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anti-Human FZD7 Antibodies:
anti-Rat (Rattus) FZD7 Antibodies:
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Chicken Polyclonal FZD7 Primary Antibody for IHC, WB - ABIN2776708
Vincan, Darcy, Smyth, Thompson, Thomas, Phillips, Ramsay: Frizzled-7 receptor ectodomain expression in a colon cancer cell line induces morphological change and attenuates tumor growth. in Differentiation; research in biological diversity 2005
Show all 6 references for ABIN2776708
Human Polyclonal FZD7 Primary Antibody for IF (p), IHC (p) - ABIN710051
Deng, Zhang, Zhang, Wen, Miao, Guo: MicroRNA-142-3p inhibits cell proliferation and invasion of cervical cancer cells by targeting FZD7. in Tumour biology 2015
Human Polyclonal FZD7 Primary Antibody for WB - ABIN374921
Vincan, Darcy, Farrelly, Faux, Brabletz, Ramsay: Frizzled-7 dictates three-dimensional organization of colorectal cancer cell carcinoids. in Oncogene 2007
Chimpanzee FZD7 and cow Fzd7 genes were identified and characterized.
FZD7 activated JNK (show MAPK8 Antibodies) in melanoma cell lines in vitro and the expression of a dominant negative JNK (show MAPK8 Antibodies) suppressed metastasis formation in vivo, suggesting that FZD7 may promote metastatic growth of melanoma cells via activation of JNK (show MAPK8 Antibodies)
conclusion, our study suggests that miR (show MLXIP Antibodies)-613 functions as a tumor suppressor, partially through targeting Fzd7, and is a potential therapeutic target for prostate cancer.
High FZD7 expression is associated with cell migration, invasion, and epithelial-mesenchymal transition of cervical cancer.
High expression of FZD7 is associated with cervical cancer.
Frizzled 7 expression is positively regulated by SIRT1 (show SIRT1 Antibodies) and beta-catenin (show CTNNB1 Antibodies) in breast cancer cells.
Expression of FZD7 was inversely correlated with miR (show MLXIP Antibodies)-199a in both hepatocellular carcinoma tissues and cells and over-expression of miR (show MLXIP Antibodies)-199a significantly down-regulates the expression of genes downstream of FZD7.
Knockdown of FZD7 in Stem-A subtype of ovarian cancer cells showed reduced cell proliferation with an increase in the G0/G1 sub-population.
finding suggests that Wnt (show WNT2 Antibodies) signaling is one of the factors of LSC (show ARHGEF1 Antibodies) niche, and Fz7 helps to maintain the undifferentiated state of LSCs.
Data indicate that Wnt receptor Fzd7-dependent enhancement of Wnt (show WNT2 Antibodies) signalling by DeltaNp63 governs tumour-initiating activity of the basal subtype of breast cancer.
results demonstrate that FZD7 encodes a regulator of the pluripotent state and that hESCs require endogenous WNT (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling through FZD7 to maintain an undifferentiated phenotype
in the foregut Fzd7 signals via both the Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) and Wnt (show WNT2 Antibodies)/JNK (show MAPK8 Antibodies) pathways and different thresholds of Wnt11, 5 and 8-Fzd7 activity coordinate progenitor cell fate, proliferation and morphogenesis
Because paraxial protocadherin and C-cadherin do not directly interact nor form a joint complex with Fz7, Wnt-11 triggers the formation of two distinct complexes that act in parallel to reduce cell adhesion by hampering clustering of C-cadherin.
We therefore demonstrate that Xfz7 is regulated by BMP antagonism and is required for neural crest induction by Wnt (show WNT2 Antibodies) in the developing vertebrate embryo.
Wnt11-induced polarized accumulation of Frizzled7 and Dishevelled (show DVL2 Antibodies) at adherens junctions underlies the formation and maintenance of apicobasal cell polarity.
Results suggest that Ryk (show RYK Antibodies) functions as an essential regulator for noncanonical Wnt11/frizzled 7-mediated endocytosis in the regulation of Xenopus laevis convergent extension movements.
Fzd7 is enriched in Lgr5 (show LGR5 Antibodies)(+) stem cells and binds Wnt3 (show WNT3 Antibodies) and Wnt2b (show WNT2B Antibodies).
the Wnt receptor, frizzled-7, is a downstream target of miR (show MLXIP Antibodies)-184, and delivery of miR (show MLXIP Antibodies)-184 mimic inhibits Wnt (show WNT2 Antibodies) signaling in the OIR retina.
Fzd7 is a new partner of adherens junctional complex and represents a novel molecular switch for the control of vascular permeabilityvia activation of the Wnt (show WNT2 Antibodies)-canonical pathway
observed genetic interactions between Fz2 (show FZD2 Antibodies) and Fz7 and five canonical and/or non-canonical signaling molecules: Dvl3 (show DVL3 Antibodies), Wnt3a (show WNT3A Antibodies), Wnt11 (show WNT11 Antibodies), Vangl2 (show VANGL2 Antibodies), and Wnt5a (show WNT5A Antibodies)
Data show that the Fzd7 receptor complex was associated with Galpha (show SUCLG1 Antibodies)(s) and PI(3 (show PI3 Antibodies))K and these components were required for Wnt7a (show WNT7A Antibodies) to activate the Akt (show AKT1 Antibodies)/mTOR (show FRAP1 Antibodies) growth pathway in myotubes.
Ror2 (show ROR2 Antibodies)/Fz7 receptor complex plays an important role in the Wnt5a (show WNT5A Antibodies)/Rac1/AP-1 (show JUN Antibodies) pathway by regulating the polymerization of Dvl (show DVL1 Antibodies).
Data suggest that upregulation of frizzled-7 receptors in association with activation of the canonical Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) pathway is a common molecular event in hepatocellular carcinoma.
Interprets Wnt (show WNT2 Antibodies) signals during embryonic mesoderm and neural induction.
sFRP-1 (show SFRP1 Antibodies) can interact with Wnt (show WNT2 Antibodies) receptors Frizzled 4 (show FZD4 Antibodies) and 7 on endothelial cells to transduce downstream to cellular machineries requiring Rac-1 activity in cooperation with GSK-3beta (show GSK3b Antibodies)
Direct interaction of Frizzled-1 (show Fzd1 Antibodies), -2, -4, and -7 with PDZ (show INADL Antibodies) domains of PSD-95 (show DLG4 Antibodies). "FZ-2 (show FZD2 Antibodies), Fz-4 (show FZD4 Antibodies), Fz-7"
Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas.
frizzled 7, seven transmembrane spanning receptor
, frizzled homolog 7
, frizzled 7
, Frizzled, drosophila, homolog of, 7