Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Show all synonyms
the association between FTO and obesity appears to be due to its influence on expression of IRX3 [Figure 1]. Genetic studies indicated FTO as an important gene for obesity risk in various populations but the recent developments suggest that obesity-associated FTO SNPs have long-range interactions with IRX3.
Downregulation of miR (show MLXIP ELISA Kits)-377 may contribute to the upregulation of IRX3 in HCC (show FAM126A ELISA Kits).
This is the first study to reveal that genetic variants of both FTO and IRX3 genes are in high linkage disequilibrium (LD) and are associated with obesity risk in North Indians.
Strategies to pharmacologically regulate Irx3 function in adult endothelial cells may provide new therapies for angiogenesis.
data suggest that IRX3 is a functional long-range target of obesity-associated variants within FTO (show FTO ELISA Kits) and represents a novel determinant of body mass and composition
IRX3 function may have a direct functional relationship to both obesity and type 2 diabetes.
barH-like homeobox-2 (show BARHL2 ELISA Kits) gene barhl2 (show BARHL2 ELISA Kits) acts downstream of orthodentricle-2 and together with iroquois-3 in establishment of the caudal (show CAD ELISA Kits) forebrain signaling center induced by Sonic Hedgehog (show SHH ELISA Kits)
Irx3 is transcriptionally induced by the Wnt (show WNT2 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits) signaling pathway during anteroposterior patterning of the neural axis.
Irx3 is the first gene known to be necessary and sufficient to specify nephron segment fate in vivo.
Irx3 is necessary for the postnatal maturation of the VCS (show EDC4 ELISA Kits), possibly via its interactions with Tbx5 (show TBX5 ELISA Kits) and Nkx2.5 (show NKX2-5 ELISA Kits).
Irx3 and Irx5 (Irx3/5) are essential in the initiating limb bud to specify progenitors of the femur, tibia, and digit 1.
postnatal Irx3 activity can be repressed by Irx5 (show IRX5 ELISA Kits)
Irx3 is critical for efficient conduction in this specialized tissue by antithetically regulating two gap junction-forming connexins
Irx3 signal is restricted to the somatic cell component of XX gonads and is present at a discreet period of ovarian development that ends at birth.
IRX3 is a member of the Iroquois homeobox gene family (see IRX1\; MIM 606197) and plays a role in an early step of neural development (Bellefroid et al., 1998
iroquois homeobox protein 3
, iroquois-class homeodomain protein IRX-3
, Iroquois related homeobox 3
, homeodomain protein IRXB1
, iroquois-class homeodomain protein IRX-1
, Iroquois homeobox protein 3
, homeobox transcription factor iroquois 3
, iroquois type homeobox
, iroquois-class homeodomain protein irx-3