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|Antigen||Insulin-Like Growth Factor Binding Protein 4 (IGFBP4) Antibodies|
|Epitope||AA 1-254 Alternatives|
|Reactivity||Mouse (Murine) Alternatives|
|Conjugate||This IGFBP4 antibody is un-conjugated Alternatives|
|1 reference available|
|Supplier||Log in to see|
Product Details anti-IGFBP4 AntibodyTarget Details IGFBP4 Application Details Handling References for anti-IGFBP4 antibody (ABIN2000637) Images
|Characteristics||Produced in rabbits immunized with purified, recombinant Mouse IGFBP4 (rM IGFBP4, ABIN2007571 NP_034647.1, Met 1-Glu 254,. IGFBP4 specific IgG was purified by Mouse IGFBP4 affinity chromatography.|
|Purification||purified by affinity chromatography|
|Sterility||0.2 μm filtered|
|Immunogen||Recombinant Mouse IGFBP4 protein (ABIN2007571)|
Target Details IGFBP4Product Details anti-IGFBP4 Antibody Application Details Handling References for anti-IGFBP4 antibody (ABIN2000637) Images back to top
|Alternative Name||IGFBP4 (IGFBP4 Antibody Abstract)|
|Background||Insulin-like growth factor binding protein 4 (IGFBP-4) is a 24-kDa protein that binds insulin-like growth factor 1 (IGF-1) and IGF-2 with high affinity and inhibits IGF action in vitro. The Insulin-like growth factor-binding protein also known as IGFBP serves as a carrier protein for Insulin-like growth factor 1. IGFBPs are clearly distinct but are sharing regions with strong homology. All members of the IGFBP family bind IGF-I and IGF-II with about equal affinity. Insulin-like growth factor (IGF) binding proteins (IGFBPs) have been shown to either inhibit or enhance the action of IGF, or act in an IGF-independent manner in the prostate. IGF-binding protein-4 (IGFBP-4) inhibits IGF-I action in vitro and is the most abundant IGFBP in the rodent arterial wall. Expression of IGFBP-4 mRNA in nontransgenic littermates was maximal in liver and kidney. IGFBP-4 is a functional antagonist of IGF-I action on SMC. There is mounting evidence that the structure of the IGFBP proteins plays a key role in the regulation of IGF bioavailability, by modulating its molecular size, capillary membrane permeability, target tissue specificity, cell membrane adherence and IGF affinity.|
|Research Area||Signaling, Extracellular Matrix, Angiogenesis|
|Pathways||WNT Signaling, Myometrial Relaxation and Contraction, Regulation of Carbohydrate Metabolic Process|
Application DetailsProduct Details anti-IGFBP4 Antibody Target Details IGFBP4 Handling References for anti-IGFBP4 antibody (ABIN2000637) Images back to top
ELISA: 0.1-0.2 μg/mL
This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Mouse IGFBP4. The detection limit for Mouse IGFBP4 is approximately 0.039 ng/well.
|Restrictions||For Research Use only|
HandlingProduct Details anti-IGFBP4 Antibody Target Details IGFBP4 Application Details References for anti-IGFBP4 antibody (ABIN2000637) Images back to top
|Buffer||0.2 μm filtered solution in PBS with 5 % trehalose|
|Handling Advice||Avoid repeated freeze-thaw cycles.|
|Storage||4 °C,-20 °C,-80 °C|
This antibody can be stored at 2°C-8°C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20°C to -80°C. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
|Expiry Date||12 months|
References for anti-IGFBP4 antibody (ABIN2000637)Product Details anti-IGFBP4 Antibody Target Details IGFBP4 Application Details Handling Images back to top
Chernausek, Smith, Duffin, Busby, Wright, Clemmons: "Proteolytic cleavage of insulin-like growth factor binding protein 4 (IGFBP-4). Localization of cleavage site to non-homologous region of native IGFBP-4." in: The Journal of biological chemistry, Vol. 270, Issue 19, pp. 11377-82, 1995