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anti-Human KREMEN1 Antibodies:
anti-Mouse (Murine) KREMEN1 Antibodies:
anti-Rat (Rattus) KREMEN1 Antibodies:
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Mouse (Murine) Polyclonal KREMEN1 Primary Antibody for CyTOF, FACS - ABIN4899514
Diarra, Stolina, Polzer, Zwerina, Ominsky, Dwyer, Korb, Smolen, Hoffmann, Scheinecker, van der Heide, Landewe, Lacey, Richards, Schett: Dickkopf-1 is a master regulator of joint remodeling. in Nature medicine 2007
Structure of the dual-mode Wnt (show WNT2 Antibodies) regulator Kremen1 and insight into ternary complex formation with LRP6 (show LRP6 Antibodies) and DKK1 (show DKK1 Antibodies) have been presented.
Ectodermal dysplasia including oligodontia is due to homozygosity for KREMEN1 p.F209S (c.626 T>C).
Kremen1 has a pro-apoptotic activity that is decreased upon Dkk1 (show DKK1 Antibodies) binding or by cancer mutations.
Six Dkk-1 (show DKK1 Antibodies), three Sost (show SOST Antibodies), one Kremen-1 and 10 LRP-5 (show LRP5 Antibodies) polymorphisms were significantly associated with radiological progression of rheumatoid arthritis joint destruction.
The mRNA expression levels of DKK-1 (show DKK1 Antibodies) binding receptor LRP5 (show LRP5 Antibodies)/6 and Krm1/2 in SCs (show TWIST1 Antibodies) from patients with MM were significantly higher than those in myeloma cells and in SCs (show TWIST1 Antibodies) from healthy donors.
This study demonstrated that a representative tSNP of KREMEN1 might modulate the risk of schizophrenia in the Japanese population.
Kremen may not be essential for Dkk1 (show DKK1 Antibodies)-mediated Wnt (show WNT2 Antibodies) antagonism and Kremen may only play a role when cells express a high level of LRP5 (show LRP5 Antibodies)/6
Functional characterization (show DKK1 Antibodies)of related Kremen proteins i (show WNT2 Antibodies)n mouse.
Kremen1 has a pro-apoptotic activity that is decreased upon Dkk1 (show DKK1 Antibodies) binding
Kremen proteins are Dickkopf (show DKK1 Antibodies) receptors that regulate Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signalling
Dkk1 (show DKK1 Antibodies) and Kremen1 play roles in blastocyst activation and uterine receptivity during the window of implantation.
This study provides the first genetic evidence for a functional interaction of Kremen proteins with Dkk1 (show DKK1 Antibodies) as negative regulators of Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling.
Kremen1 modulates Wnt (show WNT2 Antibodies) activity by restricting the range of secreted Dkk (show DKK1 Antibodies) proteins during collective cell migration in the posterior lateral line primordium
This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein is a component of a membrane complex that modulates canonical WNT signaling through lipoprotein receptor-related protein 6 (LRP6). It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene.
kringle containing transmembrane protein 1
, kringle-containing transmembrane protein 1
, kremen 1
, kremen protein 1-like
, dickkopf receptor
, kremen protein 1
, kringle domain-containing transmembrane protein 1
, kringle-coding gene marking the eye and the nose
, kringle-containing protein marking the eye and the nose