|Antigen||G Protein-Coupled Bile Acid Receptor 1 (GPBAR1) Antibodies|
|Reactivity||Mouse (Murine) Alternatives|
|Conjugate||This GPBAR1 antibody is un-conjugated Alternatives|
Immunohistochemistry (IHC), Western Blotting (WB)
|Supplier||Log in to see|
Product Details anti-GPBAR1 AntibodyTarget Details GPBAR1 Application Details Handling Images
|Specificity||Specific for GPCR TGR5.|
|Immunogen||A synthetic peptide from c-terminal region of mouse GPCR TGR5 (GPBAR1) conjugated to an immunogenic carrier protein was used as the antigen.|
Target Details GPBAR1Product Details anti-GPBAR1 Antibody Application Details Handling Images back to top
|Alternative Name||GPCR TGR5 (GPBAR1 Antibody Abstract)|
Function: Receptor for bile acid. Bile acid-binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP production. May be involved in the suppression of macrophage functions by bile acids. Involved in bile acid promoted GLP1R secretion.
Tissue specificity: Ubiquitously expressed. Expressed at higher level in spleen and placenta. Expressed at lower level in other tissues. In digestive tissues, it is expressed in stomach, duodenum, ileocecum, ileum, jejunum, ascending colon, transverse colon, descending colon, cecum and liver, but not in esophagus and rectum.
Subcellular location: Cell membrane, Multi-pass membrane protein Also known as: GPBAR, GPBAR1, Membrane-type receptor for bile acids, M-BAR, Tgr5, G protein coupled bile acid receptor 1.
Application DetailsProduct Details anti-GPBAR1 Antibody Target Details GPBAR1 Handling Images back to top
A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-GPBAR1 Antibody Target Details GPBAR1 Application Details Images back to top
|Reconstitution||Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.|
|Handling Advice||Avoid freeze and thaw cycles.|
|Storage||4 °C/-20 °C|
|Storage Comment||Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.|
|Expiry Date||12 months|