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findings suggest that SOX11 is a potential biomarker for ductal carcinoma in situ lesions containing cells harbouring distinct biological features that are likely to progress to invasive breast cancer.
SOX11 antigen can be reliably detected in decalcified tissue bone marrow tissue from mantle cell lymphoma patients.
results suggest that SOX11 promotes MCL (show FH ELISA Kits) homing and invasion and increases CAM (show CALM1 ELISA Kits)-DR through the direct regulation of CXCR4 (show CXCR4 ELISA Kits) and FAK (show PTK2 ELISA Kits) expression and FAK (show PTK2 ELISA Kits)/PI3K (show PIK3CA ELISA Kits)/AKT (show AKT1 ELISA Kits) pathway activation, contributing to a more aggressive phenotype.
In this study we screened the transcriptional profiles of 70 MCL patients for SOXC cluster and miR17, miR18a, miR19b and miR92a, from the miR-17-92 cluster. Gene expression analysis showed higher SOX11 and SOX12 levels compared to SOX4 (P = 0.0026). Moreover we found a negative correlation between the expression of SOX11 and SOX4
Analysis of 28 other patients with CHARGE showed no SOX11 copy number changes or pathogenic sequence variants. To our knowledge, this child's chromosomal abnormality is unique and represents the first co-occurrence of duplication 2p25 and clinical features of CHARGE syndrome
SOX11 immunohistochemistry could be a useful adjunct in distinguishing secondary cutaneous mantle cell lymphoma from primary cutaneous B-cell lymphomas.
BLIMP1 (show PRDM1 ELISA Kits) and XBP1 (show XBP1 ELISA Kits) expression was also significantly more frequent in SOX11-negative than in -positive cases
SOX11 is useful in differentiating cyclin D1 (show CCND1 ELISA Kits)-positive diffuse large B-cell lymphoma from mantle cell lymphoma
SOX11 deletion or mutation can present with a Coffin-Siris phenotype
The ability of sox11 to reduce effector caspase (show CASP3 ELISA Kits) activity was also reflected in its capacity to reduce cell death following toxic insult. Interestingly, other sox (show PIPOX ELISA Kits) proteins also had the ability to reduce caspase-6 (show CASP6 ELISA Kits) activity but to a lesser extent than sox11
SOX11 represents a useful prognostic marker in mantle cell lymphoma.
Sox11 can induce substantial axon regeneration. Transcriptome profiling indicated that Sox11 activates genes involved in cytoskeletal remodeling and axon growth. Remarkably, alpha-RGCs, which preferentially regenerate following treatments such as Pten deletion, were killed by Sox11 overexpression. Thus, Sox11 promotes regeneration of non-alpha-RGCs, which are refractory to Pten deletion-induced regeneration.
These findings indicate that suppression of dendritic morphogenesis by Sox11 during radial migration is crucial for the formation of the cerebral cortex.
Following elevation of the palatal shelves (E14.5), Sox2 (show SOX2 ELISA Kits), Sox11 and Sox21 (show SOX21 ELISA Kits) expression was present in the midline epithelial seam. We thus identify dynamic spatio-temporal expression of Sox (show QSOX1 ELISA Kits) gene family during the process of palatogenesis
Sox11 directly regulates the expression of Fgf9; ablation of the Sox11 gene results in clefting of the secondary palate resembling the Pierre Robin sequence.
SOXC proteins act cell- and non-cell-autonomously in perichondrocytes and chondrocytes to establish noncanonical WNT (show WNT2 ELISA Kits) signaling crosstalk essential for growth plate induction and control
Sox11 and Sox4 are not redundant in promoting neuronal differentiation in the cortex, but rather act in overlapping and discrete populations of neurons
Fetal Sox11 disruption lead to hypoplastic lungs, ventricular septation defects, abdominal defects, skeletal malformations, decreased birth weight and postnatal lethality.
These data identify Sox11 as a key transcription factor that can confer an elevated innate regenerative capacity to CNS neurons.
Sox11 expression was high in fetal.
Binds to the DNA sequence 5'-AACAAT-3'. Plays a role together with nlk in neural induction during early embryogenesis (By similarity).
, transcription factor Sox-11
, SRY (sex determining region Y)-box 11
, Sox11 transcription factor
, transcription factor SOX-11
, SRY (sex-determining region Y)-box 11
, SRY-related HMG-box gene 11
, SRY-box containing gene 11
, SRY (sex determining region Y)-box 11 b
, Transcription factor Sox-13
, transcription factor Sox-11-B