Browse our GRHL2 Proteins (GRHL2)

Full name:
Grainyhead-Like 2 (Drosophila) Proteins (GRHL2)
On are 5 Grainyhead-Like 2 (Drosophila) (GRHL2) Proteins from 3 different suppliers available. Additionally we are shipping GRHL2 Antibodies (37) and many more products for this protein. A total of 47 GRHL2 products are currently listed.
0610015A08Rik, BOM, DFNA28, grhl2, RGD1561191, si:dkey-21k18.2, Tcfcp2l3, TFCP2L3
list all proteins Gene Name GeneID UniProt
GRHL2 79977 Q6ISB3
GRHL2 252973 Q8K5C0
Rat GRHL2 GRHL2 299979  

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GRHL2 Proteins (GRHL2) by Origin

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More Proteins for GRHL2 Interaction Partners

Human Grainyhead-Like 2 (Drosophila) (GRHL2) interaction partners

  1. GRHL2 maintained AR expression in multiple prostate cancer model systems, was required for cell proliferation, enhanced AR's transcriptional activity, and colocated with AR at specific sites on chromatin to regulate genes relevant to disease progression.

  2. Studies indicate that Grainyhead-like transcription factor 2 (show HNF1B Proteins) (GRHL2) controls the expression of E-cadherin (CDH1 (show CDH1 Proteins)) required for adherens junctions and possibly regulates the expression of claudin-4 (CLDN4 (show CLDN4 Proteins)) in tight junctions.

  3. results indicated GRHL2 might be a noise-induced hearing loss (NIHL) susceptibility gene, but the effect of POU4F3 (show POU4F3 Proteins) on NIHL could only be detected when taking noise exposure into account and their effects were enhanced by higher levels of noise exposure

  4. These data are indicative for a strong oncogenic potential of the GRHL2 gene in epithelial ovarian cancer cells displaying either epithelial (A2780s) or mesenchymal (SKOV3) phenotypes.

  5. marked overlap of dyskeratosis congenita with four other genetic syndromes, confounding accurate diagnosis and subsequent management. Patients with clinical features of dyskeratosis congenita need to have genetic analysis of USB1 (show USB1 Proteins), LIG4 (show LIG4 Proteins) and GRHL2 in addition to the classical dyskeratosis congenita genes and telomere length measurements.

  6. In this review, we summarized recent progress on grainyhead-like 2 in development and cancer in order to get an insight into the regulation network of grainyhead-like 2 and understand the roles of grainyhead-like 2 in various cancers.

  7. A loss or strong reduction in GRHL2 expression appears to be a characteristic of cervical cancer, suggesting that GRHL2 down-regulation is a necessary step during cervical carcinogenesis.

  8. In skin from psoriasis patients, the effect of miR (show MLXIP Proteins)-194 on cell proliferation and differentiation was significantly reversed by overexpression of GRHL2. Moreover, the expression of miR (show MLXIP Proteins)-194 and GRHL2 was inversely correlated in psoriasis lesional skin. Taken together, our results suggest that miR (show MLXIP Proteins)-194 inhibits the proliferation and promotes the differentiation of keratinocytes through targeting GRHL2.

  9. A novel connection between GRHL2 and miR (show MLXIP Proteins)-200 in oral cancer.Grainyhead-like 2 regulates epithelial plasticity and stemness in oral cancer cells.

  10. GRHL2 genetic polymorphisms, rs611419 and rs10955255, have a protective role against sudden sensorineural hearing loss (SSHL) and reduce the risk of SSHL. However, rs6989650 is not associated with SSHL.

Mouse (Murine) Grainyhead-Like 2 (Drosophila) (GRHL2) interaction partners

  1. GRHL2 promotes the epithelial nature of non-neural ectoderm during dynamic events of neural tube formation by both activating key epithelial genes and actively suppressing epithelial-mesenchymal (EMT (show ITK Proteins)) transition through novel downstream EMT (show ITK Proteins) suppressors.

  2. a Grhl2/Ovol2 (show OVOL2 Proteins) network controls Cldn4 (show CLDN4 Proteins) and Rab25 (show RAB25 Proteins) expression that facilitates lumen expansion and barrier formation in subtypes of renal epithelia

  3. Our findings reveal important pathophysiological differences between human pulmonary fibrosis and specific mouse models of fibrosis and support a crucial role of GRHL2 in epithelial activation in lung fibrosis and perhaps also in epithelial plasticity.

  4. expression of GRHL2 is directly suppressed by the ZEB1, which in turn is a direct target for repression by GRHL2, suggesting that the EMT transcription factors GRHL2 and ZEB1 form a double negative regulatory feedback loop

  5. Grhl2 plays an essential role in the determination of epithelial phenotype of breast cancers, EMT (show ITK Proteins) and tumor progression

  6. the results indicate that Grhl2 regulates epithelial morphogenesis through transcriptional up-regulation of Cldn3 (show CLDN3 Proteins) and Cldn4 (show CLDN4 Proteins), as well as of Rab25 (show RAB25 Proteins), which increases the Cldn4 (show CLDN4 Proteins) protein and its localization at TJs

  7. Grhl2 and Nkx2-1 (show NKX2-1 Proteins) bind to each other's promoter in vivo, forming a positive feedback regulatory loop.

  8. Over-expression of Grhl2 causes spina bifida in the Axial defects mutant mouse

  9. tissue closure defects in Grhl2 mutants are similar to that of AP-2alpha (show TFAP2A Proteins) null mutants and AP-2alpha (show TFAP2A Proteins) has been shown to bind to the promoter of E-cadherin (show CDH1 Proteins)

  10. Both GRHL2 and GRHL3 (show GRHL3 Proteins) bind to and regulate expression of the wound repair gene Rho GEF (show ARHGEF2 Proteins) 19, but regulation of the barrier forming gene, Transglutaminase 1 (TGase1 (show TGM1 Proteins)), is unique to GRHL3 (show GRHL3 Proteins).

Zebrafish Grainyhead-Like 2 (Drosophila) (GRHL2) interaction partners

  1. The data showed that midbrain-hindbrain boundary maintenance and morphogenesis are dissociable events regulated by grhl2b through diverse transcriptional targets.

  2. This work reveals an evolutionarily conserved function of Grhl2 in otic development and provides a fish model for further studying mechanisms of Grhl2-related hearing loss.

GRHL2 Protein Profile

Protein Summary

The protein encoded by this gene is a transcription factor that can act as a homodimer or as a heterodimer with either GRHL1 or GRHL3. Defects in this gene are a cause of non-syndromic sensorineural deafness autosomal dominant type 28 (DFNA28).

Alternative names and synonyms associated with GRHL2

  • grainyhead-like 2 (Drosophila) (GRHL2)
  • grainyhead-like 2 (Drosophila) (Grhl2)
  • grainyhead-like 2b (Drosophila) (grhl2b)
  • 0610015A08Rik protein
  • BOM protein
  • DFNA28 protein
  • grhl2 protein
  • RGD1561191 protein
  • si:dkey-21k18.2 protein
  • Tcfcp2l3 protein
  • TFCP2L3 protein

Protein level used designations for GRHL2

grainyhead-like 2 (Drosophila) , transcription factor CP2-like 3 , brother of mammalian grainyhead , grainyhead-like protein 2 homolog , grainyhead like 2 , grainyhead-like 2 , grainyhead-like 2b protein

464320 Pan troglodytes
706549 Macaca mulatta
100056140 Equus caballus
429506 Gallus gallus
79977 Homo sapiens
481985 Canis lupus familiaris
519918 Bos taurus
252973 Mus musculus
299979 Rattus norvegicus
100034503 Danio rerio
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