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Flow cytometry analysis showed that depletion of TCTN1 could cause cell cycle arrest at the G2/M phase. This indicates that TCTN1 may be crucial for CRC (show CALR ELISA Kits) cell growth.
High TCTN1 expression is associated with Pancreatic Cancer.
These findings confirmed the direct association between the TCTN1 gene and prostate cancer growth in vitro.
These data suggest TCTN1 is essential for glioma cell viability, and dysregulation of TCTN1 may play a key role in glioma tumorigenesis.
TCTN1 may serve as a novel prognostic factor and a potential therapeutic target for glioblastoma.
Mutations in Tctn1 is associated with ciliopathies.
These results suggest that Tctn1, Tctn2 (show TCTN2 ELISA Kits), and Tctn3 (show TCTN3 ELISA Kits) are functionally divergent with respect to their role in ciliogenesis and Hedgehog (show SHH ELISA Kits) signaling but conserved in neural tube patterning and Gli3 (show GLI3 ELISA Kits) processing.
Loss of Tctn1 is associated with ciliopathies.
During neural tube development, mouse Tectonic is required for formation of the most ventral cell types and for full Hedgehog (show SHH ELISA Kits) (Hh) pathway activation. Tectonic plays an additional role in repressing Hh pathway activity.
This gene encodes a member of the tectonic family of secreted and transmembrane proteins. The orthologous gene in mouse is required for formation of most ventral cell types. It functions downstream of smoothened and rab23 to modulate hedgehog signal transduction. Multiple transcript variants encoding different isoforms have been found for this gene.
tectonic family member 1
, tectonic 1