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Dog (Canine) Polyclonal RPS7 Primary Antibody for WB - ABIN2774133
Chen, Zhang, Li, Wang, Li, Rayburn, Hill, Wang, Zhang: Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function. in Oncogene 2007
RPS7 role in cell proliferation in the context of Hepatitis B virus-related hepatocellular carcinoma.SIRT7 trans-represses RPS7 gene in the presence of HBx protein.
Low expression of RPS7 is associated with colorectal cancer.
Knockdown of RPS7 resulted in increased expression of P85alpha, P110alpha (show PIK3CA Antibodies), and AKT2 (show AKT2 Antibodies).
The study found two ribosomal proteins, RPS7 and RPL13A (show RPL13A Antibodies) that interact with the HMG (high-mobility group (show SSRP1 Antibodies)) box (show SSRP1 Antibodies) domain of SRY (show SRY Antibodies).
S7 binds to MDM2 (show MDM2 Antibodies), in vitro and in vivo, and the interaction between MDM2 (show MDM2 Antibodies) and S7 leads to modulation of MDM2 (show MDM2 Antibodies)-p53 (show TP53 Antibodies) binding by forming a ternary complex among MDM2 (show MDM2 Antibodies), p53 (show TP53 Antibodies) and S7.
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S7E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.
, ribosomal protein S7
, 40S ribosomal protein S7
, ribosomal protein S8 (rpS8B)
, 40S ribosomal protein S8
, ribosomal protein S8 (rpS8A)