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These findings highlight the ability of immuno-PET with (89)Zr-2109A to detect acute changes in STEAP1 expression
Data indicate that six transmembrane epithelial antigen of the prostate 1 (STEAP1) is consistently overexpressed in malignant prostate tissue, namely adenocarcinoma and prostatic intraepithelial neoplasia (PIN (show DYNLL1 Proteins)) lesions.
The findings provide evidence that STEAP1 is a biomarker of worse prognosis in prostate carcinomas patients.
STEAP1 is down-regulated by dihydrotestosterone and estradiols in LNCaP cells and in rat prostate.
STEAP1 overexpression predicts improved outcome of Ewing's sarcoma patients, possibly due to enhanced sensitivity towards ROS (show ROS1 Proteins)-generating chemotherapeutics.
EWS (show EWSR1 Proteins)-FLI1 (show FLI1 Proteins) mediated overexpression of STEAP1 increases the invasiveness and oxidative stress levels of Ewing tumor cells.
Studies suggest that activated human gammadelta T cells can efficiently present PRAME (show PRAME Proteins) and STEAP1-derived epitopes and allow breaking tolerance against these tumor-associated self-antigens.
Data suggest that zoledronic acid may affect cancer cells also by targeting the gene expression of STEAP.
Peptide STEAP-292.2L (MLAVFLPIV) may have potential as an antitumor peptide vaccine.
STEAP mRNA is used here as a marker to evaluate biological samples from individuals suspected of having cancers, and may provide prognostic information useful in defining appropriate therapeutic options.
This gene is predominantly expressed in prostate tissue, and is found to be upregulated in multiple cancer cell lines. The gene product is predicted to be a six-transmembrane protein, and was shown to be a cell surface antigen significantly expressed at cell-cell junctions.
six transmembrane epithelial antigen of the prostate 1
, metalloreductase STEAP1-like
, metalloreductase STEAP1
, six-transmembrane epithelial antigen of prostate 1
, six transmembrane endothelial antigen of PAEC