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Browse our TMPRSS6 Proteins (TMPRSS6)

Full name:
Transmembrane Protease, serine 6 Proteins (TMPRSS6)
On are 6 Transmembrane Protease, serine 6 (TMPRSS6) Proteins from 3 different suppliers available. Additionally we are shipping TMPRSS6 Antibodies (42) and TMPRSS6 Kits (9) and many more products for this protein. A total of 60 TMPRSS6 products are currently listed.
1300008A22Rik, IRIDA
list all proteins Gene Name GeneID UniProt
Rat TMPRSS6 TMPRSS6 315388  
TMPRSS6 164656 Q8IU80
TMPRSS6 71753 Q9DBI0

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TMPRSS6 Proteins (TMPRSS6) by Origin

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More Proteins for TMPRSS6 Interaction Partners

Human Transmembrane Protease, serine 6 (TMPRSS6) interaction partners

  1. All cases were either homozygous or compound heterozygous for missense or frameshift mutations in the TMPRSS6 gene, 2 of the mutations being novel (Cys410Ser and Leu689Pro)

  2. TMPRSS6 expression is significantly downregulated in human masticatory mucosa during wound healing

  3. Matriptase-2 deficiency causes iron deficiency anemia during the early postnatal development, but not during fetal development in humans.

  4. Iron refractory iron deficiency anemia is caused by mutations of TMPRSS6 which encodes matriptase-2, a serine protease (show F2 Proteins) expressed on cell membranes of hepatocytes which is involved in the hepcidin (show HAMP Proteins) regulatory pathways by processing hemojuvelin (show HFE2 Proteins) protein.

  5. Combination of Tmprss6- ASO and the iron chelator deferiprone improves erythropoiesis and reduces iron overload in a mouse model of beta-thalassemia intermedia.

  6. Data show that p.V736A TMPRSS6 variant (rs855791) influences the susceptibility to hepatic iron accumulation in NTDT patients, and the risk allele is 736(A).

  7. A novel splicing mutation of TMPRSS6 exon 9 (c.1113G>A) was found in an iron-refractory iron deficiency anemia patient and his father.

  8. N-glycan branching regulates HAI-2 (show SPINT2 Proteins) through different subcellular distribution and subsequently access to different target proteases

  9. Data show that transmembrane serine protease (show F2 Proteins) TMPRSS6 cleaves both the heterodimeric and the full-length mutant hemojuvelin (show HFE2 Proteins) (m-HJV (show HFE2 Proteins)).

  10. genetic association studies in a population of black women in South Africa: Data suggest that SNPs in TMPRSS6 (rs228918; rs228921) are associated with iron status/iron-deficiency anemia in the population studied.

Mouse (Murine) Transmembrane Protease, serine 6 (TMPRSS6) interaction partners

  1. role of fetuin-A (show AHSG Proteins) in iron homeostasis and provide new insights into the mechanism of how matriptase-2 might modulate hepcidin (show HAMP Proteins) expression

  2. TMPRSS6 inhibition via decreased STAT5 (show STAT5A Proteins) phosphorylation may be an additional mechanism by which inflammation stimulates hepcidin (show HAMP Proteins) expression to regulate iron homeostasis and immunity.

  3. matriptase-2 (encoded by Tmprss6)-is responsible for hepcidin (show HAMP Proteins) repression throughout development, with its deficiency leading to increased hepcidin (show HAMP Proteins) levels triggering iron deficiency and anemia starting in utero

  4. The iron-regulatory serine protease (show F2 Proteins) matriptase-2 is expressed in the retina, and absence of this enzyme leads to iron deficiency.

  5. Loss of matriptase-2 increases bone morphogenetic protein-dependent signaling, while paradoxically decreasing liver hemojuvelin (show HFE2 Proteins) protein content.

  6. Results confirm the anti-inflammatory status of Tmprss6 KO mice and identify new potential target pathways/genes of Tmprss6.

  7. Tmprss6 gene knockdown reduces iron overload in an animal model of hemochromatosis (show HFE Proteins) and improves both iron overload and anemia in mice affected by beta-thalassemia.

  8. Double mutant mice lacking functional Hfe (show HFE Proteins) or Tfr2 (show TFR2 Proteins) and Tmprss6 exhibited a severe iron deficiency microcytic anemia phenotype mimicking the phenotype of single mutant mice lacking functional Tmprss6 demonstrating that Hfe (show HFE Proteins) and Tfr2 (show TFR2 Proteins) are not substrates for Tmprss6.

  9. Preventing iron overload improves beta-thalassemia and strengthens the essential role of Tmprss6 for Hamp (show HAMP Proteins) suppression, providing a proof of concept that Tmprss6 manipulation can offer a novel therapeutic option in this condition.

  10. The data do not provide support for the concept that matriptase-2 cleaves membrane hemojuvelin (show HFE2 Proteins) and may indicate that, in vivo, the role of matriptase-2 in the regulation of hepcidin (show HAMP Proteins) gene expression is more complex.

TMPRSS6 Protein Profile

Protein Summary

The protein encoded by this gene is a type II transmembrane serine proteinase that is found attached to the cell surface. The encoded protein may be involved in matrix remodeling processes in the liver.

Alternative names and synonyms associated with TMPRSS6

  • transmembrane protease, serine 6 (Tmprss6)
  • transmembrane protease, serine 6 (TMPRSS6)
  • transmembrane serine protease 6 (Tmprss6)
  • 1300008A22Rik protein
  • IRIDA protein

Protein level used designations for TMPRSS6

transmembrane protease serine 6 , transmembrane serine protease 6 , matriptase-2 , membrane-bound mosaic serine proteinase matriptase-2 , type II transmembrane serine protease 6 , matriptase 2 , transmembrane protease, serine 6

315388 Rattus norvegicus
164656 Homo sapiens
614844 Bos taurus
71753 Mus musculus
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