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These findings reveal a novel layer of regulation for MST2 in mitosis and its role in tumorigenesis.
TNFAIP8 regulates Hippo (MST1/2) signaling through its interaction with LATS1.
Data suggest that Hippo (MST1 (show MST1 ELISA Kits)/2 protein kinases) - Yes associated protein 1 (YAP (show YAP1 ELISA Kits)) pathway involved in carcinogenesis of pancreatic cancer and in the inhibition effect of stiehopus japonieus acidic mucopolysaccharide (SJAMP) to the proliferation of pancreatic cancer cell.
H-ras (show HRAS ELISA Kits), via an Erk (show EPHB2 ELISA Kits)-dependent mechanism, downregulates Mst1 (show MST1 ELISA Kits)/Mst2 activity by inducing the formation of inactive Mst1 (show MST1 ELISA Kits)/Mst2 heterodimers.
Results show that STK3 is targeted by Casp6 (show CASP6 ELISA Kits) and demonstrate that alterations in STK3 protein expression levels and post-translational modifications are detected in a cellular model of HD and caspase (show CASP3 ELISA Kits)-mediated generation of STK3 fragments observed under conditions of stress in cells expressing mhtt.
using an Mst2 mutation that disrupts homotypic dimerization, we showed that the monomeric Mst2-SARAH domain could form a stable complex of 1:1 stoichiometric ratio with WW45 (show SAV1 ELISA Kits) refolded under acidic pH.
The MST1/2-SAV1 complex, a core component of the Hippo pathway, promotes ciliogenesis.
These results suggest that AIF (show AIFM1 ELISA Kits) downregulation is a common event in kidney tumor development. AIF (show AIFM1 ELISA Kits) loss may lead to decreased STK3 activity, defective apoptosis and malignant transformation
Hippo and Yap (show YAP1 ELISA Kits) regulate cardiomyocyte death and regeneration.
results reveal a novel role of Mst2 in stress-dependent cardiac hypertrophy and remodeling in the adult mouse and likely human heart
It is involved in apoptosis and serine/threonine kinase 3 (STK3 (show PKN1 ELISA Kits)) is a recently identified caspase-6 (show CASP6 ELISA Kits) substrate.
Using a standard two-thirds partial hepatectomy (PH) model in young and aged mice, the activity of the core kinases MST1 (show MST1 ELISA Kits) and LATS1 increased during the early hypertrophic phase and returned to steady state levels in the proliferative phase, coinciding with activation of YAP1 (show YAP1 ELISA Kits) target genes and hepatocyte proliferation.
Studies indicate that Hippo (Hpo (show GFER ELISA Kits); MST1 (show MST1 ELISA Kits)/2 in mammals) signaling pathway plays a central role in the cell fate-specification process.
Mst2 is involved in bone homeostasis, functioning as a reciprocal regulator of osteoclast and osteoblast differentiation through the NF-kappaB (show NFKB1 ELISA Kits) pathway
the TLR-Mst1 (show MST1 ELISA Kits)-Mst2-Rac (show AKT1 ELISA Kits) signaling axis is critical for effective phagosome-mitochondrion function and bactericidal activity
These data indicate that that inhibition of mammalian sterile 20-like kinase 1 (show STK4 ELISA Kits) rescued cardiac fibrosis and myocardial dysfunction in chronic beta1-adrenergic receptor stimulation-induced cardiomyopathy
Phosphorylation of LC3 (show MAP1LC3A ELISA Kits) by the STK3 (show PKN1 ELISA Kits) and STK4 is essential for autophagy.
These results identify MST2, not MST1 (show MST1 ELISA Kits), as a critical regulator of caspase (show CASP3 ELISA Kits)-mediated photoreceptor cell death in the detached retina and indicate its potential as a future neuroprotection target.
Mst1 (show MST1 ELISA Kits)/2 regulate placental development by control of trophoblast cell differentiation and labyrinthine vasculature at midgestation and Mst1 (show MST1 ELISA Kits)/2 control labyrinth morphogenesis in trophoblast- and fetal endothelial-dependent manners.
This gene encodes a serine/threonine protein kinase activated by proapoptotic molecules indicating the encoded protein functions as a growth suppressor. Cleavage of the protein product by caspase removes the inhibitory C-terminal portion. The N-terminal portion is transported to the nucleus where it homodimerizes to form the active kinase which promotes the condensation of chromatin during apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene.
, STE20-like kinase MST2
, mammalian STE20-like protein kinase 2
, serine/threonine kinase 3 (STE20 homolog, yeast)
, serine/threonine kinase 3 (Ste20, yeast homolog)
, serine/threonine-protein kinase 3
, serine/threonine-protein kinase Krs-1
, protein kinase homolog
, serine/threonine kinase 3 (STE20 homolog)