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Results shed light on the mechanism of IGFBP5 as a potential tumor-suppressor in melanoma progression.
data provide further insights into the role of cellular compartmentalization in IGFBP-5-induced fibrosis
Demethylation of IGFBP5 by Histone Demethylase KDM6B Promotes Mesenchymal Stem Cell-Mediated Periodontal Tissue Regeneration by Enhancing Osteogenic Differentiation and Anti-Inflammation Potentials.
Our results suggest that rs6214 on the IGF1 (show IGF1 Proteins) gene and rs2854744 near the IGFBP3 (show IGFBP3 Proteins) gene potentially play an important role with ASMI in Taiwanese older adults in a metropolitan area.
Data indicate co-localization of insulin (show INS Proteins)-like growth factor binding proteins IGFBP-4 (show IGFBP4 Proteins), IGFBP-5 in the syncytiotrophoblast layer of first trimester placental villi as early as 5 weeks of gestational age.
rs4442975 at 2q35 flanks a transcriptional enhancer that physically interacts with the promoter of IGFBP5. Evidence suggests that the g-allele confers increased breast cancer susceptibility through relative downregulation of IGFBP5.
IGFBP5 mRNA expression is a good indicator in clinical outcome of breast cancer patients.
miR (show MLXIP Proteins)-204-5p suppresses IGFBP5 expression by direct binding to the 3' untranslated region.
IGFBP-5 may be a negative modulator of RASSF1C (show RASSF1 Proteins)/ PIWIL1 (show PIWIL1 Proteins) growth-promoting activities.
IGFBP-5 induces its pro-fibrotic effects, at least in part, via DOK5 (show DOK5 Proteins). IGFBP-5 and DOK5 (show DOK5 Proteins) are both increased in systemic sclerosis fibroblasts and tissues and may thus be acting in concert to promote fibrosis.
proliferation of IGFBP5-mutated cancer cells is selectively blocked by IGF-1R (show IGF1R Proteins) inhibitors
Results from mouse models suggest that inhibiting the up-regulation of IGFBP5 expression in peripheral nerves might prevent or slow down diabetic neuropathy disease progression
Igfbp2-5 are expressed in distinct and complementary patterns during cochlear development.
indicate that Igf1 (show IGF1 Proteins) was highly expressed in the mesenchyme, Igf2 and Igf1r (show IGF1R Proteins) were expressed in both the midline epithelium and surrounding mesenchyme, and Igfbp5 was highly expressed in the epithelium.
we have identified a single polymorphic locus that affects skin and lung tumorigenesis and identify Igfbp5 and Igfbp2 as candidate modifier genes of lung tumorigenesis.
investigated the effect of IGFBP5 induction on the progression of liver fibrosis caused by chronic cholangiopathy; expression of IGFBP5 in the Abcb4 (show ABCB4 Proteins)-/- mice reduces inflammation, oxidative stress, ECM (show MMRN1 Proteins) deposition and hepatocyte proliferation, thereby reducing liver fibrosis
c-Src (show SRC Proteins) and IL-6 (show IL6 Proteins) inhibit osteoblast differentiation and integrate IGFBP5 signalling
Defining the disulfide bonds of insulin-like growth factor-binding protein-5 by tandem mass spectrometry with electron transfer dissociation and collision-induced dissociation.
Decreased Cav-1 (show CAV1 Proteins) expression in fibrotic diseases likely leads to increased deposition of IGFBP-5 in the extracellular matrix.
This study suggested that that higher level IGFBP-5 expression may have functional significance in lactation persistency.
follicular dominance was associated with low or decreased follicular fluid concentrations of IGFBP-4 (show IGFBP4 Proteins) and -5
GH reduces mRNA and protein expression of IGFBP-5 in bovine mammary epithelial cells, but it does not affect the expression of IGFBP-3 (show IGFBP3 Proteins)
The present study revealed SNPs in exon 1 of IGFBP-5 gene (show GPD1 Proteins) in the Tibet Mini-pig, possibly providing more understanding of the mechanism of miniaturization
IGFBP-5 gene (show GPD1 Proteins) is associated with the variation in meat quality, especially in pH value together with other QTLs on chromosome 15.
Endogenous IGFBP-5 or transiently expressed IGFBP-5-EGFP is localized in the nuclei of VSMCs. It possesses transcription-regulatory activity that is IGF independent.
The transgene in the cell clones was examined by polymerase chain reaction to verify that exogenous DNA (pKAP6-1 and IGFBP-5) had integrated stably into GFb cells
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
insulin-like growth factor binding protein 5
, IGF-binding protein 5
, insulin-like growth factor-binding protein 5
, insulin-like growth factor binding protein-5