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Human Monoclonal MFI2 Primary Antibody for ICFC - ABIN2664414
Dunn, Sekyere, Suryo Rahmanto, Richardson: The function of melanotransferrin: a role in melanoma cell proliferation and tumorigenesis. in Carcinogenesis 2006
Show all 4 references for 2664414
functional dissection of MTf in epithelial junction assembly and morphogenesis
Melanotransferrin is a serological marker of colorectal cancer by secretome analysis and quantitative proteomics.
PC3 (show PCSK1 Antibodies) tumors are sustained by a small number of tumor-initiating cells with stem-like characteristics, including strong self-renewal and pro-angiogenic capability and marked by the expression pattern FAM65Bhigh/MFI2low/LEF1low.
The human genome contains a second melanotransferrin gene (MTf2 (show MTF2 Antibodies)). There are two isoforms of melanotransferrin.
its ability to donate 59Fe to SK-Mel (show RAB8A Antibodies)-28 melanoma cells and other cell types
This melanoma-associated (show ZNF654 Antibodies) marker was detected in melanoma cell lines.
membrane-bound and soluble p97 (show EIF4G2 Antibodies) affect the migration capacity of endothelial and melanoma cells and suggest that p97 (show EIF4G2 Antibodies) could be involved in the regulation of plasminogen (show PLG Antibodies) activation by interacting with pro-uPA (show PRAP1 Antibodies) and plasminogen (show PLG Antibodies).
Serum melanotransferrin exists in various conformations depending on the binding of bivalent cations or following post-translational modification; serum melanotransferrin levels are unchanged in subjects with Alzheimer's disease.
The distribution of MTf and its splice variants may provide clues to their possible biological roles in melanoma and other tumors.
melanotransferrin has a role in cell proliferation and tumorigenesis
Anti-angiogenic properties of soluble melanotransferrin may result from local overstimulation of plasminogen (show PLG Antibodies) activation by tissue plasminogen activator (show PLAT Antibodies), thus leading to subsequent degradation of the fibronectin (show FN1 Antibodies) matrix and endothelial cell detachment.
MTf represents the first identification of a plant lectin receptor involved in cell-shape changes and the differentiation of animal cells
Iron indices, tissue levels, hematology, and serum chemistry parameters demonstrated no differences between metallototransferrin deficient and wild-type mice, suggesting MTf was not essential for iron metabolism.
The protein encoded by this gene is a cell-surface glycoprotein found on melanoma cells. The protein shares sequence similarity and iron-binding properties with members of the transferrin superfamily. The importance of the iron binding function has not yet been identified. This gene resides in the same region of chromosome 3 as members of the transferrin superfamily. Alternative splicing results in two transcript variants.
, melanoma-associated antigen p97
, membrane-bound transferrin-like protein
, membrane-bound transferrin-like protein p97