Browse our DVL2 Proteins (DVL2)

Full name:
Dishevelled, Dsh Homolog 2 Proteins (DVL2)
On are 2 Dishevelled, Dsh Homolog 2 (DVL2) Proteins from 2 different suppliers available. Additionally we are shipping DVL2 Antibodies (3) and many more products for this protein. A total of 6 DVL2 products are currently listed.
list all proteins Gene Name GeneID UniProt
DVL2 1856 O14641

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Human Dishevelled, Dsh Homolog 2 (DVL2) interaction partners

  1. Our findings reveal an underappreciated role of Dvl2 in regulating inflammation and rheumatoid arthritis-fibroblast-like synoviocyte apoptosis

  2. two mutually exclusive functions of the DEP domain in Wnt (show WNT2 Proteins) signal transduction - binding to Frizzled to recruit Dishevelled to the receptor complex, is reported.

  3. inhibition of DVL2 can sensitize cisplatin-resistant lung cancer cells through down-regulating Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling.

  4. Data show that RAP1B (show RAP1B Proteins) expression was up-regulated in esophageal squamous cell carcinoma (ESCC) clinical samples and RAP1B (show RAP1B Proteins) interacted with DVL2 and activated Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling.

  5. ESCC patients with high Dvl2 expression had worse prognoses and multivariate analysis indicated that Dvl2 was an independent risk factor for ESCC patients' survival. Our clinical data indicated that Dvl2 contribute to the malignant progression of ESCC and might be a prognostic biomarker.

  6. Data show that dishevelled proteins DVL1 (show DVL1 Proteins), 2 and 3 were exclusively expressed in chronic lymphatic leukaemia (CLL) cells as compared to normal peripheral blood mononuclear cells (PBMCs).

  7. The secreted frizzled-related protein (show SFRP2 Proteins) and disheveled protein family members appear to be actively involved in the pathogenesis of primary testicular germ cell tumors.

  8. In pancreatic cancer cells, AF6 is expressed at reduced levels, causing Dvl2 to be upregulated and available to bind and enhance FOXE1 (show FOXE1 Proteins)-induced trans-activation of Snail (show SNAI1 Proteins), which promotes proliferation and metastasis.

  9. Epsins are required for Dishevelled stability and Wnt (show WNT2 Proteins) signalling activation in colon cancer development.

  10. The data suggest that the expression of DVL2 in colon tissue segments may be important in the pathogenesis of HSCR (show EDNRB Proteins).

DVL2 Protein Profile

Protein Summary

This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans.

Alternative names and synonyms associated with DVL2

  • dishevelled segment polarity protein 2 (DVL2)

Protein level used designations for DVL2

dishevelled 2 (homologous to Drosophila dsh) , dishevelled, dsh homolog 2 , segment polarity protein dishevelled homolog DVL-2

1856 Homo sapiens
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