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Inturned links NPHP4 to Daam1 to control the subapical actin network in multiciliated cells
Daams are expressed in tissues known to require Wnts, so effectors of Wnt (show WNT2 Proteins) signaling during vertebrate development.
Kif26b, together with Dvl3 (show DVL3 Proteins)/Daam1, initiates cell polarity through the control of planar cell polarity-signaling pathway-dependent activation in endothelial cells.
Daam1 plays a dual role in the phagocytic uptake of borreliae.
A developmentally restricted function of miR (show MLXIP Proteins)-490 and its putative DAAM1 target are associated with exaggerated megakaryocytopoiesis and/or proplatelet formation.
Wnt5a (show WNT5A Proteins) promotes breast cancer cell migration via Dvl2 (show DVL2 Proteins)/Daam1/RhoA (show RHOA Proteins).
DAAM1 is a formin (show FMN1 Proteins) required for centrosome re-orientation during cell migration.
Fli-I promotes the GTP-bound active Rho-mediated relief of the autoinhibition of Daam1 and mDia1. Thus, Fli-I is a novel positive regulator of Rho-induced linear actin assembly mediated by DRFs.
DAAM1 regulates endothelial cell growth through MT stabilization in a cell type-selective manner
DAAM1 was shown to bind to the SH3 domain of CIP4 in vivo.
Results report that Profilin1 (show PFN1 Proteins) is an effector downstream of Daam1 required for cytoskeletal changes during gastrulation.
The DAAM1 FH2 domain structure, determined at 2.25 A resolution, and DAAM1 actin binding activity
Daam1 knockout mice that were also homozygous for Daam2 had stronger noncompaction cardiomyopathy, severely reduced cardiac function, disrupted sarcomere structure, and increased myocardial proliferation.
Fascin and Daam1 coimmunoprecipitated from cell extracts, and silencing of fascin led to a striking loss of Daam1 localization to filopodial shafts. Purified fascin bound directly to Daam1; fascin recruited Daam1 to and stabilized Daam1 on actin bundles.
Daam1 is important for regulating filamentous actin assembly and organization, and consequently for cytoskeletal function in cardiomyocytes, which contributes to proper heart morphogenesis.
a carboxyl-terminal binding partner, Dvl (show DVL1 Proteins), has a role in activation of Daam1
Results indicate that Daam1a plays a key role in asymmetric habenular morphogenesis mediating the growth of dendritic and axonal processes in dorsal habenular neurons.
Pronephric tubulogenesis requires the Daam1/WGEF (show ARHGEF19 Proteins)/Rho PCP (show PRCP Proteins) pathway.
Daam1 is a dynamic coordinator of endocytosis and cytoskeletal remodeling underlying the convergent extension movement of notochord cells.
Cell motility, adhesion, cytokinesis, and other functions of the cell cortex are mediated by reorganization of the actin cytoskeleton and several formin homology (FH) proteins have been associated with these processes. The protein encoded by this gene contains two FH domains and belongs to a novel FH protein subfamily implicated in cell polarity. A key regulator of cytoskeletal architecture, the small GTPase Rho, is activated during development by Wnt/Fz signaling to control cell polarity and movement. The protein encoded by this gene is thought to function as a scaffolding protein for the Wnt-induced assembly of a disheveled (Dvl)-Rho complex. This protein also promotes the nucleation and elongation of new actin filaments and regulates cell growth through the stabilization of microtubules. Alternative splicing results in multiple transcript variants encoding distinct proteins.
dishevelled associated activator of morphogenesis 1
, disheveled-associated activator of morphogenesis 1-like
, disheveled-associated activator of morphogenesis 1
, dishevelled-associated activator of morphogenesis 1