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anti-Human DEAF1 Antibodies:
anti-Rat (Rattus) DEAF1 Antibodies:
anti-Mouse (Murine) DEAF1 Antibodies:
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effects of loss or gain of DEAF-1 function on Drosophila development
DEAF-1 is a regulator of Drosophila immunity; it activates the expression of Mtk and Drs (show DARS Antibodies) promoter.
identified pathogenic de novo variants in two cases, a nonsense variant in IQSEC2 (show IQSEC2 Antibodies) and a missense variant in the SAND domain of DEAF1
We conclude that this DEAF1 gene alteration caused this patient's symptoms and that white matter disease should not be considered a obligate feature of this syndrome.
RAI1 (show DOM3Z Antibodies) polymorphisms rs4925102 and rs9907986 are predicted to disrupt the binding of retinoic acid RXR-RAR (show RARA Antibodies) receptors and the transcription factor DEAF1, respectively, in Smith-Magenis and Potocki-Lupski syndromes patients.
an autosomal recessive splice acceptor mutation in DEAF1 (c.997+4A>C, p.G292Pfs*) in all affected individuals, which led to exon skipping, and reduced the normal full-length mRNA copy number in the patients with epilepsy and extrapyramidal symptoms
Data show that deformed epidermal autoregulatory factor-1 (DEAF1) was located in the nucleus under the fluorescence microscope.
These data suggest that during the progression of type 1 diabetes, inflammation and hyperglycemia mediate the splicing of DEAF1 and loss of peripheral tissue antigen expression.
This study indicates, for the first time, a hereditary role of DEAF1 in white matter abnormalities, microcephaly and syndromic intellectual disability.
these results demonstrate that mutations in DEAF1 cause ID and behavioral problems, most likely as a result of impaired transcriptional regulation by DEAF1.
Pellino1 interacts with the transcription facto (show IRF3 Antibodies)r Deforme (show IRF7 Antibodies)d Epidermal Autoregulatory Factor 1 (DEAF1).
Non-genomic downregulation of 5-HT1A receptor (show HTR1A Antibodies) by 17beta-estradiol does not involve NUDR and Freud-1 (show CC2D1A Antibodies) proteins.
The sex dependence of Deaf1 function in mice is consistent with a greater role for 5-HT1A (show HTR1A Antibodies) autoreceptors in sensitivity to depression in men.
DEAF1 binds to the IFNbeta promoter and to IRF3 (show IRF3 Antibodies) and IRF7 (show IRF7 Antibodies), that it is required for the transcription of the IFNbeta gene and IFNbeta secretion
reduced DEAF1 function, and subsequent loss of Eif4g3 transcription may affect peripheral tissue antigen (PTA) expression in LNSCs and contribute to the pathology of T1D.
LMO4 (show LMO4 Antibodies) modulates the activity of the DEAF NES (show NES Antibodies), causing nuclear accumulation of a construct containing the LMO4 (show LMO4 Antibodies)-interaction region of DEAF1.
Reduced raphe 5-HT (show DDC Antibodies) content in Deaf-1(-/-) mice indicate its importance in regulation of 5-HT1A (show HTR1A Antibodies) gene expression and the role of the 5-HT1A (show HTR1A Antibodies) G(-1019) allele in reducing serotonergic neurotransmission by derepression of 5-HT1A (show HTR1A Antibodies) autoreceptors.
These results suggest that transcription factors such as Aire and Deaf1, which exert global transcriptional regulatory functions, may play important roles in self-renewal of ESCs and maintaining ESC in a transcriptionally hyperactive state.
Data indicate an important role for LMO4 (show LMO4 Antibodies) and Deaf-1 in pathways affecting neural tube closure and skeletal patterning, most likely reflecting their presence in a functional complex in vivo.
Lower peripheral tissue antigens (PTA (show PTCRA Antibodies)) expression resulting from the alternative splicing of DEAF1 may contribute to the pathogenesis of type 1 diabetes.
Transcription factor that binds the homeotic Deformed (Dfd) response element. High affinity binding sites contain at least 1 TTCG motif surrounded by additional TCG sequences. May be involved in the selective action of Dfd on these sites without binding directly to the Dfd protein. Requirement of DEAF1 activity may be a common feature of enhancers targeted by Dfd.
, deformed epidermal autoregulatory factor-1
, deformed epidermal autoregulatory factor 1 homolog
, deformed epidermal autoregulatory factor 1 (Drosophila)
, deformed epidermal autoregulatory factor 1 homolog-like
, deformed epidermal autoregulatory factor 1
, nuclear DEAF-1-related transcriptional regulator
, zinc finger MYND domain-containing protein 5
, DEAF-1 related transcriptional regulator (NUDR)
, DEAF-1 related transcriptional regulator
, nuclear DEAF-1 related transcriptional regulator
, zinc finger MYND domain containing 5