Browse our T, Brachyury Homolog (Mouse) Proteins (T)

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T, Brachyury Homolog (Mouse) Proteins (T)
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Synonyms:
bra, brachyury, bu, CH-T, cou, D17Mit170, Low, Lr, me75, ntl, t, T1, ta, TFT, Tl2, Tl3, X-bra, xbra, Xbrachyury
list all proteins Gene Name GeneID UniProt
Mouse T T 20997 P20293
Human T T 6862 O15178
T    

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T, Brachyury Homolog (Mouse) Proteins (T) by Origin

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Mouse (Murine) T, Brachyury Homolog (Mouse) (T) interaction partners

  1. Wnt3a (show WNT3A Proteins), which regulate cell growth, were also expressed strongly during E12.5-E13.5. On the other hand, cleft formation and branching morphogenesis was suppressed by knockdown of Brachyury (show TBX1 Proteins) gene, suggesting that Brachyury (show TBX1 Proteins) plays a central role in regulating cell growth and cleft formation in early-stage embryonic mouse salivary gland development

  2. Epiblast stem cells are discriminated by the expression of a specific marker T (Brachyury (show TBX1 Proteins)) into two populations.

  3. data confirmed that Brachyury (show TBX1 Proteins) might contribute to hypoxia-induced EMT (show ITK Proteins) of breast cancer and trigger HIF-1alpha (show HIF1A Proteins) expression via PTEN/Akt (show AKT1 Proteins) signaling

  4. Results showed that the expression levels of HDAC1 (show HDAC1 Proteins) and 3 are decreased gradually during embryonic stem cells (ESCs (show NR2E3 Proteins)) mesodermal differentiation and interact physically with Bry protein, which is critical for mesodermal lineage commitment.

  5. Epithelial-to-mesenchymal transition (EMT (show ITK Proteins)) initiates the controlled differentiation of embryonic stem cells, which is both fuelled and terminated by the action of brachyury (show TBX1 Proteins), whose expression is dependent on the EMT (show ITK Proteins) and beta-catenin (show CTNNB1 Proteins) activity.

  6. results thus chart a comprehensive map of the Brachyury (show TBX1 Proteins)-mediated gene-regulatory network and how it influences in vivo developmental homeostasis and coordination

  7. T (BRACHYURY (show TBX1 Proteins)), a classical and conserved mesodermal factor, was essential for robust activation of Blimp1 (show PRDM1 Proteins) and Prdm14 (show PRDM14 Proteins), two of the germline determinants.

  8. In vivo knockdown of Brachyury results in skeletal defects and urorectal malformations resembling caudal regression syndrome

  9. UTX (show KDM6A Proteins) controls mesoderm differentiation and Brachyury (show TBX1 Proteins) expression independent of H3K27 demethylase (show MBD2 Proteins) activity; UTX (show KDM6A Proteins) and UTY are functionally redundant in ES cell differentiation and early embryonic development

  10. We found Tcf3 (show TCF7L1 Proteins) as a potential target of gene repression by Nkx1-2 (show NKX1-2 Proteins), and the down-regulation of Tcf3 (show TCF7L1 Proteins) was partly required for effective activation of Brachyury (show TBX1 Proteins) by Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling

Xenopus laevis T, Brachyury Homolog (Mouse) (T) interaction partners

  1. DN-Xbra inhibits PV.1 expression and that the suppression of PV.1 reduces overall BMP signaling by inducing chordin (show CHRD Proteins) and goosecoid expression.

  2. EphA4-dependent Brachyury (show TBX1 Proteins) expression is required for dorsal mesoderm involution in the Xenopus gastrula.

  3. This is the first report to demonstrate that Brachyury (show TBX1 Proteins) might affect the cytoskeletal structure through regulating the expression of an intermediate filament protein (show INA Proteins), vimentin.

  4. Data suggest a dual regulation in which XESR5 produces a competent area for mesoderm formation by suppressing the gene expression of XESR1 (show ESR1 Proteins), while XESR1 (show ESR1 Proteins) sharpens the boundary of Xbra expression.

  5. controls the early homeobox (show PRRX1 Proteins) gene expression domain in the animal-vegetal direction

  6. findings reveal that the N-terminal domain that restricts the inducing activity of Xbra interacts with Smad1 (show SMAD1 Proteins)

  7. Embryo elongation can occur through the synergistic effect(s) of the organizer molecule chordin (show CHRD Proteins), and the 'verall posteriorizing molecule Xbra.

  8. AP-2rep (show KLF12 Proteins) is involved in the morphogenesis of the mesoderm at the gastrula stage, via the brachyury (show TBX1 Proteins) and/or Wnt (show WNT2 Proteins) pathways.

Human T, Brachyury Homolog (Mouse) (T) interaction partners

  1. rs2305089 variant in T (brachyury (show TBX1 Proteins)) gene is associated with response to therapy in Spinal column chordoma.

  2. Brachyury (show TBX1 Proteins) was significantly associated with estrogen receptor (show ESR1 Proteins) positive and human epidermal growth factor receptor (show EGFR Proteins) 2 negative status; further study would be needed to clarify how it affects treatment prognosis.

  3. Brachyury (show TBX1 Proteins) is a candidate marker for predicting the clinical efficacy of tamoxifen.

  4. Overexpression of Brachyury (show TBX1 Proteins) in the cytoplasm is predictive of poor prognosis in gastrointestinal stromal tumors.

  5. Results showed that the high expression of SMC1 (show SMC1A Proteins) often promoted epithelial-mesenchymal transition, accompanied by the enhanced expression of Brachyury (show TBX1 Proteins) in triple-negative breast cancer cells.

  6. Brachyury (show TBX1 Proteins) expression promotes lung cancer cell proliferation and invasion, and correlates with reduced patient survival.

  7. Nuclear brachyury (show TBX1 Proteins) expression is prevalent in embryonal carcinoma, seminoma, and small cell carcinoma of the lung but very rare in common carcinomas, sarcomas, and melanoma.

  8. Elevated Brachyury (show TBX1 Proteins) facilitates hepatocellular carcinoma metastasis by promoting EMT (show ITK Proteins) via PTEN/Akt (show AKT1 Proteins)/Snail (show SNAI1 Proteins)-dependent pathway.

  9. we found that Brachyury (show TBX1 Proteins) expression was inversely correlated with CCL2 (show CCL2 Proteins) and CCL4 (show CCL4 Proteins) expression in human lung tumors

  10. Brachyury (show TBX1 Proteins) plays an important role in regulating TGF beta 1 (show TGFB1 Proteins)-mediated renal epithelial mesenchymal transition and could be an attractive target for progression of renal disease therapies

T, Brachyury Homolog (Mouse) (T) Protein Profile

Protein Summary

The protein encoded by this gene is an embryonic nuclear transcription factor that binds to a specific DNA element, the palindromic T-site. It binds through a region in its N-terminus, called the T-box, and effects transcription of genes required for mesoderm formation and differentiation. The protein is localized to notochord-derived cells. Two transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with T, Brachyury Homolog (Mouse) (T)

  • brachyury (T)
  • T, brachyury homolog (t-a)
  • T, brachyury homolog (mouse) (T)
  • bra protein
  • brachyury protein
  • bu protein
  • CH-T protein
  • cou protein
  • D17Mit170 protein
  • Low protein
  • Lr protein
  • me75 protein
  • ntl protein
  • t protein
  • T1 protein
  • ta protein
  • TFT protein
  • Tl2 protein
  • Tl3 protein
  • X-bra protein
  • xbra protein
  • Xbrachyury protein

Protein level used designations for T

brachyury protein , brachyury-like 2 , brachyury-like 3 , low ratio , protein T , T, brachyury homolog a , brachyury (T) , T brachyury homolog , T brachyury protein

GENE ID SPECIES
20997 Mus musculus
399275 Xenopus laevis
6862 Homo sapiens
395782 Gallus gallus
403653 Canis lupus familiaris
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