|Antigen||Frizzled Family Receptor 7 (FZD7) Antibodies|
|Reactivity||Human, Mouse (Murine) Alternatives|
|Conjugate||This FZD7 antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Western Blotting (WB)
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Product Details anti-FZD7 AntibodyTarget Details FZD7 Application Details Handling Images
|Specificity||This antibody detects endogenous levels of Frizzled-7 protein.(region surrounding Tyr87)|
Target Details FZD7Product Details anti-FZD7 Antibody Application Details Handling Images back to top
|Alternative Name||FZD7 / Frizzled-7 (FZD7 Antibody Abstract)|
|Background||The frizzled gene, originally identified in Drosophila melanogaster, is involved in the development of tissue polarity. The mammalian homolog of frizzled, as well as several secreted mammalian frizzled-related proteins: FRP-1 (also designated SARP2), FRP-2 (also designated SARP1), FRP-3, FRP-4 and SARP3 (also designated FRP-5), have been identified. The frizzled proteins contain seven transmembrane domains, a cysteine-rich domain in the extracellular region and a carboxy terminal Ser/Thr-xxx-Val motif. They function as receptors for Wnt. frizzled-7 has a Lys-Thr-X-X-X-Trp motif which is involved in the activation of the Wnt/beta-catenin signaling pathway. frizzled-7 is an integral membrane protein showing a high expression in adult skeletal muscle, fetal kidney, fetal lung, adult heart, brain and placenta. It is specifically expressed in squamous cell esophageal carcinomas.Synonyms: Fz-7, mFz7|
|Pathways||WNT Signaling, Stem Cell Maintenance|
Application DetailsProduct Details anti-FZD7 Antibody Target Details FZD7 Handling Images back to top
ELISA: 1/20000approx. 1/40000. Western Blot: 1/500approx. 1/1000. Immunofluorescence: 1/50approx. 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-FZD7 Antibody Target Details FZD7 Application Details Images back to top
|Buffer||Phosphate buffered saline (PBS) with 0.05 % Sodium Azide as preservative, approx. pH 7.2.|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.|
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