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Human CTNNB1 Protein expressed in Baculovirus infected Insect Cells - ABIN2004177
Hülsken, Birchmeier, Behrens: E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton. in The Journal of cell biology 1995
Show all 6 references for ABIN2004177
Mouse (Murine) CTNNB1 Protein expressed in Baculovirus infected Insect Cells - ABIN2008021
Butz, Kemler: Distinct cadherin-catenin complexes in Ca(2+)-dependent cell-cell adhesion. in FEBS letters 1995
Show all 5 references for ABIN2008021
Human CTNNB1 Protein expressed in Wheat germ - ABIN1350670
Bian, Bai, Chapin, Le Moellic, Dong, Caplan, Sigworth, Navaratnam: Interactions between ?-catenin and the HSlo potassium channel regulates HSlo surface expression. in PLoS ONE 2011
temporal expression of CTNNB1 mRNA during dermal wound repair in the horse
Wnt (show WNT2 Proteins)/beta-catenin signaling pathway abnormalities possibly play an important role in the development of cognitive deficits among mice exposed to chronic intermittent hypoxia.
Our findings highlight the critical roles of SIK1 and its targets in the regulation of HCC (show FAM126A Proteins) development and provides potential new candidates for HCC (show FAM126A Proteins) therapy.
PAX5 (show PAX5 Proteins) was found to be an epigenetically inactivated tumor suppressor that inhibited non-small-cell lung proliferation and metastasis, through down-regulating the beta-catenin pathway and up-regulating GADD45G (show GADD45G Proteins) expression.
Data show athat beta-catenin can be activated by bone morphogenetic protein 9 (BMP9 (show GDF2 Proteins)) and the activation of beta-catenin plays an important role in the differentiation of C3H10T1/2 cells into cardiomyocyte-like cells induced by BMP9 (show GDF2 Proteins).
STAT3 (show STAT3 Proteins)/Arid1b/beta-catenin pathway is driving neurofibroma initiation.
stabilization of b-catenin in cholangiocyte precursors perturbed duct development and cholangiocyte differentiation. We conclude that b-catenin is dispensable for biliary development but that its activity must be kept within tight limits.
Our study contributes to the understanding of the role of HIF1alpha (show HIF1A Proteins) in OA and highlights the HIF1alpha (show HIF1A Proteins)-beta-catenin interaction, thus providing new insights into the impact of hypoxia in articular cartilage.
To test the tumorigenic potential of different cell types in the developing kidney, we used kidney progenitor-specific Cre recombinase alleles to introduce Wt1 and Ctnnb1 mutations, two alterations observed in Wilms tumor, into embryonic mouse kidney, with and without biallelic Igf2 expression, another alteration that is observed in a majority of tumors
These data highlight the ability of PTH (show PTH Proteins) to phosphorylate beta-catenin directly via PKA.
a conserved pro-fibrotic signal cascade might underlie beta-catenin-mediated bone marrow fibrosis.
Mechanistically, Hif-3alpha2 binds to beta-catenin and destabilizes the nuclear beta-catenin complex.
Nuclear beta-catenin is an indication of an activated Wnt (show WNT2 Proteins) pathway, therefore suggesting a possible role for Wnt (show WNT2 Proteins) signalling during zebrafish tooth development and replacement.
Findings suggest that microRNA 19b (miR (show MYLIP Proteins)-19b) regulates laterality development and heart looping in embryos by targeting beta-catenin ctnnb1.
Custos binds to beta-catenin in a Wnt (show WNT2 Proteins) responsive manner without affecting its stability, but rather modulates the cytoplasmic to nuclear translocation of beta-catenin.
The role of the beta-catenin mechanosensitive pathway in mesoderm identity has been conserved over the large evolutionary distance separating zebrafish and Drosophila.
The Wnt (show WNT2 Proteins)/beta-catenin signaling pathway establishes neuroanatomical asymmetries and their laterality. (Review)
This study demonstrated that beta-catenin/Wnt (show WNT2 Proteins) signaling is initially required to activate cell-cycle re-entry in Muller glia following injury and that Wnt (show WNT2 Proteins) signaling subsequently controls the fate of the progeny of those cell divisions.
A novel role for Eaf1 (show EAF1 Proteins) and Eaf2 (show EAF2 Proteins) in inhibiting canonical Wnt (show WNT2 Proteins)/beta-catenin signaling, which might form the mechanistic basis for Eaf1 (show EAF1 Proteins) and Eaf2 (show EAF2 Proteins) tumor suppressor activity.
Ccr7 (show CCR7 Proteins) functions during axis formation as a GPCR to inhibit beta-catenin, likely by promoting Ca(2 (show CA2 Proteins)+) transients throughout the blastula.
ctnnb1 and ctnnb2 regulate multiple processes of laterality development in zebrafish embryos through similar and distinct mechanisms.
maternal Wnt (show WNT2 Proteins)/STOP signaling, but not beta-catenin signaling, has a role in cleavage after fertilization and cell cycle progression
Wnt (show WNT2 Proteins) signalling can benefit from nucleo-cytoplasmic shuttling of APC (show APC Proteins), Axin (show AXIN1 Proteins) and GSK3, although they are in general beta-catenin antagonising proteins.
Phosphoinositide 3-kinase and Rac (show AKT1 Proteins) polarization depend specifically on the N-cadherin (show CDH2 Proteins)-p120 catenin (show CTNND1 Proteins) complex, whereas myosin II light chain and actin filament polarization depend on the N-cadherin (show CDH2 Proteins)-beta-catenin complex.
HERG (show KCNH2 Proteins) channel activity is stimulated by beta-catenin
Zic3 (show ZIC3 Proteins) can suppress Wnt (show WNT2 Proteins)/beta-catenin signaling and control development of the notochord and Spemann's organizer.
Notch initially destabilises beta-catenin in a process that does not depend on its phosphorylation by GSK3
The tyrosine kinase receptor (show KDR Proteins), PTK7 (show PTK7 Proteins), is implicated in beta-catenin-dependent developmental processes.
Kazrin (show KAZ Proteins) interacts with ARVCF (show ARVCF Proteins)-catenin, spectrin and p190B RhoGAP (show ARHGAP1 Proteins), and modulates RhoA (show RHOA Proteins) activity.
Activated Xenopus CTNNB1 regulates embryonic limb development via FGF signaling
Results are the first to describe the presence of Wnt (show WNT2 Proteins) signaling pathway abnormalities, manifested by nuclear beta-catenin, in a subset, as well as the lack of BRAF (show BRAF Proteins)(V600E) mutation in gliosarcoma.
Reduced expression of Wif-1 (show WIF1 Proteins) and increased expression of beta-catenin may be involved in the pathogenesis of childhood acute lymphoblastic leukemia (ALL).
A considerable number of TNBC co-expresses E-cadherin (show CDH1 Proteins) and P-cadherin, while membranous localization of beta-catenin may predict patient outcome in an EGFR (show EGFR Proteins)-dependent manner. This novel interaction seems worthy for validating with regards to its biological and clinical relevance
our mutation analysis detected already known mutations as well as, to the best of our knowledge, mutations and an interstitial deletion of CTNNB1 not described in JAs (show TAP2 Proteins) before. Additionally, a so far unknown transcribed Axin2 (show AXIN2 Proteins) splice variant was found, but no further Axin2 (show AXIN2 Proteins) mutations
this is the first demonstration of a role for the leupaxin (show LPXN Proteins) in the regulation of hepatocellular carcinoma progression, at least in part, by enhancing beta-catenin transcription activity.
an activating mutation in CTNNB1 (S33F) was found in one colorectal tumor sample and immunohistochemical staining showed the accumulation of beta-catenin protein both in cytoplasm and in the nuclei of cancer cells as compared to normal tissue
Reduced expression of beta-catenin expression in cell membrane is associated with esophageal carcinoma.
Gene alterations in TERT (show TERT Proteins) promoter, TP53 (show TP53 Proteins), CTNNB1, and hepatitis B virus integration were closely associated with hepatocellular carcinoma development
Taken together, these data suggest that SOX1 (show SOX1 Proteins) can function as a tumor suppressor partly by interfering with Wnt (show WNT2 Proteins)/beta-catenin signaling in breast cancer.
beta-Catenin seems to be involved in the regulation of gelsolin (show GSN Proteins) expression, which in turn affects the migratory ability of colonic cancer cells
Flutamide exposure led to decreased beta-catenin in corpus luteum of mid/late pregnancy.
beta-catenin signaling is involved in formation of contractile membranes by dedifferentiated retinal pigment epithelium cells.
Wnt3a (show WNT3A Proteins) produced a significant increase in heart valve interstitial cell number at day 4 and in the percentage of BrdU-positive nuclei at 24 h. The increase in proliferation was abolished by beta-catenin siRNA.
beta-catenin controls myocardin-related transcription factor-dependent transcription and emerges as a critical regulator of an array of cytoskeletal genes
beta-Catenin plays a critical role in mediating TGF-beta1 (show TGFB1 Proteins)-induced myofibroblast differentiation in aortic valve interstitial cells.
scratching-induced injury and repair of bronchial epithelial cells may involve inhibition of Glycogen synthase kinase 3beta activity which can lead to activation of the downstream signaling through beta-catenin
Data show that Wnt3a (show WNT3A Proteins) can inhibit the adipogenic differentiation of porcine AMSCs, and suggest that Wnt (show WNT2 Proteins)/beta-catenin signaling inhibits adipogenic differentiation potential and alters the cell fate from adipocytes to osteoblasts.
TNF-alpha (show TNF Proteins) inhibits adipogenesis through stabilization of beta-catenin protein in porcine preadipocytes.
These results demonstrate that activation of AKT (show AKT1 Proteins) is required for gonadotropin regulation of CTNNB1 accumulation and subsequent ovarian E2 production.
beta-catenin, a transcription factor activated by the canonical Wnt signaling pathway, was frequently detected in bovine herpesvirus 1 ORF2-positive trigeminal ganglionic neurons of latently infected, but not mock-infected, calves.
These data demonstrate for the first time that FSH (show BRD2 Proteins) regulates CTNNB1 protein and WNT2 (show WNT2 Proteins) mRNA expressions in bovine granulosa cells, suggesting a potential role of canonical WNT (show WNT2 Proteins) signaling in ovarian steroidogenesis and follicular growth of cattle.
These data provide evidence that testosterone increases cellular beta-catenin content which promotes the expression of beta-catenin-targeted genes and myogenesis in the muscle-derived stem cells of cattle.
that beta-catenin is a plasma membrane-associated protein (show PDZK1IP1 Proteins) in airway smooth muscle that regulates active tension development, presumably by stabilizing cell-cell contacts and thereby supporting force transmission between neighboring cells.
This study demonstrated a relationship between the timing of the development of in vitro-produced bovine embryos and the distribution and localization of the junction protein beta-catenin.
TGF-beta3 (show TGFB3 Proteins) induces the chondrogenic differentiation of pericytes by inducing Wnt (show WNT2 Proteins)/beta-catenin signaling and T-cell factor-induced gene transcription.
cAMP/PKA regulation of GSK3beta/beta-catenin signaling contributes to the increase in progesterone production in corpus luteum.
Palmatin effect on osteoarthritis is likely mediated via the Wnt (show WNT2 Proteins)/beta-catenin and Hedgehog (show SHH Proteins) signaling
These results collectively showed that 2-Deoxy-D-glucose regulates dedifferentiation via beta-catenin pathway in rabbit articular chondrocytes.
The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for this gene.
catenin beta 1 subunit
, catenin beta-1
, beta catenin 1
, catenin (cadherin-associated protein), beta 1, 88kDa
, catenin beta-1-like
, catenin (cadherin associated protein), beta 1, 88kDa
, catenin beta
, beta catenin