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|Antigen||Insulin-Like Growth Factor Binding Protein 4 (IGFBP4) Antibodies|
|Reactivity||Human, Mouse (Murine) Alternatives|
|Conjugate||This IGFBP4 antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Western Blotting (WB)
|2 references available|
|Supplier||Log in to see|
Product Details anti-IGFBP4 AntibodyTarget Details IGFBP4 Application Details Handling References for anti-IGFBP4 antibody (ABIN453124) Images
|Specificity||This antibody recognizes IGFBP4 (N-term).|
|Cross-Reactivity (Details)||Species reactivity (tested):Human and Mouse.|
|Purification||Affinity Chromatography on Protein A|
|Immunogen||KLH conjugated synthetic peptide selected from the N-terminal region of Human IGFBP4.|
Target Details IGFBP4Product Details anti-IGFBP4 Antibody Application Details Handling References for anti-IGFBP4 antibody (ABIN453124) Images back to top
|Alternative Name||IGFBP4 (IGFBP4 Antibody Abstract)|
|Background||IGFBP4 has an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma in both glycosylated and non-glycosylated forms. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors.Synonyms: IBP-4, IBP4, IGF-binding protein 4, IGFBP-4, Insulin-like growth factor-binding protein 4|
|Molecular Weight||27934 Da|
|Research Area||Signaling, Extracellular Matrix, Angiogenesis|
|Pathways||WNT Signaling, Myometrial Relaxation and Contraction, Regulation of Carbohydrate Metabolic Process|
Application DetailsProduct Details anti-IGFBP4 Antibody Target Details IGFBP4 Handling References for anti-IGFBP4 antibody (ABIN453124) Images back to top
ELISA: 1/1,000. Western blotting: 1/100-1/500.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-IGFBP4 Antibody Target Details IGFBP4 Application Details References for anti-IGFBP4 antibody (ABIN453124) Images back to top
|Buffer||PBS with 0.09 % (W/V) Sodium Azide as preservative|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.|
References for anti-IGFBP4 antibody (ABIN453124)Product Details anti-IGFBP4 Antibody Target Details IGFBP4 Application Details Handling Images back to top
Durai, Yang, Sales, Seifalian, Goldspink, Winslet: "Increased apoptosis and decreased proliferation of colorectal cancer cells using insulin-like growth factor binding protein-4 gene delivered locally by gene transfer." in: Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland, Vol. 9, Issue 7, pp. 625-31, 2007
Laursen, Kjaer-Sorensen, Andersen, Oxvig: "Regulation of insulin-like growth factor (IGF) bioactivity by sequential proteolytic cleavage of IGF binding protein-4 and -5." in: Molecular endocrinology (Baltimore, Md.), Vol. 21, Issue 5, pp. 1246-57, 2007
ImagesProduct Details anti-IGFBP4 Antibody Target Details IGFBP4 Application Details Handling References for anti-IGFBP4 antibody (ABIN453124) back to top