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sweat gland development shows a relay of regulatory steps initiated by Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) - itself modulated by Dkk4 - with subsequent participation of Eda (show EDA Proteins) and Shh (show SHH Proteins) pathways.
These results showed that Dkk4 functions as an inhibitor of osteoblastogenesis through Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling, providing new insights into the relationship between Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling and Dkk4 in bone formation.
It would appear that deregulation of the WNT (show WNT2 Proteins) pathway by overexpression of DKK4 may further impair WNT (show WNT2 Proteins) signaling and lead to Anorectal malformations.
Dkk4 affects an auxiliary pathway for Eda (show EDA Proteins)-independent development of secondary hair
Dkk4 acts in a negative feedback loop to attenuate canonical Wnt (show WNT2 Proteins) signaling and may facilitate a switch to the non-canonical Wnt (show WNT2 Proteins) planar cell polarity pathway that is involved in cell movements during morphogenesis.
Microarray profiling of genes differentially regulated by short exposure to recombinant Eda-A1 (show EDA Proteins) in embryonic eda (show EDA Proteins)(-/-) skin explants, was performed to identify direct targets of ectodysplasin pathway.
We found that TCF7L1 (show TCF3 Proteins) recruits the C-terminal binding protein (CtBP (show CTBP2 Proteins)) and histone deacetylase 1 (HDAC1 (show HDAC1 Proteins)) to the DKK4 promoter to repress DKK4 gene expression. In the absence of TCF7L1 (show TCF3 Proteins), TCF7L2 (show TCF7L2 Proteins) and beta-catenin (show CTNNB1 Proteins) occupancy at the DKK4 promoter is stimulated and DKK4 expression is increased. These findings uncover a critical role for TCF7L1 (show TCF3 Proteins) in repressing DKK4 gene expression to promote the oncogenic potential of CRCs.
DKK4 expression is significantly upregulated in human masticatory mucosa during wound healing
DKK4 may have function on the development and progression of pancreatic cancer.
The recurrence of benign tumors of mammary gland occurred predominantly in women-carriers of mutant alleles with polymorphism rs8190924 of gene GSR (show GSR Proteins) and AA rs3763511of gene DKK4.
DKK4 upregulated by T3/TR antagonizes the Wnt (show WNT2 Proteins) signal pathway to suppress tumor cell progression
rs3923086 in AXIN2 (show AXIN2 Proteins) and rs3763511 in DKK4 that did not show any association in the overall population were significantly associated with early on-set and estrogen receptor (show ESR1 Proteins) negative breast cancers, respectively.
Our findings suggest a potential tumour suppressive role of DKK4 as well as that of an important regulator of HCC (show FAM126A Proteins).
Found the unique expression of the Wnt (show WNT2 Proteins) antagonist DKK4 in SW480APC, but not parental SW480 cell-derived exosomes. Upregulation of DKK4 in SW480APC cells was confirmed by RT-PCR, immunoblotting, and immunogold electron microscopy.
The TR/DKK4/Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) cascade influences the proliferation and migration of hepatoma cells during the metastasis process and support a tumor suppressor role of the thyroid hormone receptor (show THRA Proteins).
This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. Activity of this protein is modulated by binding to the Wnt co-receptor and the co-factor kremen 2.
dickkopf homolog 4
, dickkopf-related protein 4