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Gnb isoforms control a signaling pathway comprising Rac1, Plcbeta2, and Plcbeta3 leading to LFA-1 (show ITGAL ELISA Kits) activation and neutrophil arrest in vivo
Neuropeptide Y (show NPY ELISA Kits) decreased PLCB2 expression in HUVECs.
high expression of CD133 in triple-negative breast cancer (TNBC)-derived cells correlates with high invasive potential; aggressive properties of CD133high cells are mitigated by PLC-beta2 which down-modulates expression of CD133 and may play a role in preventing metastatic progression of CD133 positive TNBC
WDR26 (show WDR26 ELISA Kits) functions as a scaffolding protein to promote PLCbeta2 membrane translocation and interaction with Gbetagamma, thereby enhancing PLCbeta2 activation in leukocytes.
In this study, we show that staphylococcal enterotoxin B activates a Galphaq (show GNAQ ELISA Kits) and PLCbeta2-dependent pathway in human T cells
gamma-synuclein (show SNCG ELISA Kits) has a role in promoting a more robust G protein Galphaq (show GNAQ ELISA Kits) activation of PLCbeta2
GPCR (show NMUR1 ELISA Kits) activation of Ras and PI3Kc in neutrophils depends on PLCb2/b3 and the RasGEF RasGRP4 (show RASGRP4 ELISA Kits).
WDR36 acts as a scaffold protein (show HOMER1 ELISA Kits) tethering a G-protein-coupled receptor (show ADRA1A ELISA Kits), Galphaq (show GNAQ ELISA Kits) and phospholipase C beta 2 in a signalling complex
Rac1 activates phospholipase Cdelta1 through phospholipase Cbeta2
Data show that activation of PLCbeta(2) by alpha(q) and beta1gamma2 differ from activation by Rac2 (show RAC2 ELISA Kits) and from each other.
Galphaq (show GNAQ ELISA Kits)-coupled Lpar1 (show LPAR1 ELISA Kits) regulates cell proliferation and migration by activating two distinct PLC (show HSPG2 ELISA Kits)-beta isozymes, PLC (show HSPG2 ELISA Kits)-beta1 and PLC (show HSPG2 ELISA Kits)-beta2, respectively.
GPCR (show GPBAR1 ELISA Kits) activation of Ras and PI3Kc in neutrophils depends on PLCb2/b3 and the RasGEF RasGRP4 (show RASGRP4 ELISA Kits).
A PLCbeta/PI3Kgamma (show PIK3CG ELISA Kits)-GSK3 signaling pathway regulates cofilin (show CFL1 ELISA Kits) phosphatase slingshot2 and neutrophil polarization and chemotaxis.
The beta2 isoform mediates close to one-half the chemokine-induced calcium signal in resting and anti-IgM-activated B cells.
Taurine supplementation increases insulin (show INS ELISA Kits) secretion, favouring both influx and internal mobilisation of Ca2 (show CA2 ELISA Kits)+; these effects seem to involve multiple pathways.
Expression of Plcb2 was studied in a cell line during myoblast differentiation.
both PLCbeta2/beta3 and PI3Kgamma (show PIK3CG ELISA Kits) play vital roles in platelet cytoskeletal dynamics
loss of PLCbeta2 and PLCbeta3 significantly impaired T cell migration.
Transgenic PLCb2-GFP mice label taste bud cells and olfactory microvillar cells. Immune cells not examined.
may play a role in inositol mediated signal transduction of bitter taste perception
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
, 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-2
, PKC beta II
, phosphoinositide phospholipase C-beta-2
, phospholipase C-beta-2