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ectopic expression of miR (show MLXIP ELISA Kits)-25-3p reversed the epithelial-mesenchymal transition phenotype and sensitized cisplatin-resistant cervical cancer cells to cisplatin via targeting Sema4C
Data show that G-protein-coupled receptor (show ADRA1A ELISA Kits) kinase-interacting protein (show CIB1 ELISA Kits) 1 (GIT1) and semaphorin 4C (SEMA4C) were found to have putative microRNA miR (show MLXIP ELISA Kits)-138 binding sites in their 3' untranslated region (3'UTRs).
Suggest that up-regulation of miR (show MLXIP ELISA Kits)-125b or targeting Sema4C could serve as novel approaches to reverse chemotherapy resistance in breast cancers.
Data suggest that Erbin (show ERBB2IP ELISA Kits) can interact with Sema4C, and co-expression of Erbin (show ERBB2IP ELISA Kits) blocks the process of Sema4C-induced epithelial-mesenchymal transition.
There is a high expression of Sema4C in esophageal cancer, gastric cancer and rectal cancer, and expression is strongly correlated with lymphatic metastasis.
High Sema4C is associated with epithelial-mesenchymal transition and renal fibrosis.
we demonstrate that Sema4C is critical for optimal regulatory cytokine production in CD138 (show SDC1 ELISA Kits)(+) B cells.
Sema4C-Plexin B2 (show PLXNB2 ELISA Kits) signalling regulates ureteric branching
We have identified here Sema4C and Sema4G (show SEMA4G ELISA Kits) as candidate ligands for Plexin-B2 (show PLXNB2 ELISA Kits)
Plexin-B2 (show PLXNB2 ELISA Kits) and Sema4C are potential regulators of the vascular and endocrine system.
Results suggest a putative role of Sema4C during neurogenesis both in vivo and in vitro.
Sema4C-mediated interaction among myoblasts plays an important role in terminal myogenic differentiation
Sema4C promotes terminal myogenic differentiation in a p38 MAPK (show MAPK14 ELISA Kits)-dependent manner.
Cell surface receptor for PLXNB2 that plays an important role in cell-cell signaling. PLXNB2 binding promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal brain development, axon guidance and cell migration. Probable signaling receptor which may play a role in myogenic differentiation through activation of the stress- activated MAPK cascade.
, sema I
, semaphorin I
, semaphorin-C-like 1