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anti-Human RIPPLY2 Antibodies:
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Functional analysis of the mouse Ripply2 ortholog.
suggest that Trim71 (show TRIM71 Antibodies) keeps priming steps of differentiation in check, which do not pre-require a loss of the pluripotency network in ES cells
Compound heterozygous mutations in RIPPLY2 are associated with segmentation defects of the vertebrae, a new gene for this condition.
Ripply2 represses Tbx6 (show TBX6 Antibodies) in a Mesp2 (show Mesp2 Antibodies)-independent manner, which contributes to the accurate segmental border formation.
Ripply2-Mesp2 (show Mesp2 Antibodies) negative-feedback loop is essential for the periodic generation of the rostro-caudal (show CAD Antibodies) polarity within a somite.
Two well-known E3 ubiquitin ligases, Trim25 (show TRIM25 Antibodies) (also called Efp (show TRIM25 Antibodies)) and Trim71 (show TRIM71 Antibodies) (also called Lin41 (show TRIM71 Antibodies)), are validated as RNA-binding proteins, revealing a potential link between RNA biology and protein-modification pathways.
conclusion was supported by analyses of Mesp2 (show Mesp2 Antibodies) KO and Ripply1/2 double KO embryos lacking rostral and caudal (show CAD Antibodies) properties, respectively
mLin41 acts as a temporal regulator to promote neural progenitor cell maintenance, not via the regulation of AGO2 (show EIF2C2 Antibodies) stability, but through FGF signaling.
Rostro-caudal pattern is established by dynamic interaction of Notch activity with two Mesp2 domains, which are defined in successive segmentation cycles by Notch, Tbx6 and Ripply1/2.
Defects in segmentation of the axial skeleton were observed in the ripply2 homozygous mutant mice.
findings show that Ripply2 is expressed in the anterior presomitic mesoderm and that it lies downstream of Wnt3a; data are consistent with Ripply2 functioning as a segment boundary determination gene during mammalian embryogenesis
May be involved in controlling the timing of organ formation during development (By similarity).
, ripply2 homolog
, E3 ubiquitin-protein ligase TRIM71
, lin-41 homolog
, protein lin-41 homolog
, tripartite motif-containing protein 71