduced levels and mislocalization of the gastric proton pump and alters the secretory canaliculi, causing hypochlorhydria and hypergastrinemia.

  8. This study describes, for the first time, a defect in macroautophagy in mucolipin-1-deficient mouse neurons.

  9. the loss of TRPML1 function results in intracellular chelatable zinc dyshomeostasis.

  10. TRPML1 is expressed in the mouse inner ear.

MCOLN1 Protein Profile

Protein Summary

This gene encodes a memberof the transient receptor potential (TRP) cation channel gene family. The transmembrane protein localizes to intracellular vesicular membranes including lysosomes, and functions in the late endocytic pathway and in the regulation of lysosomal exocytosis. The channel is permeable to Ca(2+), Fe(2+), Na(+), K(+), and H(+), and is modulated by changes in Ca(2+) concentration. Mutations in this gene result in mucolipidosis type IV.

Alternative names and synonyms associated with MCOLN1

  • mucolipin 1a (mcoln1a)
  • mucolipin 1 (MCOLN1)
  • mucolipin 1 (mcoln1)
  • mucolipin 1 (LOAG_04987)
  • mucolipin 1 (Mcoln1)
  • 2210015I05Rik protein
  • MCOLN1 protein
  • mcoln1.1 protein
  • MG-2 protein
  • ML4 protein
  • MLIV protein
  • mln1 protein
  • MST080 protein
  • mucolipidin protein
  • mucolipin-1 protein
  • TRP-ML1 protein
  • TRPM-L1 protein
  • TRPML1 protein
  • zgc:63619 protein

Protein level used designations for Mucolipin 1 Proteins (MCOLN1)

mucolipin 1 , mucolipin 1.1 , mucolipidin , mucolipidosis type IV protein , mucolipin-1

GENE ID SPECIES
406689 Danio rerio
426164 Gallus gallus
444113 Xenopus laevis
455656 Pan troglodytes
496811 Xenopus (Silurana) tropicalis
9942391 Loa loa
100601142 Nomascus leucogenys
57192 Homo sapiens
611517 Canis lupus familiaris
505738 Bos taurus
94178 Mus musculus
288371 Rattus norvegicus
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