Browse our WT1 Proteins (WT1)

On www.antibodies-online.com are 19 Wilms Tumor 1 (WT1) Proteins from 6 different suppliers available. Additionally we are shipping WT1 Antibodies (295) and WT1 Kits (16) and many more products for this protein. A total of 339 WT1 products are currently listed.
Synonyms:
AWT1, CWT1, D630046I19Rik, EWS-WT1, GUD, NPHS4, si:ch211-160j6.3, WAGR, WIT-2, WT, Wt-1, wt1, WT33, XeWT1, xwt1, XWT1a, XWT1b, zgc:152697
list all proteins Gene Name GeneID UniProt
WT1 7490 P19544
WT1 24883 P49952
Mouse WT1 WT1 22431  

WT1 Proteins (WT1) by Origin

More Proteins for WT1 Interaction Partners

Xenopus laevis Wilms Tumor 1 (WT1) interaction partners

  1. WT1 interference with Wnt (show WNT2 Proteins) signaling represents an important mode of its action relevant to the suppression of tumor growth and guidance of development.

Human Wilms Tumor 1 (WT1) interaction partners

  1. WT1 acts as a tumour promoter in osteosarcoma and it could be a potential therapeutic target.

  2. a novel role of WT1 mutations in the deregulation of epigenetic programs in leukemic cells through its interaction with TET proteins (Review)

  3. Mutations of WT1 gene is associated with Acute myeloid leukemia (show BCL11A Proteins).

  4. The findings of the present study indicate that all females with SRNS-FSGS (show ACTN4 Proteins) should be screened for WT1 gene mutation to diagnose whether they have FS for possible gonadectomy.

  5. Denys-Drash syndrome associated WT1 glutamine 369 mutants have altered sequence-preferences in DNA binding and altered responses to epigenetic cytosine modifications.

  6. Sequence variants in NPHS4 were identified in families with CRB2 (show CRB2 Proteins)-related syndrome.

  7. WT1 modulates Akt (show AKT1 Proteins)/JNK (show MAPK8 Proteins) signaling pathway mediated autophagy by controlling the expression of growth arrest-specific 1 (Gas1 (show GAS1 Proteins)).

  8. WT1 knock-down gave a corresponding decrease in QPRT (show QPRT Proteins) gene and protein expression. Chromatin-immunoprecipitation revealed WT1 binding to a conserved site in the first intron of the QPRT (show QPRT Proteins) gene.

  9. WT1 helps to differentiate Wilms' tumour from other paediatric renal tumours. It may help in differentiating the two subgroups of Wilms' tumour which have distinct molecular pathogenesis and biological behaviour, however, further prospective studies are required for validation of this hypothesis.

  10. a high WT1 mutation rate was observed in this group of steroid-resistant nephrotic syndrome patients

Pig (Porcine) Wilms Tumor 1 (WT1) interaction partners

  1. Sodium butyrate-induced hyperacetylation up-regulates WT1 expression in porcine kidney fibroblasts, suggesting the involvement of histone acetylation in the transcriptional modulation of WT1 in porcine kidney cells.

  2. Results indicate that WT1 plays important roles in the development of porcine preimplantation embryos, but not in oocyte maturation.

  3. WT1 is expressed in porcine fetal fibroblasts, but the levels of expression were much lower compared to porcine primary kidney fibroblasts and swine testis, and WT1 is essential for the maintenance of development and survival of porcine fetal fibroblasts

Mouse (Murine) Wilms Tumor 1 (WT1) interaction partners

  1. WT1 is required for the lineage specification of both Sertoli and granulosa cells by repressing Sf1 (show SF1 Proteins) expression. Without Wt1, the expression of Sf1 (show SF1 Proteins) was upregulated and the somatic cells differentiated into steroidogenic cells instead of supporting cells.

  2. study provides novel insights into the role of WT1 and GATA4 (show GATA4 Proteins) during the sex differentiation phase and represents an approach that can be applied to assess other proteins with as yet unknown functions during gonadal development

  3. WT1 regulates reporter gene expression through interaction with 3' UTR-binding sites

  4. These results indicate that Osr1 (show OSR1 Proteins) and Wt1 act synergistically to regulate nephron endowment by controlling metanephric mesenchyme specification during early nephrogenesis.

  5. Wt1 regulates the development of FLC.

  6. WT1 stimulates IGFBP5 (show IGFBP5 Proteins) transcription in developing murine kidney.

  7. Over expression of miR (show MLXIP Proteins)-206 promotes podocyte injury via downregulation of WT1, which provides a new pathogenic mechanism for Focal segmental glomerulosclerosis and miR (show MLXIP Proteins)-206 may be a potential therapeutic target.

  8. by targeting WT1, miR743a suppresses the proliferation of MM cells in vitro, and probably possesses vital functions in kidney development and kidneyassociated diseases.

  9. To test the tumorigenic potential of different cell types in the developing kidney, we used kidney progenitor-specific Cre recombinase alleles to introduce Wt1 and Ctnnb1 mutations, two alterations observed in Wilms tumor, into embryonic mouse kidney, with and without biallelic Igf2 expression, another alteration that is observed in a majority of tumors

  10. miR (show MLXIP Proteins)-125a is a regulatory molecule that suppresses WT1 expression via a direct interaction with the 3'UTR of WT1 mRNA and miR (show MLXIP Proteins)-125a knockout mice induce myeloproliferative disease (MPD (show MVD Proteins)) and urogenital abnormalities

Zebrafish Wilms Tumor 1 (WT1) interaction partners

  1. While wt1a has a more fundamental and early role in pronephros development and is essential for the formation of glomerular structures, wt1b functions at later stages of nephrogenesis.

WT1 Protein Profile

Protein Summary

This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilm's tumors. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the maternal and paternal alleles in different tissues. Multiple transcript variants have been described. In several variants, there is evidence for the use of a non-AUG (CUG) translation initiation site upstream of and in-frame with the first AUG. Authors of PMID:7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated.

Alternative names and synonyms associated with WT1

  • Wilms tumor 1 (WT1)
  • Wilms tumor 1 (wt1-a)
  • Wilms tumor 1 (wt1)
  • Wilms tumor 1 (LOC100346776)
  • Wilms tumor protein (wt1)
  • Wilms tumor 1 (wt1-b)
  • Wilms tumor 1 (Wt1)
  • Wilms tumor 1 homolog (Wt1)
  • wilms tumor 1b (wt1b)
  • AWT1 protein
  • CWT1 protein
  • D630046I19Rik protein
  • EWS-WT1 protein
  • GUD protein
  • NPHS4 protein
  • si:ch211-160j6.3 protein
  • WAGR protein
  • WIT-2 protein
  • WT protein
  • Wt-1 protein
  • wt1 protein
  • WT33 protein
  • XeWT1 protein
  • xwt1 protein
  • XWT1a protein
  • XWT1b protein
  • zgc:152697 protein

Protein level used designations for Wilms Tumor 1 Proteins (WT1)

Wilms tumor 1 , Wilms tumor protein homolog A , Wilms tumor protein homolog , Wilms tumor protein , amino-terminal domain of EWS , last three zinc fingers of the DNA-binding domain of WT1 , Wilm's tumor suppressor , Wilms tumor protein homolog B , Chick Wilm's tumour protein , Wilms tumor suppressor protein 1b

GENE ID SPECIES
782183 Bos taurus
280959 Bos taurus
373588 Xenopus laevis
614584 Bos taurus
696061 Macaca mulatta
737987 Pan troglodytes
100101227 Ovis aries
100216184 Xenopus (Silurana) tropicalis
100346776 Oryctolagus cuniculus
100380493 Salmo salar
7490 Homo sapiens
378664 Xenopus laevis
396139 Gallus gallus
609253 Canis lupus familiaris
397338 Sus scrofa
24883 Rattus norvegicus
22431 Mus musculus
568416 Danio rerio
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