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anti-Human Phospholipase C beta 4 Antibodies:
anti-Mouse (Murine) Phospholipase C beta 4 Antibodies:
anti-Rat (Rattus) Phospholipase C beta 4 Antibodies:
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Fly (Calliphora) Monoclonal Phospholipase C beta 4 Primary Antibody for BI, IF - ABIN968583
Alvarez, Ghalayini, Xu, Hardcastle, Bhattacharya, Rao, Pettenati, Anderson, Baehr: cDNA sequence and gene locus of the human retinal phosphoinositide-specific phospholipase-C beta 4 (PLCB4). in Genomics 1996
Show all 4 Pubmed References
Fly (Calliphora) Monoclonal Phospholipase C beta 4 Primary Antibody for IF, WB - ABIN968900
Kano, Hashimoto, Watanabe, Kurihara, Offermanns, Jiang, Wu, Jun, Shin, Inoue, Simon, Wu: Phospholipase cbeta4 is specifically involved in climbing fiber synapse elimination in the developing cerebellum. in Proceedings of the National Academy of Sciences of the United States of America 1999
Show all 4 Pubmed References
Dysregulation of primary PLC (show HSPG2 Antibodies) signaling is linked to several brain disorders including epilepsy, schizophrenia, bipolar disorder, Huntington's disease, depression and Alzheimer's disease. (Review)
Novel pathogenic variants in PLCB4 have been found in two of three index patients with typical Auriculocondylar syndrome.
Our observations of this case further delineate the phenotype of ACS (show PLA2G15 Antibodies) associated with autosomal recessive PLCB4 loss-of-function mutations, underscoring gastrointestinal dysfunction and severe sleep-related breathing abnormalities as additional features when compared to patients with heterozygous mutations with a presumed dominant negative effect.
PLCB4 copy gain and PLCB4 overexpression is associated with gastrointestinal stromal tumors.
recurrent mutation in PLCB4 is associated with uveal melanoma.
Polymorphism of the PLCB4/B1 genes might be involved in the coronary artery aneurysm pathogenesis of Kawasaki disease.
This study demonistrated by Gene expression profile that PLCB4 upregulaion in fibroblasts of Huntington's disease patients.
Auriculocondylar syndrome is caused by PLCB4 mutations inherited not only in an autosomal dominant manner (catalytic domain missense mutations) but also inherited as autosomal recessive (complete loss of function).
The phenotypic variability of auriculocondylar syndrome suggests that mutations in this pathway, especially those affecting core signaling molecules such as PLCB4 and GNAI3 (show GNAI3 Antibodies), should be considered as potential candidates for other ear and jaw malformations.
The significant contribution of PSMD3 (show PSMD3 Antibodies)-CSF3 (show CSF3 Antibodies) and PLCB4 loci to the regulation of neutrophil count, is demonstrated.
The results of our study showed that thalamic mGluR1 (show GRM1 Antibodies)-PLCbeta4 pathway was critical in controlling sleep architecture.
Tnis study demonistrated that plc (show HSPG2 Antibodies) beta4 distribuate in mice cerebellum
Presence of PLCbeta(4) in the heart and in HL-1 (show ASGR1 Antibodies) cardiomyocytes showing a different species-dependent pattern of expression of the PLCbeta((1-4)) transcripts.
impaired LGNd relay, possibly mediated via group-1 mGluR (show GRM8 Antibodies), may underlie irregular sleep sequences and ultradian body temperature rhythms in PLC (show HSPG2 Antibodies)-beta4-/- mice
These findings suggest that (1) PLC-beta 4 in the medial septum is involved in controlling cholinergic theta oscillation and (2) cholinergic theta rhythm plays a critical role in suppressing anxiety.
PLCB4 has a role in synapse elimination and plasticity in developing and mature cerebellum.
These findings indicate that the thalamic mGluR1 (show GRM1 Antibodies)-PLCbeta4 cascade is indispensable for the formalin-induced inflammatory pain by regulating the response of VPL neurons
Expression of Plcb4 was studied in a cell line during myoblast differentiation.
excitatory synaptic inputs to Purinje cells activate the Ca2 (show CA2 Antibodies)+-assisted mGluR1 (show GRM1 Antibodies)-PLCbeta4 cascade, and produce 2-arachidonoylglycerol, which retrogradely modulates synaptic transmission
We report here a normal distribution of midbrain dopaminergic cell bodies and axonal projection to the striatum in phospholipase C beta 4-/- mice.
The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals in the retina. Multiple transcript variants encoding different isoforms have been found for this gene.
phospholipase C beta 4
, 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4
, dJ1119D9.2 (Phopholipase C, beta 4 (1-Phosphatidylinositol-4,5-Bisphosphate Phosphodiesterase Beta 4))
, monophosphatidylinositol phosphodiesterase
, phosphoinositidase C
, phosphoinositide phospholipase C-beta-4
, triphosphoinositide phosphodiesterase
, 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-4
, phosphoinositide phospholipase C
, phospholipase C-beta-4
, phospholipase C beta