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|Antigen||Frizzled Family Receptor 1 (Fzd1) Antibodies|
|Epitope||AA 1-248, Extracellular Domain Alternatives|
|Reactivity||Mouse (Murine) Alternatives|
|Conjugate||This FZD1 antibody is un-conjugated Alternatives|
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), ELISA
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Product Details anti-FZD1 AntibodyTarget Details FZD1 Application Details Handling Images
|Specificity||Mouse FZD1 / Frizzled-1|
|Characteristics||Produced in rabbits immunized with purified, recombinant Mouse FZD1 / Frizzled-1 extracellular domain (rh FZD1, ABIN2007309 NP_067432.2, Met 1-His 248,. FZD1 specific IgG was purified by mouse FZD1 affinity chromatography.|
|Purification||purified by affinity chromatography|
|Sterility||0.2 μm filtered|
|Immunogen||Recombinant Mouse FZD1 protein (ABIN2007309)|
Target Details FZD1Product Details anti-FZD1 Antibody Application Details Handling Images back to top
|Alternative Name||FZD1 (Fzd1 Antibody Abstract)|
|Background||Mouse Frizzled-1, also known as FZD1, belongs to the G-protein coupled receptor Fz/Smo family. FZD1 contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, 7 transmembrane domains, and a C-terminal PDZ domain-binding motif. FZD1 is expressed in adult heart, placenta, lung, kidney, pancreas, prostate, and ovary and in fetal lung and kidney. Frizzled is a family of G protein-coupled receptor proteins that serve as receptors in the Wnt signaling pathway and other signaling pathways. When activated, Frizzled leads to activation of Dishevelled in the cytosol. Frizzled proteins and the genes encoding them have been identified in an array of animals, from sponges to humans. Frizzled proteins play key roles in governing cell polarity, embryonic development, formation of neural synapses, cell proliferation, and many other processes in developing and adult organisms. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes.|
|Pathways||WNT Signaling, Asymmetric Protein Localization|
Application DetailsProduct Details anti-FZD1 Antibody Target Details FZD1 Handling Images back to top
ELISA: 0.5-1.0 μg/mL
This antibody can be used at 0.5-1.0 μg/mL with the appropriate secondary reagents to detect Mouse FZD1. The detection limit for Mouse FZD1 is 0.00245 ng/well.
IHC-P: 0.1-1 μg/mL
|Restrictions||For Research Use only|
HandlingProduct Details anti-FZD1 Antibody Target Details FZD1 Application Details Images back to top
|Buffer||0.2 μm filtered solution in PBS with 5 % trehalose|
|Handling Advice||Avoid repeated freeze-thaw cycles.|
|Storage||4 °C,-20 °C,-80 °C|
This antibody can be stored at 2°C-8°C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20°C to -80°C. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
|Expiry Date||12 months|
ImagesProduct Details anti-FZD1 Antibody Target Details FZD1 Application Details Handling back to top