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Human LRP6 ELISA Kit for Sandwich ELISA - ABIN418804
Goetzl, Boxer, Schwartz, Abner, Petersen, Miller, Carlson, Mustapic, Kapogiannis: Low neural exosomal levels of cellular survival factors in Alzheimer's disease. in Annals of clinical and translational neurology 2015
Lrp6 asymmetry is controlled by Wnt (show WNT2 ELISA Kits)/PCP (show PRCP ELISA Kits) signaling, indicating that this pathway regulates not only planar- but also apicobasal cell polarity.
PTK7 (show PTK7 ELISA Kits) and LRP6 proteins physically interact, suggesting that PTK7 (show PTK7 ELISA Kits) stabilization of LRP6 protein reciprocally regulates both canonical and noncanonical Wnt (show WNT2 ELISA Kits) activities in the embryo.
Results suggest that Rap2 (show RAP2A ELISA Kits) acts via TNIK (show TNIK ELISA Kits) to regulate the stability of LRP6 receptor for Wnt (show WNT2 ELISA Kits) signaling.
The extracellular domains of Lrp5 (show LRP5 ELISA Kits)/6 behave as physiologically relevant inhibitors of noncanonical Wnt (show WNT2 ELISA Kits) signaling during Xenopus and mouse development in vivo.
Lrp6 plays a critical role in the switch from Wnt (show WNT2 ELISA Kits)/PCP (show PRCP ELISA Kits) to Wnt (show WNT2 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits) signaling.
Kremen2 (show KREMEN2 ELISA Kits) knockdown specifically reduces LRP6 protein levels in neural crest explants.
Waif1a binds to the Wnt (show WNT2 ELISA Kits) coreceptor LRP6 (show LRP5 ELISA Kits) and inhibits Wnt (show WNT2 ELISA Kits)-induced LRP6 (show LRP5 ELISA Kits) internalization into endocytic vesicles, a process that is required for pathway activation.
Results identify GRK5 (show GRK5 ELISA Kits)/6 as novel kinases for the single transmembrane receptor LRP6 (show LRP5 ELISA Kits) during Wnt (show WNT2 ELISA Kits) signaling.
findings revealed an unrecognized role of Caprin-2 (show CAPRIN2 ELISA Kits) in facilitating LRP5 (show LRP5 ELISA Kits)/6 constitutive phosphorylation at G2/M through forming a quaternary complex with CDK14 (show CDK14 ELISA Kits), Cyclin Y (show CCNY ELISA Kits), and LRP5 (show LRP5 ELISA Kits)/6.
results suggest that miR (show MLXIP ELISA Kits)-29b inhibits expression of LRP6 and HuR (show ELAVL1 ELISA Kits) post-transcriptionally, thus playing a role in the regulation of IEC proliferation and intestinal epithelial homoeostasis.
Mutant LRP6 Impairs Endothelial Cell Functions Associated with Familial Normolipidemic Coronary Artery Disease.
LncRNA PTCSC3 inhibits the proliferation and migration of glioma cells and suppresses Wnt (show WNT2 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits) signaling pathway by targeting LRP6
Accordingly, we propose that the anti-fibrotic activity of adiponectin (show ADIPOQ ELISA Kits) may be mediated through AdipoR1 (show ADIPOR1 ELISA Kits)/R2 receptors
findings suggest that rescuing LRP5 (show LRP5 ELISA Kits)/6-mediated Wnt (show WNT2 ELISA Kits) signaling improves neuronal cell survival and reduces tau phosphorylation, which support the hypothesis that Wnt (show WNT2 ELISA Kits) signaling might be an attractive therapeutic strategy for managing AD
Results suggest that miR (show MLXIP ELISA Kits)-126 functions as a tumor-suppressive miRNA by targeting LRP6 regulating Wnt (show WNT2 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits) signaling pathway in papillary thyroid carcinoma.
miR513c functions as a tumor suppressor miRNA, mediated predominantly through the direct suppression of the expression of LRP6.
The interaction between Wnt (show WNT2 ELISA Kits) isoforms and their LRP6 cognate receptor depends on the jutting loop present in Wnt3a (show WNT3A ELISA Kits) but absent in Wnt5b (show WNT5B ELISA Kits).
LRP6 and VEGF levels in the vitreous body from patients with proliferative diabetic retinopathy were increased and correlated mutually.
we identified Lrp6, the gene encoding the coreceptor to Frizzled in the Wnt (show WNT2 ELISA Kits) pathway, as a potential negative regulator of precursor proliferation. Overexpression and siRNA silencing confirmed the regulatory role of Lrp6
These results revealed a new role of the canonical Lrp5 (show LRP5 ELISA Kits)/6-beta-catenin (show CTNNB1 ELISA Kits) pathway in regulating the morphogenesis of the cerebellum during postnatal development.
Data (including data from studies in knockout/transgenic mice) suggest Lrp6 is required for suppression of Sost (sclerostin (show SOST ELISA Kits)) expression by parathyroid hormone (show PTH ELISA Kits) (here, human PTH (show PTH ELISA Kits) peptide 1-34); LRP6 regulates osteocytes expression of histone deacetylases.
Lrp5 (show LRP5 ELISA Kits) binds to Frizzled, preventing Frz-regulated non-canonical Wnt (show WNT2 ELISA Kits) pathway activation and further non-canonical pathway-mediated tumour metastasis.
Wt1 (show WT1 ELISA Kits) expression levels in podocytes regulate Wnt (show WNT2 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits) signaling through modulating the endocytic fate of LRP6, and this indicates a potential target for the therapy of CKD.
N-cadherin (show CDH2 ELISA Kits) modulates Lrp6/PTHR1 (show PTH1R ELISA Kits) interaction, restraining the intensity of parathyroid hormone (show PTH ELISA Kits)-induced beta-catenin (show CTNNB1 ELISA Kits) signaling
LRP6 restrains vascular smooth muscle lineage noncanonical signals that promote osteochondrogenic differentiation, mediated in part via USF1 (show USF1 ELISA Kits)- and arginine methylation-dependent relays.
Urotensin II (show UTS2 ELISA Kits) inhibited the proliferation of cardiac side population cells by JNK (show MAPK8 ELISA Kits)/LRP6 signalling during pressure overload.
Hgf (show HGF ELISA Kits) as an important transactivator of canonical Wnt (show WNT2 ELISA Kits) signaling that is mediated by Met-stimulated, Gsk3-dependent Lrp5 (show LRP5 ELISA Kits)/6 phosphorylation
miR (show MLXIP ELISA Kits)-183, though negatively regulated by Gata3 (show GATA3 ELISA Kits), enhances 3T3-L1 preadipocyte differentiation and adipogenesis by targeting LRP6.
This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.
low density lipoprotein receptor-related protein 6
, lipoprotein receptor-related protein 6
, low-density lipoprotein receptor-related protein 6
, low-density lipoprotein receptor-related protein 6-like
, low density lipoprotein receptor-related protein 6; low density lipoprotein-related protein 6
, low density lipoprotein-related protein 6