Browse our LEF1 Proteins (LEF1)

Full name:
Lymphoid Enhancer-Binding Factor 1 Proteins (LEF1)
On are 7 Lymphoid Enhancer-Binding Factor 1 (LEF1) Proteins from 4 different suppliers available. Additionally we are shipping LEF1 Antibodies (129) and LEF1 Kits (3) and many more products for this protein. A total of 149 LEF1 products are currently listed.
3000002B05, AI451430, LEF-1, LEF1, TCF1ALPHA, TCF7L3, TCF10
list all proteins Gene Name GeneID UniProt
LEF1 16842 P27782
LEF1 161452 Q9QXN1
LEF1 51176 Q9UJU2

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LEF1 Proteins (LEF1) by Origin

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Top referenced LEF1 Proteins

  1. Human LEF1 Protein expressed in Wheat germ - ABIN1309292 : Shimomura, Takasaki, Nomura, Hayashi, Senda: Identification of DNA-dependent protein kinase catalytic subunit as a novel interaction partner of lymphocyte enhancer factor 1. in Medical molecular morphology 2013 (PubMed)

More Proteins for LEF1 Interaction Partners

Zebrafish Lymphoid Enhancer-Binding Factor 1 (LEF1) interaction partners

  1. Amotl2a (show AMOTL2 Proteins) function in the control of lateral line primordium cell proliferation is mediated together by the Hippo pathway effector Yap1 (show YAP1 Proteins) and the Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) effector Lef1.

  2. Lef1 has a role in regulating Dusp6 (show DUSP6 Proteins) in formation of the zebrafish posterior lateral line primordium

  3. Nlk2 (show NLK Proteins) is essential for the phosphorylation and activation of Lef1 transcriptional activity in neural progenitor cells.

  4. Lef1 is required for progenitor cell identity in the zebrafish lateral line primordium.

  5. Lef1 sustains proliferation of leading zone progenitors, maintaining the primordium size and defining neuromast deposition rate.

  6. Data conclude that lef1-mediated Wnt (show WNT2 Proteins) signaling is involved in various aspects of primordium migration, although part of this implication is masked by a high level of developmental redundancy.

  7. Data show cooperation between Dnmt3 and an H3K9 methyltransferase G9a (show EHMT2 Proteins) in regulating lef1.

  8. high-affinity binding sites for Tcf (show HNF4A Proteins)/Lef1 within the boz promoter region

  9. Canonical Wnt (show WNT2 Proteins) signaling through Lef1 is required for hypothalamic neurogenesis.

  10. Domain-specific regulation of foxP2 (show FOXP2 Proteins) CNS expression by lef1.

Mouse (Murine) Lymphoid Enhancer-Binding Factor 1 (LEF1) interaction partners

  1. Uncovering a Pitx2 (show PITX2 Proteins)-Sox2 (show SOX2 Proteins)-Lef-1 transcriptional mechanism that regulates dental epithelial stem cells homeostasis and dental development.

  2. this study shows that the transcription factors Tcf1 (show HNF1A Proteins) and Lef1 suppress CD4 (show CD4 Proteins)+ T lineage genes in CD8 (show CD8A Proteins)+ T cells through intrinsic histone deacetylase (show HDAC1 Proteins) activity

  3. leukemic stem cells are therefore more sensitive to loss of Tcf1 (show HNF1A Proteins) and Lef1 than Hematopoietic Stem Cells in their self-renewal capacity.

  4. Sp5 (show SP5 Proteins)/8 bind directly to GC boxes in Wnt (show WNT2 Proteins) target gene enhancers and to adjacent, or distally positioned, chromatin-bound T-cell factor (Tcf) 1 (show HNF1A Proteins)/lymphoid enhancer factor (Lef) 1 to facilitate recruitment of beta-catenin (show CTNNB1 Proteins) to target gene enhancers.

  5. This paper demonstrates a cell-intrinsic requirement for transcription factors TCF1 (show HNF1A Proteins) and LEF1 for the development of all subsets of Natural Killer T cells.

  6. this study gives new insights into transcriptional regulating mechanisms of Wnt (show WNT2 Proteins)-mediated Isl1 (show ISL1 Proteins) expression during cardiomyocyte differentiation.

  7. data reveal LEF1 as a central regulator of iNKT cell number and Th2-type effector differentiation.

  8. These findings provide evidence for the existance of a posititve feedback loop connecting survivin expression in tumor cells to PI3K/Akt enhanced beta-catenin-Tcf/Lef-dependent transcription followed by secretion of VEGF and angiogenesis.

  9. TDG (show TDG Proteins), as a new coactivator, promotes beta-catenin (show CTNNB1 Proteins)/TCFs transactivation and functionally cooperates with CBP (show CREBBP Proteins) in canonical Wnt (show WNT2 Proteins) signaling.

  10. TCF-1 (show HNF1A Proteins) and LEF-1 adopted distinct genetic 'wiring' to promote the CD4 (show CD4 Proteins)(+) T cell fate and establish CD8 (show CD8A Proteins)(+) T cell identity.

Xenopus laevis Lymphoid Enhancer-Binding Factor 1 (LEF1) interaction partners

  1. Tcf (show HNF4A Proteins)/Lef genes encode factors of different activities, which function together in antagonistic or synergistic ways to modulate the intensity and outcome of Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signalling and to trigger tissue-specific responses.

  2. Interaction of Xom and LEF1/TCF (show HNF4A Proteins)-factors is essential for ventral cell fate determination and LEF1/TCF (show HNF4A Proteins) factors may function as a point of convergence to mediate the combined signaling of Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) and BMP4 (show BMP4 Proteins)/Xom pathways during early embryogenesis.

Human Lymphoid Enhancer-Binding Factor 1 (LEF1) interaction partners

  1. Data indicate that microRNA miR (show MLXIP Proteins)-27a directly targets GSK-3beta and increases expression of beta-catenin (show CTNNB1 Proteins) and LEF1 in all-trans-retinoic acid (ATRA)-induced Hep2 cells.

  2. and CTU1 (show CTU1 Proteins)/2, partner enzymes in U34 methoxycarbonylmethyl-2-thio (show ACAA1 Proteins) tRNA modification, are up-regulated in human breast cancers and sustain metastasis.

  3. EVI1 (show MECOM Proteins) transcription is directly regulated by LEF1/beta-catenin (show CTNNB1 Proteins) complex in myeloid blast crisis of chronic myeloid leukemia (show BCL11A Proteins). Loss of p53 (show TP53 Proteins) function as a key regulator for beta-catenin (show CTNNB1 Proteins)-EVI1 (show MECOM Proteins) in myeloid blast crisis of chronic myeloid leukemia (show BCL11A Proteins).

  4. LEF1 is a sensitive and specific marker for chronic lymphocytic B-cell leukemia

  5. a frequency of 4-9% expression of LEF1 bymantle cell lymphoma

  6. The results suggest a role for beta-catenin (show CTNNB1 Proteins)/LEF1-mediated transcription in both malignant transformation and metastasis of prostate cancer

  7. The results describe a novel mutation in LEF1 causing dysregulation of Wnt/B catenin signaling in eyelid sebaceous cancinoma

  8. LEF-1 and MITF (show MITF Proteins) regulate tyrosinase (show TYR Proteins) gene transcription in vitro via binding to its promoter.

  9. Methylprednisolone can suppress Wnt (show WNT2 Proteins) signaling pathway by down-regulating LEF-1 protein expression in chronic lymphocyte leukemia cells.

  10. Overexpression of LEF1 is a favorable prognostic factor in childhood ALL.

Pig (Porcine) Lymphoid Enhancer-Binding Factor 1 (LEF1) interaction partners

  1. The molecular characterisation of the porcine LEF1 gene and its association with number of teats and inverted teats in experimental and commercial populations, is described.

LEF1 Protein Profile

Protein Summary

This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. This transcription factor is involved in the Wnt signaling pathway, and it may function in hair cell differentiation and follicle morphogenesis. Mutations in this gene have been found in somatic sebaceous tumors. This gene has also been linked to other cancers, including androgen-independent prostate cancer. Alternative splicing results in multiple transcript variants.

Alternative names and synonyms associated with LEF1

  • lymphoid enhancer-binding factor 1 (LEF1)
  • lymphoid enhancer-binding factor 1 (LOC100352691)
  • lymphoid enhancer-binding factor 1 (lef1)
  • lymphocyte enhancer binding factor 1 (lef1)
  • lymphoid enhancer binding factor 1 (Lef1)
  • lymphoid enhancer factor XLEF-1B (lef1)
  • 3000002B05 protein
  • AI451430 protein
  • LEF-1 protein
  • LEF1 protein
  • TCF1ALPHA protein
  • TCF7L3 protein
  • TCF10 protein

Protein level used designations for LEF1

lymphoid enhancer binding factor-1 , lymphoid enhancer-binding factor 1 , lymphoid enhancer-binding factor 1-like , etID310027.1 , LEF-1 , lymphoid enhancer binding factor 1 short isoform , T cell-specific transcription factor 1-alpha , TCF1-alpha , lymphiod enhancer binding factor 1 , transcription factor LEF-1 , lymphoid enhancer binding factor 1

461425 Pan troglodytes
695776 Macaca mulatta
100011783 Monodelphis domestica
100352691 Oryctolagus cuniculus
100399759 Callithrix jacchus
100447785 Pongo abelii
100465982 Ailuropoda melanoleuca
100556215 Anolis carolinensis
100593051 Nomascus leucogenys
30701 Danio rerio
16842 Mus musculus
161452 Rattus norvegicus
779101 Xenopus laevis
51176 Homo sapiens
395865 Gallus gallus
478507 Canis lupus familiaris
100170126 Sus scrofa
535399 Bos taurus
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