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In mo (show PLCD1 ELISA Kits)use, Plcd1 and Plcd3 may act together in murine hair follicles.
Data are consistent with the idea that phospholipase C (show PLC ELISA Kits) d1 and d3 isoforms support the growth and migration of normal and neoplastic mammary epithelial cells in vitro.
Plcd1 (show PLCD1 ELISA Kits) and Plcd3 have synergistic effects on the murine hair follicle in specific regions of the body surface.
These results indicate that PLCdelta3 could participate in stability of microvilli structure via regulating and anchoring of Myo6 (show MYO6 ELISA Kits) to plasma membrane.
PLCdelta3 negatively regulates RhoA (show RHOA ELISA Kits) expression, inhibits RhoA (show RHOA ELISA Kits)/Rho kinase (show ROCK2 ELISA Kits) signaling, and thereby promotes neurite extension.
double disruption of PLCd1 (show PLCD1 ELISA Kits) and PLCd3 results in embryonic lethality because of insufficient vasculariztion of the placenta.
This gene encodes a member of the phospholipase C family, which catalyze the hydrolysis of phosphatidylinositol 4,5-bisphosphate to generate the second messengers diacylglycerol and inositol 1,4,5-trisphosphate (IP3). Diacylglycerol and IP3 mediate a variety of cellular responses to extracellular stimuli by inducing protein kinase C and increasing cytosolic Ca(2+) concentrations. This enzyme localizes to the plasma membrane and requires calcium for activation. Its activity is inhibited by spermine, sphingosine, and several phospholipids.
phospholipase C delta 3
, phospholipase C, delta 3
, 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3
, 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-3
, PLC delta3
, phosphoinositide phospholipase C-delta-3
, phospholipase C-delta-3