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Integrative analysis of four RNA-Seq datasets and differential expression revealed for the first time, splicing alterations of SLC39A14 and NR1I3 (show NR1I3 Proteins) in hepatocellular carcinoma.
Polymorphisms in SLC39A14 and SLC39A8 (show SLC39A8 Proteins) seemed to affect blood cadmium concentrations, for SLC39A14 this effect may occur via differential gene expression.
These results suggest that both the up-regulation of ZIP14 and the down-regulation of ZnT10 by IL-6 (show IL6 Proteins) might have enhanced the accumulation of manganese in SH-SY5Y cells.
Asparagine-linked (N-linked) glycosylation of ZIP14, particularly the glycosylation at N102, was required for efficient membrane extraction of ZIP14 and therefore is necessary for its iron sensitivity.
Zip14 expression induced by lipopolysaccharides in macrophages attenuates inflammatory response
Data show the role of ZIP14 in the hepatocyte is multi-functional since zinc and iron trafficking are altered in the Zip14(-/-) mice and their phenotype shows defects in glucose homeostasis.
the SLC39A14-exon4B transcript variant is a colorectal cancer biomarker with high sensitivity and organ-confined specificity.
Data suggest that Zip-14 mRNA level in enterocytes increases with iron or zinc depletion; Zip-14 transcript level in enterocytes decreases with zinc supplementation.
Observations indicate that ZIP14 and ZIP8 are both broad-scope metal-ion transporters that can mediate the cellular uptake of nutritionally important metals as well as the toxic heavy metal cadmium.
ZIP14 downregulation is likely involved in the depletion of zinc in the hepatoma cells in Hepatocellular cancer
the inflammation-responsive zinc transporter ZIP14 has phenotypic effects that are amplified with aging
ZIP14 is essential for manganese elimination via the gastrointestinal tract, and a lack of ZIP14 results in manganese accumulation in critical tissues such as the brain
Intravitreal holo-transferrin (show Tf Proteins) injection decreased Zip 14 protein levels. These data indicate that Zip8 (show SLC39A8 Proteins) and Zip14 may take up increasing amounts of non-transferrin (show Tf Proteins) bound iron in these two mouse models of retinal iron accumulation.
ZIP14-mediated zinc transport contributes to regulation of endosomal insulin receptor (show INSR Proteins) activity and glucose homeostasis in hepatocytes.
Results suggest that aberrant zinc distribution observed with Zip14 ablation impacts adipose cytokine production and metabolism, ultimately increasing fat deposition when exposed to endotoxin.
Slc39a14 deficiency in hemochromatotic mice greatly diminished iron loading of the liver and prevented iron deposition in hepatocytes and pancreatic acinar cells.
PrP(C (show PRNP Proteins)) promotes, and possibly regulates, the uptake of iron through DMT1 (show SLC11A2 Proteins) and Zip14 via its ferrireductase activity.
Zinc transporter ZIP14 influences aspects of the pathophysiology of nonlethal polymicrobial murine sepsis induced by cecal ligation/puncture through zinc delivery.
Oral cadmium chloride administration to ZIP14 knockout mice results in time dependent changes in gene expression.
ZIP14 is a basolaterally localized protein in enterocytes and is involved in endosomal trafficking of zinc and is necessary for proper maintenance of intestinal tight junctions
Collectively, these observations identify ZIP14 as a major contributor to NTBI uptake by beta-cells and suggest differential regulation of ZIP14 in primary human islets compared with other cell types such as hepatocytes.
Zinc is an essential cofactor for hundreds of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation. SLC39A14 belongs to a subfamily of proteins that show structural characteristics of zinc transporters (Taylor and Nicholson, 2003
LIV-1 subfamily of ZIP zinc transporter 4
, Zrt-, Irt-like protein 14
, solute carrier family 39 (metal ion transporter), member 14
, solute carrier family 39 member 14
, zinc transporter ZIP14
, zrt- and Irt-like protein 14
, Zrt- and Irt-like protein 14
, factor for adipocyte differentiation 123
, Zinc transporter ZIP14