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These findings indicate that HAND2 loss-of-function mutation contributes to human CHD (show CHDH Proteins), perhaps via its interaction with GATA4 (show GATA4 Proteins) and NKX2.5 (show NKX2-5 Proteins).
HAND2 and microRNA-1 facilitated the early progress of human induced cardiomyocyte-like cells reprogramming.
this study is the first to report the association of a HAND2 loss-of-function mutation with an increased vulnerability to tetralogy of Fallot in humans, which provides novel insight into the molecular mechanism underpinning congenital heart disease
HAND2-mediated proteolysis negatively regulates the function of estrogen receptor alpha (show ESR1 Proteins).
suggest that HAND2 plays a key role in the regulation of progestin-induced decidualization of human endometrial stromal cells.
Reduced protein expression of HAND2 in the myenteric plexus of the aganglionic segment would suggest that HAND2 was involved in the pathogenesis of Hirschsprung disease.
Increased HAND2 methylation was a feature of premalignant endometrial lesions and was seen to parallel a decrease in RNA and protein levels.
Overdosage of Hand2 causes limb and heart defects in the human chromosomal disorder partial trisomy distal 4q.
No evidence of linkage between HAND2 and CL/P was obtained. Levelss of exclusion were obtained with different inheritance models. results did not support HAND2 in CL/P
Expression analyses on both Hand2 conditionally null and hypomorphic backgrounds demonstrate that Hand2 is required for reporter activation in a gene dosage-dependent manner during sympathetic neurogenesis.
Ptn (show PTN Proteins) may play a vital role in the progesterone-induced decidualization pathway via C/EBPB (show CEBPB Proteins)-cyclic AMP (show TMPRSS5 Proteins)-Hand2 signaling.
Results demonstrate a change in Hand2 target genes during maturation of sympathetic neurons. Whereas Hand2 controls genes regulating noradrenergic differentiation during development, Hand2 seems to be involved in the regulation of genes controlling neurotransmission in adult sympathetic neurons.
Surviving Hand1 (show HAND1 Proteins);Hand2 mutants display diminished cardiac function that is rescued by concurrent ablation of Hand-null cardiomyocytes. Collectively, we conclude that, within a mixed cardiomyocyte population, removal of defective myocardium and replacement with healthy endogenous cardiomyocytes may provide an effective strategy for cardiac repair.
This study showed that Gja1 (show GJA1 Proteins) may act downstream of cAMP-PKA signal to mediate the effects of Acvr1 (show ACRV1 Proteins) on the differentiation of uterine stromal cells through targeting Hand2.
transcription of a Hand2-associated long non-coding RNA, which we named upperhand (Uph), is required to maintain the super-enhancer signature and elongation of RNA polymerase II through the Hand2 enhancer locus
endocardial Hand2 is an integral downstream component of a Notch (show NOTCH1 Proteins) endocardium-to-myocardium signaling pathway and a direct transcriptional regulator of Neuregulin1.
analysis uncovers the transcriptional circuits that function in establishing distinct mesenchymal compartments downstream of HAND2 and upstream of SHH (show SHH Proteins) signaling
Suggest that prenatal alcohol exposure causes the over-expression of DHAND and EHAND (show HAND1 Proteins) by increasing H3K14ac in the fetal heart.
Hand2 loss-of-function dramatically reduces expression of Dopamine Beta Hydroxylase (Dbh (show DBH Proteins)), a gene encoding a crucial catecholaminergic biosynthetic enzyme
in vivo inhibition of miR (show MLXIP Proteins)-25 by a specific antagomir evoked spontaneous cardiac dysfunction and sensitized the murine myocardium to heart failure in a Hand2-dependent manner
hand2 and the co-expressed zinc-finger transcription factor osr1 (show OSR1 Proteins) have functionally antagonistic influences on kidney development. Together, our data suggest that hand2 functions in opposition to osr1 (show OSR1 Proteins) to balance the formation of kidney and vein progenitors by regulating cell fate decisions at the lateral boundary of the Iintermediate mesoderm
hand2 can drive cardiomyocyte production in multiple contexts and through multiple mechanisms
These findings point to complexity of regulation by edn1 and hand2 at the earliest stages of pharyngeal arch development, in which control of growth and morphogenesis can be genetically separated.
Data indicate that mouse and zebrafish hand2 enhancers both drive transgene expression in the pharyngeal arches.
reduction of fn1 (show FN1 Proteins) function enables rescue of cardiac fusion in hand2 mutants
the expression and function of hand2 and dlx3b/4b/5a genes specify major patterning domains along the dorsoventral axis of zebrafish pharyngeal arches
Our study reveals an unexpected role for Hand2, a key regulator of cell specification and differentiation, in modulating ECM (show MMRN1 Proteins) remodeling during organogenesis
Hand2-endothelin 1 (show EDN1 Proteins) effector, patterns ventral pharyngeal cartilage
Hand2 is uniquely required for myocardial polarization.
These results demonstrate in vivo an essential and selective function of hand2 for the noradrenergic differentiation of sympathetic neurons, and implicates tfap2a (show TFAP2A Proteins) and gata2 as downstream effectors.
The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, this transcription factor plays an important role in limb and branchial arch development.
basic helix-loop-helix transcription factor HAND2
, class A basic helix-loop-helix protein 26
, deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2
, heart- and neural crest derivatives-expressed protein 2
, dHand protein
, heart and neural crest derivatives expressed transcript 2
, heart and neural crest derivatives expressed 2
, helix-loop-helix transcription factor expressed in embryo and deciduum
, hands off
, dHAND basic helix-loop-helix transcription factor