Browse our OPA1 (OPA1) ELISA Kits

Full name:
Optic Atrophy 1 (Autosomal Dominant) ELISA Kits (OPA1)
On www.antibodies-online.com are 0 Optic Atrophy 1 (Autosomal Dominant) (OPA1) ELISA Kits from different suppliers available. Additionally we are shipping OPA1 Antibodies (78) and OPA1 Proteins (9) and many more products for this protein. A total of 90 OPA1 products are currently listed.
Synonyms:
1200011N24Rik, AI225888, AI847218, fk62d06, largeG, lilr3, MGM1, mKIAA0567, NPG, NTG, wu:fb77a10, wu:fk62d06, zgc:92092
list all ELISA KIts Gene Name GeneID UniProt
Mouse OPA1 OPA1 74143 P58281
Rat OPA1 OPA1 171116 Q2TA68
Human OPA1 OPA1 4976 O60313

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More ELISA Kits for OPA1 Interaction Partners

Mouse (Murine) Optic Atrophy 1 (Autosomal Dominant) (OPA1) interaction partners

  1. TNFR2 (show TNFRSF1B ELISA Kits) activation protects cardiac myocytes against stress by up-regulating OPA1 (show MED12 ELISA Kits) expression.

  2. OPA1 (show MED12 ELISA Kits) mutant mice are resistant to age- and diet-induced weight gain and insulin (show INS ELISA Kits) resistance, by mechanisms that involve activation of endoplasmic reticulum stress and secretion of fibroblast growth factor 21 (FGF21 (show FGF21 ELISA Kits)) from skeletal muscle, resulting in increased metabolic rates and improved whole-body insulin (show INS ELISA Kits) sensitivity.

  3. OPA1 (show MED12 ELISA Kits) modulates cristae morphology but is dispensable for cristae junction formation. Endogenous OPA1 (show MED12 ELISA Kits) and MIC60 show a physical interaction.

  4. Opa1 (show MED12 ELISA Kits) deficiency was associated with increased sensitivity to Ischemia-Reperfusion Injuries, imbalance in dynamic mitochondrial Ca2 (show CA2 ELISA Kits)+ uptake, and subsequent increase in NCX (show SLC8A1 ELISA Kits) activity.

  5. Whereas Parkin (show PARK2 ELISA Kits) has been reported to positively regulate the expression of OPA1 (show MED12 ELISA Kits) through NEMO (show IKBKG ELISA Kits), herein we found that PARK2 (show PARK2 ELISA Kits) overexpression did not modify the expression of OPA1 (show MED12 ELISA Kits).

  6. stress-induced OMA1 (show OMA1 ELISA Kits) activation and guanosine triphosphatase OPA1 (show MED12 ELISA Kits) cleavage limit mitochondrial fusion and promote neuronal death

  7. Data suggest that in a mouse model of neonatal hypoxic-ischemic brain injury, the expression of mitochondrial shaping proteins, such as OPA1 (show MED12 ELISA Kits) and Yme1L (show YME1L1 ELISA Kits), are altered; in vitro and in vivo, OPA1 (show MED12 ELISA Kits) is cleaved to shorter forms and Yme1L (show YME1L1 ELISA Kits) expression is reduced.

  8. results indicate that the OPA1 (show MED12 ELISA Kits)-dependent cristae remodeling pathway is a fundamental, targetable determinant of tissue damage in vivo.

  9. cristae shape amelioration by controlled Opa1 (show MED12 ELISA Kits) overexpression improves two mouse models of mitochondrial disease.

  10. unprocessed OPA1 (show MED12 ELISA Kits) is sufficient to maintain heart function, OMA1 (show OMA1 ELISA Kits) is a critical regulator of cardiomyocyte survival, and mitochondrial morphology and cardiac metabolism are intimately linked.

Human Optic Atrophy 1 (Autosomal Dominant) (OPA1) interaction partners

  1. OPA1 and cardiolipin cooperate in heterotypic mitochondrial inner membrane fusion.

  2. We propose that OPA1 stabilizes respiratory chain supercomplexes in a conformation that enables respiring mitochondria to compensate a drop in Deltapsim by an explosive matrix pH flash.

  3. We report the first cases of genetically confirmed OPA1-related autosomal-dominant optic atrophy from Singapore, including a novel mutation causing 'ADOA plus' syndrome.

  4. contrary to conventional notion, S-OPA1 is fully competent for maintaining mitochondrial energetics and cristae structure

  5. we analyzed ophthalmological data of a multicentre OPA1 patient cohort and found that women undergo more severe visual loss at adolescence and greater progressive thinning of the retinal nerve fibres than males. Thus, we disclosed a gender-dependent effect on ADOA severity, involving for the first time steroids and Muller glial cells, responsible for RGC degeneration.

  6. The gene signature of OPA1, CTSA (show CTSA ELISA Kits), NDUFA1 (show NDUFA1 ELISA Kits), STK10 (show STK10 ELISA Kits) and PRDX1 (show PRDX1 ELISA Kits) was able to identify patients post-implant with a sensitivity of 91% and a specificity of 86% in discrimination between post-implant group and healthy controls.

  7. The architecture of dendritic arborization in patients with OPA1 mutations is not known, but our data support the idea that loss of dendritic arborization may be involved in the pathogenesis of DOA rather than just population loss.

  8. OPA1 disclosed a de novo heterozygous deletion c.2012+4_2012+7delAGTA resulting in exon 18 and 19 skipping, which was not detected in healthy family members.

  9. This study demonstrated increased mitophagy and excessive mitochondrial fragmentation in primary human cultures associated with DOA plus due to biallelic OPA1 mutations.

  10. The present study identified novel compound heterozygous OPA1 mutations in a patient with recessive optic atrophy, sensorimotor neuropathy and congenital cataracts, indicating an expansion of the clinical spectrum of pathologies associated with OPA1 mutations.

Zebrafish Optic Atrophy 1 (Autosomal Dominant) (OPA1) interaction partners

  1. Opa1 is required for proper mitochondrial metabolism in early development

OPA1 Antigen Profile

Antigen Summary

This gene product is a nuclear-encoded mitochondrial protein with similarity to dynamin-related GTPases. It is a component of the mitochondrial network. Mutations in this gene have been associated with optic atrophy type 1, which is a dominantly inherited optic neuropathy resulting in progressive loss of visual acuity, leading in many cases to legal blindness. Multiple transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with OPA1

  • optic atrophy 1 (Opa1) Elisa Kit
  • optic atrophy 1 (autosomal dominant) (OPA1) Elisa Kit
  • optic atrophy 1 (human) (opa1) Elisa Kit
  • 1200011N24Rik Elisa Kit
  • AI225888 Elisa Kit
  • AI847218 Elisa Kit
  • fk62d06 Elisa Kit
  • largeG Elisa Kit
  • lilr3 Elisa Kit
  • MGM1 Elisa Kit
  • mKIAA0567 Elisa Kit
  • NPG Elisa Kit
  • NTG Elisa Kit
  • wu:fb77a10 Elisa Kit
  • wu:fk62d06 Elisa Kit
  • zgc:92092 Elisa Kit

Protein level used designations for OPA1

dynamin-like 120 kDa protein, mitochondrial , large GTP-binding protein , largeG , optic atrophy 1 homolog , optic atrophy protein 1 homolog , RN protein , optic atrophy 1 (autosomal dominant) , optic atrophy 1-like protein , dynamin-like guanosine triphosphatase , mitochondrial dynamin-like GTPase , optic atrophy protein 1

GENE ID SPECIES
74143 Mus musculus
171116 Rattus norvegicus
4976 Homo sapiens
424900 Gallus gallus
477129 Canis lupus familiaris
524142 Bos taurus
100172619 Pongo abelii
492332 Danio rerio
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