Browse our AXIN1 Proteins (AXIN1)

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Axin 1 Proteins (AXIN1)
On are 8 Axin 1 (AXIN1) Proteins from 5 different suppliers available. Additionally we are shipping AXIN1 Antibodies (144) and AXIN1 Kits (8) and many more products for this protein. A total of 168 AXIN1 products are currently listed.
AI316800, Axin, AXIN1, AXIN1-RGS, Fu, fused, Kb, Ki, kinky, knobbly, LOC100226467, PPP1R49, wu:fi22e03, wu:fj14c08, wu:fk11b03, xAxin, zgc:109872
list all proteins Gene Name GeneID UniProt
AXIN1 8312 O15169
AXIN1 12005 O35625
AXIN1 79257 O70239

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AXIN1 Proteins (AXIN1) by Origin

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Top referenced AXIN1 Proteins

  1. Human AXIN1 Protein expressed in HEK-293 Cells - ABIN2715088 : Cha, Cho, Lee, Lee, Jeong, Moon, Yun, Yang, Choi, Yoon, Kim, Kim, Kaduwal, Lee, Min, Kim, Han, Choi: Small-molecule binding of the axin RGS domain promotes β-catenin and Ras degradation. in Nature chemical biology 2016 (PubMed)

More Proteins for AXIN1 Interaction Partners

Xenopus laevis Axin 1 (AXIN1) interaction partners

  1. analysis of differential role of Axin RGS (show PITX2 Proteins) domain function in Wnt (show WNT2 Proteins) signaling during anteroposterior patterning and maternal axis formation

  2. APC (show APC Proteins) and Axin are involved in the Wnt (show WNT2 Proteins) pathway

  3. Axin binds directly to the export factor CRM1 (show XPO1 Proteins) in the presence of RanGTP

Human Axin 1 (AXIN1) interaction partners

  1. role in the formation of degradasomes and degradation of beta-catenin (show CTNNB1 Proteins) induced by the TNKSi G007-LK in colorectal cancer cells

  2. VDR (show CYP27B1 Proteins) is important for the maintenance of physiological level of Axin1

  3. RUNX1 (show RUNX1 Proteins) and AXIN1 proteins are strongly correlated in ER(-) tumors as well.

  4. Mutagenesis and binding studies using the bivalent TNKS (show TNKS Proteins) binding domain of Axin1 demonstrate that only certain ankyrin repeat clusters combinations function together. SAXS analysis is consistent with a dynamic ensemble of TNKS (show TNKS Proteins) ankyrin repeat conformations modulated by Axin1 interaction.

  5. LGALS3 (show LGALS3 Proteins) and AXIN1 genes affect tumor sizes and the mucinous component via Wnt (show WNT2 Proteins)/ beta-catenin (show CTNNB1 Proteins) pathway in the pathogenesis of colorectal cancer

  6. The AXIN1 rs1805105 SNP was associated with small tumor size and early tumor stage in hepatocellular carcinoma.

  7. AXIN1 is expressed in meningioma along with APC (show APC Proteins) and E-cadherin (show CDH1 Proteins)

  8. Data show that poly(ADP-ribose) polymerase (PARP (show PARP1 Proteins)) enzyme Tankyrase (TNKS (show TNKS Proteins)) inhibition in colon cancer cells decreases beta-catenin (show CTNNB1 Proteins) signaling at the level of both Axin and APC2.

  9. Cancer point mutations in the scaffold protein (show HOMER1 Proteins) Axin derail Wnt (show WNT2 Proteins) signaling and promote tumor growth in vivo through a gain-of-function mechanism.

  10. The pool of ADP-ribosylated Axin, which is degraded under basal conditions, increases immediately following Wnt (show WNT2 Proteins) stimulation in both Drosophila and human cells.

Mouse (Murine) Axin 1 (AXIN1) interaction partners

  1. Axin-1 is critical for spindle organization and cell cycle progression during meiotic maturation in mouse oocytes.

  2. VDR (show CYP27B1 Proteins) is important for the maintenance of physiological level of Axin1

  3. Axin1 promotes dendritic spine stabilization through Cdc42 (show CDC42 Proteins)-dependent cytoskeletal reorganization.

  4. Axin1 and Axin2 (show AXIN2 Proteins) do not have equivalent functions in satellite cells, but are both involved in repression of Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signalling to maintain proliferation and contribute to controlling timely myogenic differentiation.

  5. Study reports that NRF2 (show NFE2L2 Proteins) participates in the formation of a protein complex with Axin1/GSK-3/beta-TrCP (show BTRC Proteins) that is disrupted by WNT-3A (show WNT3A Proteins), a prototypic canonical WNT (show WNT2 Proteins) ligand, and leads to upregulation of the NRF2 (show NFE2L2 Proteins) transcriptional signature.

  6. Smurf1 (show SMURF1 Proteins)-mediated Lys29-linked nonproteolytic polyubiquitination of axin1 negatively regulates Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling.

  7. This study demonistrated that Axin directs the amplification and differentiation of intermediate progenitors in the developing cerebral cortex in mice.

  8. results suggestg HSV-1 replication enhancement might be mediated by the axin RGS (show PITX2 Proteins) domain.

  9. an asymmetrical distribution pattern for Axin1 transcripts in 2-cell embryos.

  10. Conditional disruption of Axin1 leads to development of liver tumors in mice.

Zebrafish Axin 1 (AXIN1) interaction partners

  1. beta-catenin1 cannot revert the ich (show ACE Proteins) phenotype because it may be under the control of a GSK3beta-independent mechanism that required Axin's RGS (show PITX2 Proteins) domain function.

  2. analysis of differential role of Axin RGS (show PITX2 Proteins) domain function in Wnt (show WNT2 Proteins) signaling during anteroposterior patterning and maternal axis formation

  3. Wnt (show WNT2 Proteins)/Axin/beta-catenin (show CTNNB1 Proteins) pathway has a role in ventral CNS development

  4. Overactivation of Wnt (show WNT2 Proteins)/Axin1/beta-catenin (show CTNNB1 Proteins) signaling during late gastrulation leads to bilateral epithalamic expression of Nodal pathway genes independently of lateral plate mesoderm Nodal signaling.

  5. A dorsalization pathway that is exerted by Axin/JNK (show MAPK8 Proteins) signaling and its inhibitor Aida (show AIDA Proteins) during vertebrate embryogenesis, is defined.

  6. Dab2 (show DAB2 Proteins) stabilizes Axin and attenuates Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling by preventing PP1 (show PPYR1 Proteins) from binding Axin

AXIN1 Protein Profile

Protein Summary

This gene encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain. The encoded protein interacts with adenomatosis polyposis coli, catenin beta-1, glycogen synthase kinase 3 beta, protein phosphate 2, and itself. This protein functions as a negative regulator of the wingless-type MMTV integration site family, member 1 (WNT) signaling pathway and can induce apoptosis. The crystal structure of a portion of this protein, alone and in a complex with other proteins, has been resolved. Mutations in this gene have been associated with hepatocellular carcinoma, hepatoblastomas, ovarian endometriod adenocarcinomas, and medullablastomas. Two transcript variants encoding distinct isoforms have been identified for this gene.

Alternative names and synonyms associated with AXIN1

  • axin 1 (AXIN1)
  • axin 1 (axin1)
  • axin 1 (LOC100226467)
  • axin (axin1)
  • axin 1 (Axin1)
  • AI316800 protein
  • Axin protein
  • AXIN1 protein
  • AXIN1-RGS protein
  • Fu protein
  • fused protein
  • Kb protein
  • Ki protein
  • kinky protein
  • knobbly protein
  • LOC100226467 protein
  • PPP1R49 protein
  • wu:fi22e03 protein
  • wu:fj14c08 protein
  • wu:fk11b03 protein
  • xAxin protein
  • zgc:109872 protein

Protein level used designations for Axin 1 Proteins (AXIN1)

axin 1 , axin 1, isoform 1 , axin-1-like , axin-1 , xAxin , axis inhibition protein 1 , axis inhibitor 1 , fused, mouse, homolog of , protein phosphatase 1, regulatory subunit 49 , protein Fused , GSK-3beta interacting protein rAxin , rAxin , masterblind , mbl

453789 Pan troglodytes
734298 Xenopus laevis
100137557 Papio anubis
100226467 Taeniopygia guttata
100392475 Callithrix jacchus
100424087 Macaca mulatta
398097 Xenopus laevis
100065116 Equus caballus
8312 Homo sapiens
490099 Canis lupus familiaris
504357 Bos taurus
12005 Mus musculus
79257 Rattus norvegicus
100718536 Cavia porcellus
395786 Gallus gallus
57931 Danio rerio
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