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Human S100A9 Protein expressed in Wheat germ - ABIN1319076
Venkataraman, Cole, Svoboda, Pohl, Cole: Cationic polypeptides are required for anti-HIV-1 activity of human vaginal fluid. in Journal of immunology (Baltimore, Md. : 1950) 2005
Show all 5 Pubmed References
Human S100A9 Protein expressed in HEK-293 Cells - ABIN2731328
Yeap, Wong, Shimasaki, Teo, Quek, Yong, Diong, Bertoletti, Linn, Wong: CD16 is indispensable for antibody-dependent cellular cytotoxicity by human monocytes. in Scientific reports 2016
Data suggest that fecal calprotectin (show S100A8 Proteins) may be a potential biomarker to identify patients with ankylosing spondylitis (AS) at risk of developing inflammatory bowel disease (IBD).
S100A9 induces anti-apoptotic effect on normal and allergic neutrophils by increasing cytokine secretion of monocytes
S100A9, a protein previously described to be involved in modulation of inflammatory response, was found to interact with schistosoma MEG (show PTPN4 Proteins)-14.
Elevated S100A8 (show S100A8 Proteins) and S100A9 gene expression in SP-infected HMEECs and in the middle ear mucosa of OM, minor co-localized with neutrophil markers suggests that middle ear epithelial cell secretion of S100A8 (show S100A8 Proteins) and S100A9 may play a role in the pathogenesis of recurrent and chronic OM
The findings show that reduced PTP1B (show PTPN1 Proteins) responses contribute to disease symptoms in part by enhancing S100A9 expression during viral-associated chronic obstructive pulmonary disease exacerbations.
results of this study support an additional role of calprotectin (show S100A8 Proteins) in assessing inflammatory activity in patients with RA
High calprotectin (show S100A8 Proteins) activity could be demonstrated within the lumen of vermiform appendix specimens following appendectomy for acute appendicitis.
observations indicate a novel way in which S100A9 may contribute to the pathogenesis of gout, by priming neutrophils to respond to MSUs.
S100A9 was an ATRA-responsive gene, and PML (show PML Proteins)/RARalpha (show RARA Proteins) was necessary for the ATRA-induced expression of S100A9 in acute promyelocytic leukemia (show PML Proteins) (APL (show FASL Proteins)) cells. PML (show PML Proteins)/RARalpha (show RARA Proteins) and PU.1 were necessary for the ATRA-induced expression of S100A9 in APL (show FASL Proteins) cells. Furthermore, S100A9 promoted apoptosis in APL (show FASL Proteins) cells and affected cell growth.
Salivary S100A9 is a biomarker for oral squamous cell carcinoma in a Hungarian population.
this study shows that S100A9 inhibits B lymphopoiesis by acting on myeloid cells and promoting the release of inflammatory molecules, including IL-1beta (show IL1B Proteins)
Study verified porcine calprotectin (S100A8 (show S100A8 Proteins)/A9) expression at the protein level in multiple Haemophilus parasuis infected tissues and explored their molecular characterization.
Data suggest that up-regulation of S100A8 (show S100A8 Proteins) and S100A9 is a key component of early endometrial response to uterine involution in the post-partum period and to prevent chronic endometritis/uterine inflammation; up-regulation can be influenced by diet.
Neutrophil-derived S100A8 (show S100A8 Proteins)/A9 promotes thrombocytosis in diabetic mice
S100A9 knockdown almost completely abrogated the effects of IRF7 (show IRF7 Proteins) deletion on granulocytic myeloid-derived suppressor cells development and tumor metastasis.
Perinatal alarmins S100A8 (show S100A8 Proteins) and S100A9 specifically altered MyD88 (show MYD88 Proteins)-dependent proinflammatory gene programs. S100 programming prevented hyperinflammatory responses without impairing pathogen defense. TRIF (show RNF138 Proteins)-adaptor-dependent regulatory genes remained unaffected by perinatal S100 programming and responded strongly to lipopolysaccharide, but were barely expressed.
vitro studies on the mechanisms/pathways involved in leukemic cell differentiation revealed that binding of S100A9 to Toll-like receptor 4 (TLR4 (show TLR4 Proteins)) promotes activation of p38 mitogen-activated protein kinase (show MAPK14 Proteins), extracellular signal-regulated kinases 1 and 2, and Jun N-terminal kinase (show MAPK8 Proteins) signaling pathways, leading to myelomonocytic and monocytic AML (show RUNX1 Proteins) cell differentiation.
these results indicate that CD14 (show CD14 Proteins) is a co-receptor of TLR4 (show TLR4 Proteins) in the S100A9-induced cytokine response.
Mechanistic studies showed that in MDSCs, ATF3 (show ATF3 Proteins) was transrepressed by the GC receptor GR through direct binding to the negative GR-response element. S100A9 is the major transcriptional target of ATF3 (show ATF3 Proteins) in Granulocytic Myeloid-derived Suppressor Cells.
CHI3L1 (show CHI3L1 Proteins)-mediated cell proliferation/survival involves partial downregulation of the pro-apoptotic S100A9 protein that is highly expressed during the acute phase of colitis, by binding to the S100A9 receptor, RAGE (show AGER Proteins) (Receptor for Advanced Glycation End products).
Although MRP-8 (show S100A8 Proteins)/-14 expression is highly increased in experimental, these proteins do not contribute to the pathogenesis in the effector phase of epidermolysis bullosa acquisita and bullous pemphigoid (show DST Proteins).
Rps14 (show RPS14 Proteins) haploinsufficiency in del(5q) myelodysplastic syndrome is linked to activation of the innate immune system and induction of S100A8 (show S100A8 Proteins)-S100A9 expression, leading to a p53 (show TP53 Proteins)-dependent erythroid differentiation defect.
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of casein kinase and altered expression of this protein is associated with the disease cystic fibrosis.
S100 calcium binding protein A9
, S100 calcium-binding protein A9 (calgranulin B)
, calgranulin B
, calprotectin L1H subunit
, leukocyte L1 complex heavy chain
, migration inhibitory factor-related protein 14
, protein S100-A9
, S100 calcium binding protein A9 (calgranulin B)
, intracellular calcium-binding protein (MRP14)
, myeloid-related protein 14
, S100 calcium-binding protein A9
, RNA-binding region containing protein 2-like
, neutrophil cytosolic 23 kDa protein
, protein MRP-126