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Human PGF Protein expressed in Escherichia coli (E. coli) - ABIN413725
Ding, Huang, Song, Gao, Yuan, Wang, Cai, Fu, Luo: NFAT1 mediates placental growth factor-induced myelomonocytic cell recruitment via the induction of TNF-alpha. in Journal of immunology (Baltimore, Md. : 1950) 2010
Rat (Rattus) PGF Protein expressed in Escherichia coli (E. coli) - ABIN2126310
Zhang, Zhao, Yuan, Wu, Jiang, Luo, Zhao: Knockdown of placental growth factor (PLGF) mitigates hyperoxia-induced acute lung injury in neonatal rats: Suppressive effects on NFκB signaling pathway. in International immunopharmacology 2016
Lower maternal PlGF concentration is associated with intrapartum fetal compromise and poorer condition of the newborn. Maternal PlGF levels may be useful as a component of a risk stratification tool for intrapartum fetal compromise in apparently 'low risk' term pregnancies prior to labour.
Study provides mechanistic and clinical evidence that decreased PLGF levels in the placenta after in utero alcohol exposure are associated to brain angiogenesis defects. Measurement of PLGF levels at birth in the placenta or the fetal blood may serve as a predictive marker for subsequent neurodevelopmental outcomes of exposed fetuses.
This effect was reversed by the addition of PlGF neutralising antibody to the conditioned medium.
Results show that both FLT1 (show FLT1 Proteins) and PGF are overexpressed in the circulating tumor cells (CTCs) of patients with breast cancer. Also, a functional interaction of sFlt1 (show FLT1 Proteins) and PGF was found, suggesting that their overexpression in tumor cells inhibits CTCs entering the peripheral blood.
Identify a novel cis (show CISH Proteins)-acting sequence (-369 to -320) at the placental growth factor promoter, which was critical for mediating the basal and DLX3 (show DLX3 Proteins)/GCM1 (show GCM1 Proteins)-dependent PGF promoter activities.
Low PlGF identifies small fetuses with significant underlying placental pathology and is a promising tool for antenatal discrimination of fetal growth retardation from fetuses who are constitutionally-small.
Serum and urinary sFlt-1 and sFlt-1/PLGF ratios in severe preeclampsia patients were significantly higher than those in the mild preeclampsia group, and mild preeclampsia patients were significantly higher than controls. The serum and urinary PLGF levels in severe preeclampsia patients were significantly lower than mild preeclampsia patients, and mild preeclampsia patients had significantly lower PLGF levels than controls
ROS (show ROS1 Proteins) activation of the MAPK (ERK (show MAPK1 Proteins)-1 (show MAPK3 Proteins)/2)/Egr-1 (show EGR1 Proteins) pathway is a main player in the regulatory mechanism for cigarette smoke extract-induced PlGF production. Antioxidants could partly abolish these effects.
Both the TNF-alpha (show TNF Proteins)/IL-10 (show IL10 Proteins) and sFlt-1/PlGF ratios were higher in placental homogenate of early-onset Preeclampsia (PE) than late-onset PE and control groups. The more severe lesions and the imbalance between TNF-alpha (show TNF Proteins)/IL-10 (show IL10 Proteins) and PlGF/sFlt-1 in placentas from early-onset PE allows differentiation of early and late-onset PE and suggests higher placental impairment in early-onset PE
PlGF is abundant in the human endometrium, and secreted into the uterine lumen where it mediates functional changes in cellular adhesion with important roles in implantation
PGF (show PTGFR Proteins) deficiency is associated with impaired cerebral vascular development in mice.
PlGF inhibition attenuates PERK (show EIF2AK3 Proteins) activation, likely by tempering hypoxia in HCC (show FAM126A Proteins) via vessel normalisation. The UPR is able to regulate PlGF expression, suggesting the existence of a feedback mechanism for hypoxia-mediated UPR
Placenta growth factor augments airway hyperresponsiveness via leukotrienes and IL-13 (show IL13 Proteins).
Data indicate that placental growth factor (PlGF) is needed in the spleen to allow the activation of T cells and blood pressure raising.
Placental growth factor promotes differentiation of bone marrow-derived macrophages and enhanced vascular endothelial cell proliferation.
PLGF in LC cells induced macrophage polarization in vivo, and significantly promoted the growth of LC.
PLGF is upregulated in vascular cells in response to fluid shear stress.
Data suggests that PLGF may target islet endothelia to release growth factors activating PI3k signalling in beta cells to increase their proliferation. In Pre-Eclampsia, PLGF reduction impairs these processes resulting in gestational diabetes mellitus.
The neutrophil elastase (show ELANE Proteins)-PlGF-JNK (show MAPK8 Proteins)/PKCdelta (show PKCd Proteins) pathway contributes to the pathogenesis of lung epithelial cell apoptosis and emphysema.
Study reports polymorphisms in the bovine PGF gene significantly associated with the maternal effect on stillbirth and calving ease in animals under selection.
placenta growth factor expression is regulated by both VEGF (show VEGFA Proteins) and hyperglycaemia via VEGFR-2 (show KDR Proteins)
This gene encodes a growth factor found in placenta which is homologous to vascular endothelial growth factor. Alternatively spliced transcripts encoding different isoforms have been found for this gene.
placental growth factor, vascular endothelial growth factor-related protein
, placenta growth factor
, placenta growth factor-like