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IRX2 transcription factor might represent a novel metastasis associated protein that acts as a negative regulator of cellular motility and as a repressor of chemokine (show CCL1 ELISA Kits) expression and loss of IRX2 expression could therefore contribute to early hematogenous dissemination of breast cancer by sustaining chemokine (show CCL1 ELISA Kits) secretion and enabling mobilization of tumor cells.
IRX2 modulates the expression levels of MMP2 and VEGF in an AKTdependent manner.
The mechanism by which IRX2 promoted cell proliferation and invasion by activating AKT (show AKT1 ELISA Kits) and MMP9 (show MMP9 ELISA Kits) was detected.
Results revealed 3 genes highly predictive of event-free survival (EFS (show EFS ELISA Kits)), beyond age and MLL (show MLL ELISA Kits) status: FLT3 (show FLT3 ELISA Kits), IRX2, and TACC2 (show TACC2 ELISA Kits).
IRX2 represents a candidate target of 5p amplifications in soft tissue sarcomas and might play a crucial role during the progression of this disease.
generation and phenotypic analysis of an Irx2-deficient mouse strain. Irx2-deficient mice are viable, are fertile, and appear to be normal.
This homeobox protein (show HOXA1 ELISA Kits) is expressed during early lung development.
This homeobox protein (show HOXA1 ELISA Kits) is expressed during digit development.
IRX2 is a member of the Iroquois homeobox gene family. Members of this family appear to play multiple roles during pattern formation of vertebrate embryos.
homeodomain protein IRXA2
, iroquois homeobox protein 2
, iroquois-class homeodomain protein IRX-2
, Iroquois related homeobox 2
, Iroquois related homeobox 5
, iroquois-class homeobox protein Irx6