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Human LRP6 ELISA Kit for Sandwich ELISA - ABIN418804
Goetzl, Boxer, Schwartz, Abner, Petersen, Miller, Carlson, Mustapic, Kapogiannis: Low neural exosomal levels of cellular survival factors in Alzheimer's disease. in Annals of clinical and translational neurology 2015
Lrp6 asymmetry is controlled by Wnt (show WNT2 ELISA Kits)/PCP (show PRCP ELISA Kits) signaling, indicating that this pathway regulates not only planar- but also apicobasal cell polarity.
PTK7 (show PTK7 ELISA Kits) and LRP6 proteins physically interact, suggesting that PTK7 (show PTK7 ELISA Kits) stabilization of LRP6 protein reciprocally regulates both canonical and noncanonical Wnt (show WNT2 ELISA Kits) activities in the embryo.
Results suggest that Rap2 (show RAP2A ELISA Kits) acts via TNIK (show TNIK ELISA Kits) to regulate the stability of LRP6 receptor for Wnt (show WNT2 ELISA Kits) signaling.
The extracellular domains of Lrp5 (show LRP5 ELISA Kits)/6 behave as physiologically relevant inhibitors of noncanonical Wnt (show WNT2 ELISA Kits) signaling during Xenopus and mouse development in vivo.
Lrp6 plays a critical role in the switch from Wnt (show WNT2 ELISA Kits)/PCP (show PRCP ELISA Kits) to Wnt (show WNT2 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits) signaling.
Kremen2 (show KREMEN2 ELISA Kits) knockdown specifically reduces LRP6 protein levels in neural crest explants.
Waif1a binds to the Wnt (show WNT2 ELISA Kits) coreceptor LRP6 (show LRP5 ELISA Kits) and inhibits Wnt (show WNT2 ELISA Kits)-induced LRP6 (show LRP5 ELISA Kits) internalization into endocytic vesicles, a process that is required for pathway activation.
Results identify GRK5 (show GRK5 ELISA Kits)/6 as novel kinases for the single transmembrane receptor LRP6 (show LRP5 ELISA Kits) during Wnt (show WNT2 ELISA Kits) signaling.
LRP6 ectodomain becomes highly compact upon complexation with the Wnt (show WNT2 ELISA Kits) antagonist Dkk1 (show DKK1 ELISA Kits), suggesting a potential role for the ectodomain conformational change in the regulation of receptor oligomerization and signaling.
identify ANGPTL4 (show ANGPTL4 ELISA Kits) as a Wnt (show WNT2 ELISA Kits) signaling antagonist that binds to syndecans and forms a ternary complex with the Wnt (show WNT2 ELISA Kits) co-receptor Lipoprotein receptor-related protein 6
The authors show that folding of the Wnt (show WNT2 ELISA Kits) signaling coreceptor LRP6 is promoted by ubiquitination of a specific lysine, retaining it in the ER while avoiding degradation.
Taken together, this study reveals evidence demonstrating a mechanism by which the LPR6/ GSK3beta (show GSK3b ELISA Kits)/E2F1 (show E2F1 ELISA Kits) axis-upregulated LSH (show HELLS ELISA Kits) promoted gliomas.
Structure of the dual-mode Wnt (show WNT2 ELISA Kits) regulator Kremen1 (show KREMEN1 ELISA Kits) and insight into ternary complex formation with LRP6 and DKK1 (show DKK1 ELISA Kits) have been presented.
VAP1 (show AOC3 ELISA Kits) cleaved the extracellular region of LRP6 at Glu1196-Leu1197, the C-terminus of the 4th propeller domain. This cleavage removes four inhibito (show AOC3 ELISA Kits)ry beta-propeller st (show CDH5 ELISA Kits)ructures, resulting in activation of LRP5/6.
We identified a frameshift (c.4594delG, p.Cys1532fs) and a canonical splice-site mutation (c.3398-2A>C, p.?) in LRP6, respectively, in the patient with tooth agenesis (TA) and orofacial clefting (OFC) and in the patient with severe TA only. Mutations in LRP6 cause TA in humans
findings revealed an unrecognized role of Caprin-2 (show CAPRIN2 ELISA Kits) in facilitating LRP5 (show LRP5 ELISA Kits)/6 constitutive phosphorylation at G2/M through forming a quaternary complex with CDK14 (show CDK14 ELISA Kits), Cyclin Y (show CCNY ELISA Kits), and LRP5 (show LRP5 ELISA Kits)/6.
results suggest that miR (show MLXIP ELISA Kits)-29b inhibits expression of LRP6 and HuR (show ELAVL1 ELISA Kits) post-transcriptionally, thus playing a role in the regulation of IEC proliferation and intestinal epithelial homoeostasis.
Mutant LRP6 Impairs Endothelial Cell Functions Associated with Familial Normolipidemic Coronary Artery Disease.
VAP1 (show AOC3 ELISA Kits) cleaved recombinant mouse LRP6, producing a 140-kDa fragment. An antibody against a peptide including the LRP6-cleavage site inhibited VAP1 (show AOC3 ELISA Kits)-induced VE-cadherin (show CDH5 ELISA Kits) relocation and disruption of cell-cell adhesions and blocked haemorrhage in mice in vivo.
we identified Lrp6, the gene encoding the coreceptor to Frizzled in the Wnt (show WNT2 ELISA Kits) pathway, as a potential negative regulator of precursor proliferation. Overexpression and siRNA silencing confirmed the regulatory role of Lrp6
These results revealed a new role of the canonical Lrp5 (show LRP5 ELISA Kits)/6-beta-catenin (show CTNNB1 ELISA Kits) pathway in regulating the morphogenesis of the cerebellum during postnatal development.
Data (including data from studies in knockout/transgenic mice) suggest Lrp6 is required for suppression of Sost (sclerostin (show SOST ELISA Kits)) expression by parathyroid hormone (show PTH ELISA Kits) (here, human PTH (show PTH ELISA Kits) peptide 1-34); LRP6 regulates osteocytes expression of histone deacetylases.
Lrp5 (show LRP5 ELISA Kits) binds to Frizzled, preventing Frz-regulated non-canonical Wnt (show WNT2 ELISA Kits) pathway activation and further non-canonical pathway-mediated tumour metastasis.
Wt1 (show WT1 ELISA Kits) expression levels in podocytes regulate Wnt (show WNT2 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits) signaling through modulating the endocytic fate of LRP6, and this indicates a potential target for the therapy of CKD.
N-cadherin (show CDH2 ELISA Kits) modulates Lrp6/PTHR1 (show PTH1R ELISA Kits) interaction, restraining the intensity of parathyroid hormone (show PTH ELISA Kits)-induced beta-catenin (show CTNNB1 ELISA Kits) signaling
LRP6 restrains vascular smooth muscle lineage noncanonical signals that promote osteochondrogenic differentiation, mediated in part via USF1 (show USF1 ELISA Kits)- and arginine methylation-dependent relays.
Urotensin II (show UTS2 ELISA Kits) inhibited the proliferation of cardiac side population cells by JNK (show MAPK8 ELISA Kits)/LRP6 signalling during pressure overload.
Hgf (show HGF ELISA Kits) as an important transactivator of canonical Wnt (show WNT2 ELISA Kits) signaling that is mediated by Met-stimulated, Gsk3 (show GSK3b ELISA Kits)-dependent Lrp5 (show LRP5 ELISA Kits)/6 phosphorylation
This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.
low density lipoprotein receptor-related protein 6
, lipoprotein receptor-related protein 6
, low-density lipoprotein receptor-related protein 6
, low-density lipoprotein receptor-related protein 6-like
, low density lipoprotein receptor-related protein 6; low density lipoprotein-related protein 6
, low density lipoprotein-related protein 6