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Sk1 and Sk2 are not redundant in biological function and are essential for diverse physiological functions in Drosophila
The analysis suggests that the catalytic function and regulation of SPHK1 (show SPHK1 Proteins) and SPHK2 might be dependent on their conformational mobility. (Review)
In this study, we describe the findings that overexpression of SphK2 promotes chemoresistance in non-small cell lung cancer (NSCLC) cells. Inhibition of SphK2 might be considered as a strategy in NSCLC treatment with gefitinib
the pathogenesis of CRC (show CALR Proteins) maybe mediated by SphK2, and SphK2 could represent a selective target for the molecularly targeted treatments of CRC (show CALR Proteins)
data suggest that in vitro inhibition of SK-2, can compromise the integrity of the EC monolayer
ABC294640 may reduce the proliferative capacity of castration-resistant prostate cancer cells through inhibition of both sphingosine kinase 2 and dihydroceramide desaturase (show DEGS1 Proteins).
increased SK and SPL (show SGPL1 Proteins) mRNA expression along with reduced sphingosine 1-phosphate levels were more commonly observed in hepatocellular carcinoma tissues.
Because of the unique relationship observed after serum depletion, we examined effects of siRNA for SPHK2, and found the role of SPHK2 as a growth or survival factor but not a cell proliferation inhibitor in FCS(-) culture
Targeting of SphK2 by ABC294640 potently inhibits colorectal cancer cell growth both in vitro and in vivo.
results define new mechanistic insights for EGF-mediated invasion and novel actions of SK2
These data illuminate a novel survival mechanism and potential therapeutic target for KSHV-infected endothelial cells: SphK2-associated maintenance of viral latency
Results show that Sphk2/S1P (show S1PR1 Proteins) has an important role to play in the survival of the dopaminergic neurons, in the pathogenesis of Parkinson's disease
Demonstrate that Sphk2 is the major Sphk (show SPHK1 Proteins) isoform responsible for the generation of S1P (show S1PR1 Proteins) in platelets and plays a pivotal intrinsic role in the control of platelet activation.
transcriptionally up-regulated by acute endoplasmic reticulum stress through activation of ATF4 (show ATF4 Proteins) and improves perturbed hepatic glucose and fatty acid metabolism
These results strongly indicate that autophagy is involved in isoflurane preconditioning both in vivo and in vitro and that SPK2 contributes to preconditioning-induced autophagy, possibly by disrupting the Beclin 1 (show BECN1 Proteins)/Bcl-2 (show BCL2 Proteins) interaction.
SK1 and SK2 down-regulation reduces the motility of satellite cells.
attenuation of Sphk1 (show SPHK1 Proteins), 2 activity, particularly Sphk2, leads to increased intracellular sphingolipids and autophagy in macrophages.
Sphk2 provides the source of intracellular S1P (show S1PR1 Proteins) that controls thrombopoiesis, which is associated with Src (show SRC Proteins) family kinases expression and activity in megakaryocytes.
sphingosine kinase-2 has a role in a murine model of lupus nephritis
The function of SphK1 (show SPHK1 Proteins) and SphK2 can be interchangeable in mast cells and is species and cell type determined.
This gene encodes one of two sphingosine kinase isozymes that catalyze the phosphorylation of sphingosine into sphingosine 1-phosphate. Sphingosine 1-phosphate mediates many cellular processes including migration, proliferation and apoptosis, and also plays a role in several types of cancer by promoting angiogenesis and tumorigenesis. The encoded protein may play a role in breast cancer proliferation and chemoresistance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
, sphingosine kinase 2
, sphingosine kinase
, sphingosine kinase II
, sphingosine kinase 2-like
, sphingosine kinase type 2
, SK 2
, SPK 2
, Spk2, Sk2