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Silencing of Ndfip1 inhibited cytokine-induced apoptosis of pancreatic islets and promoted glucose-stimulated insulin (show INS Proteins) secretion. These effects were associated with an increase in the cellular content of JunB (show JUNB Proteins), a potent inhibitor of ER stress and apoptosis.
Data show that membrane protein Ndfip1 recruits E3 ubiquitin (Ub) ligase Nedd4-2 to the Golgi to target ether-a-go-go-related gene (hERG) channel for degradation while membrane protein Ndfip2 also mediates Nedd4-2 interaction with hERG in the Golgi.
Ndfip1 is required during stress for ubiquitinating and trafficking BRAT1 (show C7orf27 Proteins) into the nucleus.
In Parkinson's disease, increased iron levels are associated with increased Ndfip1 expression for the regulation of DMT1 (show DMRT1 Proteins), including abnormal Ndfip1 activation in non-neuronal cell types such as astrocytes.
Ndfip1 negatively regulates RIG-I (show DDX58 Proteins)-dependent immune signaling by enhancing E3 ligase Smurf1 (show SMURF1 Proteins)-mediated MAVS (show MAVS Proteins) degradation.
Cellular up-regulation of Nedd4 family interacting protein 1 (Ndfip1) using low levels of bioactive cobalt complexes.
PTEN/Akt (show AKT1 Proteins) and MAP kinase (show MAPK1 Proteins) signaling pathways are regulated by the ubiquitin ligase activators Ndfip1 and Ndfip2 (show NDFIP2 Proteins)
Ndfip1 is required for the exosomal secretion of Nedd4 family proteins
Data show that the small PY-containing membrane proteins, NDFIP1 and NDFIP2 (NEDD4 family-interacting proteins), activate the catalytic activity of ITCH and of several other HECT ligases by binding to them.
Ndfip1 plays a critical role in regulating metal transport in human neurons through its regulation of DMT1 (show DMRT1 Proteins).
Data indicate thar Janus kinase 1 (Jak1 (show JAK1 Proteins)) degradation is dependent on Nedd4 family interacting proteins Ndfip1/Ndfip2 (show NDFIP2 Proteins).
transgene expression of Ndfip1 in the developing brain increased nuclear Pten and lengthened the cell cycle of neuronal progenitors, resulting in microencephaly.
It attenuates 6-OHDA-induced iron accumulation via regulating the degradation of DMT1 (show SLC11A2 Proteins).
The results of this study indicated that Ndfip1, through its Nedd4 effectors, is important for the development of dendrites and dendritic spines in the cortex
Ndfip1 regulates itch ligase activity and airway inflammation via UbcH7 (show UBE2L3 Proteins).
Genomic deletion of Ndfip1 abrogated nuclear trafficking of ubiquitinated Pten, even in the presence of Rab5 (show RAB5A Proteins).
Iron status and lipopolysaccharide regulate Ndfip1 by activation of nuclear factor-kappa B.
Ndfip1 deficiency precipitated autoimmune pancreatic destruction and diabetes; however, this depended on a further accumulation of nontolerant anti-self T cells from strong stimulation by exogenous tolerogen
The protein encoded by this gene belongs to a small group of evolutionarily conserved proteins with three transmembrane domains. It is a potential target for ubiquitination by the Nedd4 family of proteins. This protein is thought to be part of a family of integral Golgi membrane proteins.
Nedd4 WW binding protein 5
, Nedd4 family interacting protein 1
, Nedd4 WW domain-binding protein 5
, NEDD4 family-interacting protein 1
, breast cancer-associated protein SGA-1M
, putative MAPK-activating protein PM13
, putative NF-kappa-B-activating protein 164
, putative NFKB and MAPK-activating protein
, NEDD4 WW domain-binding protein 5
, Nedd4 WW-binding protein 5