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Human CTNNB1 Protein expressed in Baculovirus infected Insect Cells - ABIN2004177
Hülsken, Birchmeier, Behrens: E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton. in The Journal of cell biology 1995
Show all 6 references for 2004177
Mouse (Murine) CTNNB1 Protein expressed in Baculovirus infected Insect Cells - ABIN2008021
Butz, Kemler: Distinct cadherin-catenin complexes in Ca(2+)-dependent cell-cell adhesion. in FEBS letters 1995
Show all 5 references for 2008021
Human CTNNB1 Protein expressed in Wheat germ - ABIN1350670
Bian, Bai, Chapin, Le Moellic, Dong, Caplan, Sigworth, Navaratnam: Interactions between ?-catenin and the HSlo potassium channel regulates HSlo surface expression. in PLoS ONE 2011
temporal expression of CTNNB1 mRNA during dermal wound repair in the horse
These results support the notion that pharmacological modulation of beta-catenin can be used to treat pseudarthrosis in patients with neurofibromatosis type 1 (show NF1 Proteins).
we revealed miR (show MLXIP Proteins)-375-3p negatively regulated osteogenesis by targeting LRP5 (show LRP5 Proteins) and beta-catenin
ARX positively regulates Wnt (show WNT2 Proteins)/ beta-catenin signaling and the C-terminal domain of ARX interacts with the armadillo (show PKP1 Proteins) repeats in beta-catenin to promote Wnt (show WNT2 Proteins)/beta-catenin signaling. In addition, we found BCL9 (show BCL9 Proteins) and P300 (show NOTCH1 Proteins) also interact with ARX to modulate Wnt (show WNT2 Proteins)/beta-catenin signaling.
our results are consistent with an epithelial proliferative growth mechanism linking CTNNB1-driven Ccnd1 (show CCND1 Proteins) transcription and estrogen-mediated CCND1 (show CCND1 Proteins) protein stabilization.
Rbm46 regulates mouse embryonic stem cell differentiation through down-regulation of beta-Catenin.Rbm46 regulates mouse embryonic stem cell differentiation by targeting beta-Catenin mRNA for degradation.
Beta-catenin may promote bacterial killing via suppression of P. aeruginosa-induced macrophage autophagy.
Data suggest that PKCe (show PRKCE Proteins) positively regulates beta-catenin expression and stabilization in a glycogen synthase kinase 3beta-independent manner; beta-catenin exhibits a perinuclear localization pattern in podocytes; however, beta-catenin is predominantly localized to nucleus in podocytes from PKCe (show PRKCE Proteins) knockout mice. (PKCe (show PRKCE Proteins) = protein kinase C epsilon (show PRKCE Proteins))
Leukocyte beta-catenin expression is disturbed in systemic lupus erythematosus in patients and lupus-prone mice.
We have identified cooperation of hMet and beta-catenin activation in a subset of hepatocellular cancer patients and modeled this human disease in mice with a significant transcriptomic intersection; this model will provide novel insight into the biology of this tumor and allow us to evaluate novel therapies as a step toward precision medicine
GLP-1 (show GCG Proteins) promoted adipogenesis through the modulation of the Wnt4 (show WNT4 Proteins)/beta-catenin signaling pathway
Mechanistically, Hif-3alpha2 binds to beta-catenin and destabilizes the nuclear beta-catenin complex.
Nuclear beta-catenin is an indication of an activated Wnt (show WNT2 Proteins) pathway, therefore suggesting a possible role for Wnt (show WNT2 Proteins) signalling during zebrafish tooth development and replacement.
Findings suggest that microRNA 19b (miR (show MYLIP Proteins)-19b) regulates laterality development and heart looping in embryos by targeting beta-catenin ctnnb1.
Custos binds to beta-catenin in a Wnt (show WNT2 Proteins) responsive manner without affecting its stability, but rather modulates the cytoplasmic to nuclear translocation of beta-catenin.
The role of the beta-catenin mechanosensitive pathway in mesoderm identity has been conserved over the large evolutionary distance separating zebrafish and Drosophila.
The Wnt (show WNT2 Proteins)/beta-catenin signaling pathway establishes neuroanatomical asymmetries and their laterality. (Review)
This study demonstrated that beta-catenin/Wnt (show WNT2 Proteins) signaling is initially required to activate cell-cycle re-entry in Muller glia following injury and that Wnt (show WNT2 Proteins) signaling subsequently controls the fate of the progeny of those cell divisions.
A novel role for Eaf1 (show EAF1 Proteins) and Eaf2 (show EAF2 Proteins) in inhibiting canonical Wnt (show WNT2 Proteins)/beta-catenin signaling, which might form the mechanistic basis for Eaf1 (show EAF1 Proteins) and Eaf2 (show EAF2 Proteins) tumor suppressor activity.
Ccr7 (show CCR7 Proteins) functions during axis formation as a GPCR to inhibit beta-catenin, likely by promoting Ca(2 (show CA2 Proteins)+) transients throughout the blastula.
ctnnb1 and ctnnb2 regulate multiple processes of laterality development in zebrafish embryos through similar and distinct mechanisms.
Together, these results indicate that capsaicin inhibits the patterning of the dorso-ventral and anterior-posterior body axes of embryo by repressing PP2A (show PPP2R2B Proteins) and thereby down-regulating the Wnt (show WNT2 Proteins)/beta-catenin signaling.
maternal Wnt (show WNT2 Proteins)/STOP signaling, but not beta-catenin signaling, has a role in cleavage after fertilization and cell cycle progression
Wnt (show WNT2 Proteins) signalling can benefit from nucleo-cytoplasmic shuttling of APC (show APC Proteins), Axin (show AXIN1 Proteins) and GSK3, although they are in general beta-catenin antagonising proteins.
Phosphoinositide 3-kinase and Rac (show AKT1 Proteins) polarization depend specifically on the N-cadherin (show CDH2 Proteins)-p120 catenin (show CTNND1 Proteins) complex, whereas myosin II light chain and actin filament polarization depend on the N-cadherin (show CDH2 Proteins)-beta-catenin complex.
HERG (show KCNH2 Proteins) channel activity is stimulated by beta-catenin
Zic3 (show ZIC3 Proteins) can suppress Wnt (show WNT2 Proteins)/beta-catenin signaling and control development of the notochord and Spemann's organizer.
Notch initially destabilises beta-catenin in a process that does not depend on its phosphorylation by GSK3
The tyrosine kinase receptor (show KDR Proteins), PTK7 (show PTK7 Proteins), is implicated in beta-catenin-dependent developmental processes.
Kazrin (show KAZ Proteins) interacts with ARVCF (show ARVCF Proteins)-catenin, spectrin and p190B RhoGAP (show ARHGAP1 Proteins), and modulates RhoA (show RHOA Proteins) activity.
TSPAN2 (show TSPAN2 Proteins) may promote apoptosis of RNAKT-15 cells by regulating the JNK (show MAPK8 Proteins)/beta-catenin pathway in response to high glucose concentrations. Targeting TSPAN2 (show TSPAN2 Proteins) could be a potential therapeutic strategy to treat glucose toxicity-induced beta-cell failure.
Case Reports/Review: CTNNB1 point-mutations/deletion mutations in ovarian microcystic stromal tumors.
UBQLN4 (show UBQLN4 Proteins), APP (show APP Proteins), CTNNB1, SHBG (show SHBG Proteins), and COL1A1 (show COL1A1 Proteins) might be involved in the development of nonalcoholic fatty liver disease, and are proposed as the potential markers for predicting the development of this condition
Our findings suggest that Pyk2 (show PTK2B Proteins) plays an important role in the coordination of stabilization of beta-catenin in the crosstalk between Wnt (show WNT2 Proteins)/beta-catenin and Wnt (show WNT2 Proteins)/Ca(2 (show CA2 Proteins)+) signaling pathways upon Wnt3a (show WNT3A Proteins) stimulation in differentiating hNPCs.
Data show that in colorectal cancer SerpinB3 (show SERPINB3 Proteins), COX-2 and beta-Catenin are positively correlated and associated with more advanced tumor stage.
DDX17 (show DDX17 Proteins) contributes to acquired gefitinib resistance through exportin (show XPO1 Proteins)/importin (show KPNA4 Proteins)-dependent cytoplasmic shuttling and activation of beta-catenin in non-small lung cancer cells.
An extended immunohistochemical panel that includes beta-catenin and SOX10 (show SOX10 Proteins) helps to support the diagnosis of biphenotypic sinonasal sarcoma without the need for gene rearrangement studies.
All substances, nilotinib, dasatinib, erlotinib and gefitinib have a significant impact on beta-catenin and E-cadherin (show CDH1 Proteins) expression in both HPV16-positive and HPV16-negative cells in vitro. Hence, alterations of beta-catenin and E-cadherin (show CDH1 Proteins) could provide novel insights for future targeted therapies of head and neck SCC (show CYP11A1 Proteins)
Low CTNNB1 expression is associated with Metastasis in Colorectal Cancer.
NF-kappaB (show NFKB1 Proteins) and beta-catenin signaling by gain-of-function mutations in CARMA1 (show CARD11 Proteins) augments WNT (show WNT2 Proteins) stimulation and is required for regulating the expression of distinct NF-kappaB (show NFKB1 Proteins) target genes to trigger cell-intrinsic and extrinsic processes that promote DLBCL lymphomagenesis
Results highlight a potential role for the beta-catenin/Wnt (show WNT2 Proteins) and Notch (show NOTCH1 Proteins) signalling pathways during the infection of crypt cells by L. intracellularis.
Flutamide exposure led to decreased beta-catenin in corpus luteum of mid/late pregnancy.
beta-catenin signaling is involved in formation of contractile membranes by dedifferentiated retinal pigment epithelium cells.
Wnt3a (show WNT3A Proteins) produced a significant increase in heart valve interstitial cell number at day 4 and in the percentage of BrdU-positive nuclei at 24 h. The increase in proliferation was abolished by beta-catenin siRNA.
beta-catenin controls myocardin-related transcription factor-dependent transcription and emerges as a critical regulator of an array of cytoskeletal genes
beta-Catenin plays a critical role in mediating TGF-beta1 (show TGFB1 Proteins)-induced myofibroblast differentiation in aortic valve interstitial cells.
scratching-induced injury and repair of bronchial epithelial cells may involve inhibition of Glycogen synthase kinase 3beta activity which can lead to activation of the downstream signaling through beta-catenin
Data show that Wnt3a (show WNT3A Proteins) can inhibit the adipogenic differentiation of porcine AMSCs, and suggest that Wnt (show WNT2 Proteins)/beta-catenin signaling inhibits adipogenic differentiation potential and alters the cell fate from adipocytes to osteoblasts.
TNF-alpha (show TNF Proteins) inhibits adipogenesis through stabilization of beta-catenin protein in porcine preadipocytes.
Bovine herpesvirus 1 transiently increased beta-catenin protein levels in bovine kidney cells, but not in rabbit skin cells.
These results demonstrate that activation of AKT (show AKT1 Proteins) is required for gonadotropin regulation of CTNNB1 accumulation and subsequent ovarian E2 production.
beta-catenin, a transcription factor activated by the canonical Wnt signaling pathway, was frequently detected in bovine herpesvirus 1 ORF2-positive trigeminal ganglionic neurons of latently infected, but not mock-infected, calves.
These data demonstrate for the first time that FSH (show BRD2 Proteins) regulates CTNNB1 protein and WNT2 (show WNT2 Proteins) mRNA expressions in bovine granulosa cells, suggesting a potential role of canonical WNT (show WNT2 Proteins) signaling in ovarian steroidogenesis and follicular growth of cattle.
These data provide evidence that testosterone increases cellular beta-catenin content which promotes the expression of beta-catenin-targeted genes and myogenesis in the muscle-derived stem cells of cattle.
that beta-catenin is a plasma membrane-associated protein (show PDZK1IP1 Proteins) in airway smooth muscle that regulates active tension development, presumably by stabilizing cell-cell contacts and thereby supporting force transmission between neighboring cells.
This study demonstrated a relationship between the timing of the development of in vitro-produced bovine embryos and the distribution and localization of the junction protein beta-catenin.
TGF-beta3 (show TGFB3 Proteins) induces the chondrogenic differentiation of pericytes by inducing Wnt (show WNT2 Proteins)/beta-catenin signaling and T-cell factor-induced gene transcription.
cAMP/PKA regulation of GSK3beta/beta-catenin signaling contributes to the increase in progesterone production in corpus luteum.
Palmatin effect on osteoarthritis is likely mediated via the Wnt (show WNT2 Proteins)/beta-catenin and Hedgehog (show SHH Proteins) signaling
These results collectively showed that 2-Deoxy-D-glucose regulates dedifferentiation via beta-catenin pathway in rabbit articular chondrocytes.
The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for this gene.
catenin beta 1 subunit
, catenin beta-1
, beta catenin 1
, catenin (cadherin-associated protein), beta 1, 88kDa
, catenin beta-1-like
, catenin (cadherin associated protein), beta 1, 88kDa
, catenin beta
, beta catenin