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we identify Casein Kinase I alpha (CK1alpha) as an additional negative-regulator of Cap-H2. CK1a-depletion stabilizes Cap-H2 protein and results in an accumulation of Cap-H2 on chromosomes.
Expected genes in the Scar-Arp2 (show ACTR2 ELISA Kits)/3 actin (show ACTB ELISA Kits) nucleation pathway were identified as well as casein kinase I, which had a similar morphological RNAi signature.
CKI(Casein kinase I) functions as a negative regulator of Arm protein, by phosphorylating it on Ser (show SIGLEC1 ELISA Kits) and Thr (show TRH ELISA Kits) residues in the N-terminus and targeting it for degradation.
2 proteins reported to function in Wingless(Wg) signaling identified as Hh pathway components: Dally-like protein required for Hh signal reception, and casein kinase 1alpha, a candidate tumor suppressor that regulates activities of both Hh and Wg pathways
expression of doubletime in Drosophila S2 cells produced a CKI-7-sensitive kinase activity which was reduced by both the dbt(S) and dbt(L) mutations of circadian rhythm
doubletime and CKII (show CSNK2A1 ELISA Kits) kinases collaborate to potentiate Drosophila PER transcriptional repressor activity
Several CKI isoforms including CKIalpha and Gish/CKIgamma can phosphorylate the Wg coreceptor Arrow (Arr), which may account, at least in part, for their positive roles in the Wg pathway.
Mutation of ck1alpha or -epsilon or sgg/gsk3beta (show GSK3b ELISA Kits) in wing imaginal discs results in the accumulation of dMyc protein, suggesting a physiological role for these kinases in vivo.
Disruption of CK1alpha function in myeloma cells resulted in decreased Mdm2 (show MDM2 ELISA Kits), increased p53 (show TP53 ELISA Kits) and p21 (show CDKN1A ELISA Kits) and reduced expression of beta-catenin (show CTNNB1 ELISA Kits) and AKT (show AKT1 ELISA Kits).
CK1delta enhances EPO (show EPO ELISA Kits) secretion from liver cancer cells under hypoxia by modifying HIF-2alpha (show EPAS1 ELISA Kits) and promoting its nuclear accumulation.
CKIalpha-mediated NS5A S235 phosphorylation is critical for HCV replication. CaMKII (show CAMK2G ELISA Kits) gamma and delta may have negative roles in the HCV life cycle.
Case Report: post-zygotic mosaicism of KRT/1o mutations in epidermolytic Ichthyosis (show LBR ELISA Kits).
KRT1 played an important role of maintaining epithelial barrier and its down-regulation in intestinal tissue was correlated with the progression of inflammatory bowel disease.
Report genetic/clinical spectrum of KRT1 mutations in keratinopathic ichthyosis (show LBR ELISA Kits).
Interactome analyses revealed that the Jade-1S mutant unable to be phosphorylated by CK1alpha has an increased binding affinity to proteins involved in chromatin remodelling, histone deacetylation, transcriptional repression, and ribosome biogenesis.
demonstrated the presence of a genetic cutaneous mosaicism. Both patients carry the KRT1 pI479T substitution, but in the palmoplantar areas of one of them, only the mutated allele is expressed (hemizygous). This leads to highlight a new type of cutaneous mosaic, the palmoplantar mosaicism
study focuses on, how the structural dynamics and conformational changes of two CK1 isoforms are synchronized in carcinogenic pathway
NIFK (show MKI67IP ELISA Kits) is required for lung cancer progression via the RUNX1 (show RUNX1 ELISA Kits)-dependent CK1alpha repression, which activates TCF4 (show TCF4 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits) signaling in metastasis and the Ki-67 (show MKI67 ELISA Kits)-dependent regulation in cell proliferation.
Phosphorylation of LRRK2 (show LRRK2 ELISA Kits) by casein kinase 1alpha regulates trans-Golgi clustering via differential interaction with ARHGEF7 (show ARHGEF7 ELISA Kits).
Phosphorylation of FADD (show FADD ELISA Kits) by the kinase CK1alpha promotes KRASG12D-induced lung cancer.
Csnk1a1 knockdown results in decreased Rps6 (show RPS6 ELISA Kits) phosphorylation, increased p53 (show TP53 ELISA Kits) activity, and myeloid differentiation.
study for the first time demonstrates that CK1alpha is required for chromosome alignment and segregation during oocyte meiotic maturation and early embryo development
Silencing or deleting the p53 (show TP53 ELISA Kits) gene demonstrated that genotoxic stress elicited Wnt (show WNT2 ELISA Kits) signaling in a p53 (show TP53 ELISA Kits)-independent manner. Instead, this response occurred through reduced abundance of Csnk1a1 (CK1alpha), a kinase that inhibits beta-catenin (show CTNNB1 ELISA Kits).
maintenance of intestinal homeostasis in CKIalpha-deficient gut (show GUSB ELISA Kits) requires p53 (show TP53 ELISA Kits)-mediated growth control, because the combined ablation of Csnk1a1 and either p53 (show TP53 ELISA Kits) or its target gene p21 triggered high-grade dysplasia with extensive proliferation
Casein kinase I (show CSNK1D ELISA Kits) and casein kinase II (show CSNK2A1 ELISA Kits) differentially regulate axin (show AXIN1 ELISA Kits) function
CK1alpha-mediated phosphorylation modulates the mRNA binding ability of hnRNP-C
CK1 regulates fast synaptic transmission by glutamate (show GRIN1 ELISA Kits) in brain. Activation of CK1 decreases NMDA receptor activity in the striatum via activation by this kinase of protein phosphatase 1 (show PPP1CB ELISA Kits) &/or 2A & increased dephosphorylation of NMDA receptors.
Here, we report that in response to factors that promote cell motility, the Rap guanine exchange factor RAPGEF2 is rapidly phosphorylated by I-kappa-B-kinase-beta and casein kinase-1alpha and consequently degraded by the proteasome.
The phosphorylation of p53 (show TP53 ELISA Kits) by CK1 is an isoform-specific reaction to the K(221)RQK(224) loop.
data provide a molecular insight into the structural features that underlie the site specificity of CK1a
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the spinous and granular layers of the epidermis with family member KRT10 and mutations in these genes have been associated with bullous congenital ichthyosiform erythroderma. The type II cytokeratins are clustered in a region of chromosome 12q12-q13.
, caesin kinase I alpha
, casein kinase 1
, casein kinase 1a
, casein kinase 1alpha
, casein kinase I
, casein kinase ialpha
, casein kinase I isoform alpha
, clock regulator kinase
, down-regulated in lung cancer
, casein kinase I-alpha
, casein kinase I alpha LS
, CK II alpha
, casein kinase 2, alpha subunit
, casein kinase II subunit alpha
, casein kinase 1 alpha
, protein kinase CK1 (casein kinase 1) isoform alpha
, 67 kDa cytokeratin
, cytokeratin 1
, epidermolytic hyperkeratosis 1
, hair alpha protein
, keratin, type II cytoskeletal 1
, type-II keratin Kb1
, epithelial keratin 1
, epithelial keratin-1
, keratin 1 (epidermolytic hyperkeratosis)