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Gnb isoforms control a signaling pathway comprising Rac1, Plcbeta2, and Plcbeta3 leading to LFA-1 (show ITGAL Proteins) activation and neutrophil arrest in vivo
Neuropeptide Y (show NPY Proteins) decreased PLCB2 expression in HUVECs.
high expression of CD133 in triple-negative breast cancer (TNBC)-derived cells correlates with high invasive potential; aggressive properties of CD133high cells are mitigated by PLC-beta2 which down-modulates expression of CD133 and may play a role in preventing metastatic progression of CD133 positive TNBC
WDR26 (show WDR26 Proteins) functions as a scaffolding protein to promote PLCbeta2 membrane translocation and interaction with Gbetagamma, thereby enhancing PLCbeta2 activation in leukocytes.
In this study, we show that staphylococcal enterotoxin B activates a Galphaq (show GNAQ Proteins) and PLCbeta2-dependent pathway in human T cells
gamma-synuclein (show SNCG Proteins) has a role in promoting a more robust G protein Galphaq (show GNAQ Proteins) activation of PLCbeta2
GPCR (show NMUR1 Proteins) activation of Ras and PI3Kc in neutrophils depends on PLCb2/b3 and the RasGEF RasGRP4 (show RASGRP4 Proteins).
WDR36 (show WDR36 Proteins) acts as a scaffold protein (show HOMER1 Proteins) tethering a G-protein-coupled receptor (show ADRA1A Proteins), Galphaq (show GNAQ Proteins) and phospholipase C beta 2 in a signalling complex
Rac1 activates phospholipase Cdelta1 through phospholipase Cbeta2
Data show that activation of PLCbeta(2) by alpha(q) and beta1gamma2 differ from activation by Rac2 (show RAC2 Proteins) and from each other.
Galphaq (show GNAQ Proteins)-coupled Lpar1 (show LPAR1 Proteins) regulates cell proliferation and migration by activating two distinct PLC (show HSPG2 Proteins)-beta isozymes, PLC (show HSPG2 Proteins)-beta1 and PLC (show HSPG2 Proteins)-beta2, respectively.
GPCR (show GPBAR1 Proteins) activation of Ras and PI3Kc in neutrophils depends on PLCb2/b3 and the RasGEF RasGRP4 (show RASGRP4 Proteins).
A PLCbeta/PI3Kgamma (show PIK3CG Proteins)-GSK3 signaling pathway regulates cofilin (show CFL1 Proteins) phosphatase slingshot2 and neutrophil polarization and chemotaxis.
The beta2 isoform mediates close to one-half the chemokine-induced calcium signal in resting and anti-IgM-activated B cells.
Taurine supplementation increases insulin (show INS Proteins) secretion, favouring both influx and internal mobilisation of Ca2 (show CA2 Proteins)+; these effects seem to involve multiple pathways.
Expression of Plcb2 was studied in a cell line during myoblast differentiation.
both PLCbeta2/beta3 and PI3Kgamma (show PIK3CG Proteins) play vital roles in platelet cytoskeletal dynamics
loss of PLCbeta2 and PLCbeta3 significantly impaired T cell migration.
Transgenic PLCb2-GFP mice label taste bud cells and olfactory microvillar cells. Immune cells not examined.
may play a role in inositol mediated signal transduction of bitter taste perception
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
, 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-2
, PKC beta II
, phosphoinositide phospholipase C-beta-2
, phospholipase C-beta-2