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Human Polyclonal SPHK2 Primary Antibody for IHC (p), WB - ABIN391348
Liu, Sugiura, Nava, Edsall, Kono, Poulton, Milstien, Kohama, Spiegel: Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform. in The Journal of biological chemistry 2000
Show all 8 Pubmed References
Human Polyclonal SPHK2 Primary Antibody for IF (p), IHC (p) - ABIN748613
Zhang, Li, Yuan, Zhao: Hypoxic preconditioning protects cardiomyocytes against hypoxia/reoxygenation-induced cell apoptosis via sphingosine kinase 2 and FAK/AKT pathway. in Experimental and molecular pathology 2016
Show all 3 Pubmed References
Human Polyclonal SPHK2 Primary Antibody for IHC (p), WB - ABIN391349
Shutler, Glassco, Kang, Korneluk, Mueller: Genomic structure of the human D-site binding protein (DBP) gene. in Genomics 1996
Show all 4 Pubmed References
Sk1 (show SPHK1 Antibodies) and Sk2 (show KCNN2 Antibodies) are not redundant in biological function and are essential for diverse physiological functions in Drosophila
The analysis suggests that the catalytic function and regulation of SPHK1 (show SPHK1 Antibodies) and SPHK2 might be dependent on their conformational mobility. (Review)
In this study, we describe the findings that overexpression of SphK2 promotes chemoresistance in non-small cell lung cancer (NSCLC) cells. Inhibition of SphK2 might be considered as a strategy in NSCLC treatment with gefitinib
the pathogenesis of CRC (show CALR Antibodies) maybe mediated by SphK2, and SphK2 could represent a selective target for the molecularly targeted treatments of CRC (show CALR Antibodies)
data suggest that in vitro inhibition of SK-2 (show KCNN2 Antibodies), can compromise the integrity of the EC monolayer
ABC294640 may reduce the proliferative capacity of castration-resistant prostate cancer cells through inhibition of both sphingosine kinase 2 and dihydroceramide desaturase (show DEGS1 Antibodies).
increased SK and SPL (show SGPL1 Antibodies) mRNA expression along with reduced sphingosine 1-phosphate levels were more commonly observed in hepatocellular carcinoma tissues.
Because of the unique relationship observed after serum depletion, we examined effects of siRNA for SPHK2, and found the role of SPHK2 as a growth or survival factor but not a cell proliferation inhibitor in FCS(-) culture
Targeting of SphK2 by ABC294640 potently inhibits colorectal cancer cell growth both in vitro and in vivo.
results define new mechanistic insights for EGF (show EGF Antibodies)-mediated invasion and novel actions of SK2 (show KCNN2 Antibodies)
These data illuminate a novel survival mechanism and potential therapeutic target for KSHV-infected endothelial cells: SphK2-associated maintenance of viral latency
Taken together, we conclude that antamiR-613 protects neuronal cells from OGDR probably via inducing SphK2 expression.
data suggest that in vitro inhibition of SK-2 (show PAPSS2 Antibodies), can compromise the integrity of the EC monolayer
Results show that Sphk2/S1P (show S1PR1 Antibodies) has an important role to play in the survival of the dopaminergic neurons, in the pathogenesis of Parkinson's disease
Demonstrate that Sphk2 is the major Sphk (show SPHK1 Antibodies) isoform responsible for the generation of S1P (show S1PR1 Antibodies) in platelets and plays a pivotal intrinsic role in the control of platelet activation.
transcriptionally up-regulated by acute endoplasmic reticulum stress through activation of ATF4 (show ATF4 Antibodies) and improves perturbed hepatic glucose and fatty acid metabolism
These results strongly indicate that autophagy is involved in isoflurane preconditioning both in vivo and in vitro and that SPK2 contributes to preconditioning-induced autophagy, possibly by disrupting the Beclin 1 (show BECN1 Antibodies)/Bcl-2 (show BCL2 Antibodies) interaction.
SK1 (show SPHK1 Antibodies) and SK2 (show PAPSS2 Antibodies) down-regulation reduces the motility of satellite cells.
attenuation of Sphk1 (show SPHK1 Antibodies), 2 activity, particularly Sphk2, leads to increased intracellular sphingolipids and autophagy in macrophages.
Sphk2 provides the source of intracellular S1P (show S1PR1 Antibodies) that controls thrombopoiesis, which is associated with Src (show SRC Antibodies) family kinases expression and activity in megakaryocytes.
sphingosine kinase-2 has a role in a murine model of lupus nephritis
This gene encodes one of two sphingosine kinase isozymes that catalyze the phosphorylation of sphingosine into sphingosine 1-phosphate. Sphingosine 1-phosphate mediates many cellular processes including migration, proliferation and apoptosis, and also plays a role in several types of cancer by promoting angiogenesis and tumorigenesis. The encoded protein may play a role in breast cancer proliferation and chemoresistance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
, sphingosine kinase 2
, sphingosine kinase
, sphingosine kinase II
, sphingosine kinase 2-like
, sphingosine kinase type 2
, SK 2
, SPK 2
, Spk2, Sk2