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the dynamic state of Dkk4 itself and its interaction with Lrp6 (show LRP6 ELISA Kits) modulates Wnt (show WNT2 ELISA Kits) function during Meibomian gland development, with a novel limitation of Dkk4 action by proteolytic cleavage.
sweat gland development shows a relay of regulatory steps initiated by Wnt (show WNT2 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits) - itself modulated by Dkk4 - with subsequent participation of Eda (show EDA ELISA Kits) and Shh (show SHH ELISA Kits) pathways.
These results showed that Dkk4 functions as an inhibitor of osteoblastogenesis through Wnt (show WNT2 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits) signaling, providing new insights into the relationship between Wnt (show WNT2 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits) signaling and Dkk4 in bone formation.
It would appear that deregulation of the WNT (show WNT2 ELISA Kits) pathway by overexpression of DKK4 may further impair WNT (show WNT2 ELISA Kits) signaling and lead to Anorectal malformations.
Dkk4 affects an auxiliary pathway for Eda (show EDA ELISA Kits)-independent development of secondary hair
Dkk4 acts in a negative feedback loop to attenuate canonical Wnt (show WNT2 ELISA Kits) signaling and may facilitate a switch to the non-canonical Wnt (show WNT2 ELISA Kits) planar cell polarity pathway that is involved in cell movements during morphogenesis.
Microarray profiling of genes differentially regulated by short exposure to recombinant Eda-A1 (show EDA ELISA Kits) in embryonic eda (show EDA ELISA Kits)(-/-) skin explants, was performed to identify direct targets of ectodysplasin pathway.
We found that TCF7L1 (show TCF3 ELISA Kits) recruits the C-terminal binding protein (CtBP (show CTBP2 ELISA Kits)) and histone deacetylase 1 (HDAC1 (show HDAC1 ELISA Kits)) to the DKK4 promoter to repress DKK4 gene expression. In the absence of TCF7L1 (show TCF3 ELISA Kits), TCF7L2 (show TCF7L2 ELISA Kits) and beta-catenin (show CTNNB1 ELISA Kits) occupancy at the DKK4 promoter is stimulated and DKK4 expression is increased. These findings uncover a critical role for TCF7L1 (show TCF3 ELISA Kits) in repressing DKK4 gene expression to promote the oncogenic potential of CRCs.
DKK4 expression is significantly upregulated in human masticatory mucosa during wound healing
DKK4 may have function on the development and progression of pancreatic cancer.
The recurrence of benign tumors of mammary gland occurred predominantly in women-carriers of mutant alleles with polymorphism rs8190924 of gene GSR (show GSR ELISA Kits) and AA rs3763511of gene DKK4.
DKK4 upregulated by T3/TR antagonizes the Wnt (show WNT2 ELISA Kits) signal pathway to suppress tumor cell progression
rs3923086 in AXIN2 (show AXIN2 ELISA Kits) and rs3763511 in DKK4 that did not show any association in the overall population were significantly associated with early on-set and estrogen receptor (show ESR1 ELISA Kits) negative breast cancers, respectively.
Our findings suggest a potential tumour suppressive role of DKK4 as well as that of an important regulator of HCC (show FAM126A ELISA Kits).
Found the unique expression of the Wnt (show WNT2 ELISA Kits) antagonist DKK4 in SW480APC, but not parental SW480 cell-derived exosomes. Upregulation of DKK4 in SW480APC cells was confirmed by RT-PCR, immunoblotting, and immunogold electron microscopy.
The TR/DKK4/Wnt (show WNT2 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits) cascade influences the proliferation and migration of hepatoma cells during the metastasis process and support a tumor suppressor role of the thyroid hormone receptor (show THRA ELISA Kits).
This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. Activity of this protein is modulated by binding to the Wnt co-receptor and the co-factor kremen 2.
dickkopf homolog 4
, dickkopf-related protein 4