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TFR Protein expressed in - ABIN623567
Xu, Zhu, Yang, Xu, Liu, Chen: Quantitative assessment of human serum transferrin receptor in breast cancer patients pre- and post-chemotherapy using peptide immunoaffinity enrichment coupled with targeted proteomics. in Clinica chimica acta; international journal of clinical chemistry 2015
Simian immunodeficiency virus Nef-induced inhibition of TfR (show TFRC Proteins) endocytosis leads to the reduction of Transferrin (show Tf Proteins) uptake and intracellular iron concentration and is accompanied by attenuated lentiviral replication in macrophages.
Tfrc deletion dramatically suppressed both transforming growth factor-beta (TGF-beta) and bone morphogenetic protein (BMP) signaling in cranial neural crest cell-derived mandibular tissues.
decreasing TfR1 (show TFRC Proteins) expression during beta-thalassemic erythropoiesis, either directly via induced haploinsufficiency or via exogenous apotransferrin, decreases ineffective erythropoiesis and provides an endogenous mechanism to upregulate hepcidin (show HAMP Proteins), leading to sustained iron-restricted erythropoiesis and preventing systemic iron overload in beta-thalassemic mice
the value of transferrin receptors (TfRs)/cell reveals a 100-fold increase in the number of TfRs per bEnd3 cells compared to human umbilical vein cells.
our study reveals that TFR (show TFRC Proteins) functions as a novel regulator to control AMPA (show GRIA3 Proteins) trafficking efficiency and synaptic plasticity
We found that iron assimilation via Tfr1 (show TFRC Proteins) was critical for skeletal muscle metabolism, and that iron deficiency in muscle led to dramatic changes, not only in muscle, but also in adipose tissue and liver.
Mice lacking Tfr1 (show TFRC Proteins) in the heart died in the second week of life and had cardiomegaly, poor cardiac function, failure of mitochondrial respiration, and ineffective mitophagy.
Transferrin Receptor 1 Facilitates Poliovirus Permeation of Mouse Brain Capillary Endothelial Cells.
Erythrocytic iron deficiency enhances susceptibility to Plasmodium chabaudi infection in mice carrying a missense mutation in tfr1 (show TFRC Proteins).
Tfr1 (show TFRC Proteins) has a role in homeostatic maintenance of the intestinal epithelium, acting through a role that is independent of its iron-uptake function
Analysis by qPCR showed changes in mRNA levels of iron-responsive genes, indicating moderately increased iron in the RPE (show RPE Proteins) of 10-month HID mice.
This gene encodes a cell surface receptor necessary for cellular iron uptake by the process of receptor-mediated endocytosis. This receptor is required for erythropoiesis and neurologic development. Mice that are deficient in this receptor show impaired erythroid development and abnormal iron homeostasis.
transferrin receptor 1
, transferrin receptor protein 1
, mammary tumor virus receptor 1