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|Application / Reactivity||Human|
|Enzyme Immunoassay (EIA)||3 Antibodies|
|Flow Cytometry (FACS)||1 Antibodies|
|Immunocytochemistry (ICC)||1 Antibodies|
|Immunofluorescence (Cultured Cells) (IF (cc))||11 Antibodies|
|Immunofluorescence (Paraffin-embedded Sections) (IF (p))||13 Antibodies|
|Immunohistochemistry (IHC)||28 Antibodies|
|Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))||2 Antibodies|
|Immunohistochemistry (Frozen Sections) (IHC (fro))||1 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||19 Antibodies|
|Immunoprecipitation (IP)||1 Antibodies|
|Western Blotting (WB)||33 Antibodies|
|Antigen||Low Density Lipoprotein Receptor-Related Protein 6 (LRP6) Antibodies|
|Epitope||AA 1531-1560, C-Term Alternatives|
|Conjugate||This LRP6 antibody is un-conjugated Alternatives|
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
|4 references available|
|Supplier||Log in to see|
Product Details anti-LRP6 AntibodyTarget Details LRP6 Application Details Handling References for anti-LRP6 Antibody (ABIN390100) Images
|Specificity||This LRP6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1538~1568 amino acids from the C-terminal region of human LRP6.|
|Purification||This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Immunogen||This LRP6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1531-1560 AA from the C-terminal region of human LRP6.|
Target Details LRP6Product Details anti-LRP6 Antibody Application Details Handling References for anti-LRP6 Antibody (ABIN390100) Images back to top
|Alternative Name||LRP6 (LRP6 Antibody Abstract)|
LRP6 is essential for the Wnt/beta catenin signaling pathway, probably by acting as a coreceptor together with Frizzled for Wnt. It is a specific, high-affinity receptor for DKK1 and DKK2, but not DKK3. The interaction with DKK1 blocks LRP6-mediated Wnt/beta catenin signaling via LRP6 removal via Kremen proteins-mediated endocytosis.
Synonyms: LDL receptor-related protein 6
|Molecular Weight||180442 DA|
|Research Area||Stem Cells, Cell Structure|
Application DetailsProduct Details anti-LRP6 Antibody Target Details LRP6 Handling References for anti-LRP6 Antibody (ABIN390100) Images back to top
|Application Notes||WB = 1:1000, IHC (p) = 1:10-50|
|Restrictions||For Research Use only|
HandlingProduct Details anti-LRP6 Antibody Target Details LRP6 Application Details References for anti-LRP6 Antibody (ABIN390100) Images back to top
|Buffer||PBS with 0.09 % (W/V) sodium azide|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Storage||4 °C/-20 °C|
|Storage Comment||Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.|
|Expiry Date||6 months|
References for anti-LRP6 Antibody (ABIN390100)Product Details anti-LRP6 Antibody Target Details LRP6 Application Details Handling Images back to top
|Product cited in:||
Ye, Go, Singh et al.: "LRP6 protein regulates low density lipoprotein (LDL) receptor-mediated LDL uptake." in: The Journal of biological chemistry, Vol. 287, Issue 2, pp. 1335-44, 2012 (PubMed).
Keramati, Singh, Lin et al.: "Wild-type LRP6 inhibits, whereas atherosclerosis-linked LRP6R611C increases PDGF-dependent vascular smooth muscle cell proliferation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, Issue 5, pp. 1914-8, 2011 (PubMed).
Liu, Prior, Piwnica-Worms et al.: "LRP6 overexpression defines a class of breast cancer subtype and is a target for therapy." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 11, pp. 5136-41, 2010 (PubMed).
Brown, Twells, Hey et al.: "Isolation and characterization of LRP6, a novel member of the low density lipoprotein receptor gene family." in: Biochemical and biophysical research communications, Vol. 248, Issue 3, pp. 879-88, 1998 (PubMed).
ImagesProduct Details anti-LRP6 Antibody Target Details LRP6 Application Details Handling References for anti-LRP6 Antibody (ABIN390100) back to top